Research Associate at The Centre for Developmental

2 weeks ago

London, United Kingdom King's College London Full time

Job id: 087206. Salary: £43,205 - £50,585 per annum, including London Weighting Allowance.

Posted: 03 April 2024. Closing date: 28 April 2024.

Business unit: IoPPN. Department: Developmental Neurobiology.

Location: Guy's Campus. Category: Research.

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Job description

Applications are invited for 2 postdoctoral researcher positions funded by the Wellcome Trust.

The successful applicant will pursue a research project as an integral member of a group working on neural circuits underlying flexible cognitive behaviour in mice. The project will aim to understanding how brain-wide neural circuits lead to flexible cognitive behaviours. The techniques employed may include chronic in-vivo 2-photon and 3-photon calcium imaging of excitatory and inhibitory cell classes, targeted holographic optogenetic manipulations, extracellular neuropixel recordings, viral vector based functional circuit mapping, and quantitative mouse behaviour.

The successful applicant will benefit from the collaborative culture of the Centre for Developmental Neurobiology at King’s College London and will have the opportunity to develop collaborations with groups studying animal models of brain disorders.

The selection process will be a panel interview.

Both posts will be offered on full-time, fixed term contracts for 2 years.

Key responsibilities

Undertake original research as part of a team working on the neural circuit basis of cognition.

Perform mouse behavioural training on a task-switching paradigm

Perform neural recordings during mouse task-switching behaviour using 2-photon/3-photon imaging or extracellular neuropixel recordings

Perform widefield calcium imaging

Perform optogenetics during mouse task-switching behaviour

Maintain up-to-date, accurate and comprehensive lab notes and to undertake the analysis of results of research studies as stated above.
- The above list of responsibilities may not be exhaustive, and the post holder will be required to undertake such tasks and responsibilities as may reasonably be expected within the scope and grading of the post._

Skills, knowledge, and experience

Essential criteria

1. PhD complete or thesis submitted in neuroscience or related discipline

2. Strong research contribution to questions of neural circuits and behaviour, or other questions relevant to the lab interests

3. Ability to perform analysis of complex datasets

4. Ability to trouble-shoot laboratory problems

Desirable criteria

1. Experience with in-vivo imaging or electrophysiology, ideally during animal behaviour

2. Experience with in-vivo optogenetics, ideally during animal behaviour

3. Experience in computational approaches to explore neural circuits and behaviour

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