23p-53 Bioinformatician/senior Bioinformatician

**Organisation position and purpose**

We are looking for a bioinformatician to join the core Bioinformatics facility of the Pirbright Institute. This post is a permanent position incorporating a service component as well as opportunities for research. The Institute has excellent livestock containment facilities and well-tuned core facilities (sequencing, microscopy and flow cytometry) producing unique datasets.

This post will report to the head of Computational Biology. There are three components to the position: 50% sequencing-based core bioinformatics, 25% research with Genomics and Computational Biology groups and up to 25% bought research time for projects requiring bespoke support.

**This post is offered at Band D/E, depending on experience.**

**Main duties and responsibility**

**Core Facility Tasks**:
**Band D**
- Data manipulation and visualisation for diverse data modalities (especially sequencing)
- Develop and maintain RNA-Seq and differential expression pipeline(s)
- Design and implement a spatial transcriptomics, single cell RNA-Seq pipeline
- Aid the development of bioinformatics pipelines for the analysis of omics datasets
- Communicate progress and results within the team and to collaborators
- Assist in the day-to-day running of a compute cluster

**Band E**
- Data manipulation and visualisation for diverse data modalities (especially sequencing)
- Develop and maintain RNA-Seq and differential expression pipeline(s)
- Design and implement a spatial transcriptomics, single cell RNA-Seq pipeline
- Lead the development of bioinformatics pipelines for the analysis of omics datasets
- Communicate progress and results within the team and to collaborators
- Lead in the day-to-day running of a compute cluster

**Research with Genomics and Computational Biology Groups on specific projects**:
**Band D/E**
- Freedom to interact with wet-lab scientists producing unique datasets
- Work closely with two new analytics groups: Genomics and Computational Biology
- Help to expand and exploit a versatile set of sequencing capabilities located in high containment, in close collaboration with the Sequencing core facility

This job description is only an outline of the tasks, responsibilities and outcomes required of the role. The jobholder will carry out any other duties as may be reasonably required by his/her line manager. The job description and personal specification may be reviewed on an ongoing basis in accordance with the changing needs of The Pirbright Institute.

All employees shall actively participate in the Institute-wide quality assurance system in conjunction with the Institute’s Quality Manager. _Employees are also expected to safeguard their own health and safety and security by following policies and all e_mployees are responsible for the Health and Safety and security of staff under their management.

**Personal specification**
- Results driven with a clear ability to drive and organise multiple projects.
- Good collaboration skills.
- Attention to detail.
- Able to problem solve and be creative in generating a solution whilst also able to perform the same activity in a consistent manner.
- Ability to work independently as well as part of a team in an interdisciplinary environment
- Critical mind.

**Specific requirements**

**Essential**

Band D
- A PhD or equivalent in bioinformatics, computer science or relevant discipline
- Experience with high-throughput sequencing data analysis
- Knowledge of Unix and Linux operating systems
- Proficiency in R and/or Python programming and versioning tools

Band E
- A PhD or equivalent in bioinformatics, computer science or relevant discipline
- Significant and relevant experience in a bioinformatics R&D environment
- Experience with high-throughput sequencing data analysis
- Knowledge of Unix and Linux operating systems
- Proficiency in R and/or Python programming and versioning tools
- Strong experience in building and deploying distributed pipelines for data science

**Desirable**

Band D
- Experience in working with diverse biological data types (ideally in livestock or immunity)
- Some understanding of AI and machine learning within computational biology contexts
- Excellent oral and written communication skills
- Experience in 10X chromium-generated data analysis
- Ability to work within, but not restricted by, an MS Windows work environment
- A publication records commensurate to the applicant’s career stage

Band E
- Experience in working with diverse biological data types (ideally in livestock or immunity)
- Clear understanding of AI and machine learning within computational biology contexts
- Excellent oral and written communication skills
- Previous involvement in setting up and/or maintaining computing clusters
- Experience in 10X chromium-generated data analysis
- Ability to work within, but not restricted by, an MS Windows work environment
- A publication records commensurate to the applicant’s career stage

**This post is offered