Phd C. Elegans Researcher

1 month ago

StocktononTees, United Kingdom Magnitude Biosciences Ltd Full time

_**NERVSPAN**_ **project**

Decline of neuronal function with age is a serious issue in human ageing and age-related diseases such as Parkinson’s and Alzheimer’s disease. The nematode worm _C. elegans_ is a powerful whole organism model for fundamental neuronal function. It possesses the main neurotransmitters found in humans, and it has been shown that these neurotransmitters affect specific behaviours of the worm that can be measured.

Magnitude Biosciences Ltd is a specialised Contract Research Organisation that support drug discovery and product development for a range of clients across the world. We use _C. elegans_ to together with our innovative automated WormGazer technology to answer the research questions of our clients, particularly in field of health, ageing and disease. Our vision is to support the development of therapies that could prevent or treat age-released disease whilst establishing the use of _C. elegans_ as an accepted in vivo model in industrial drug discovery.

This project aims to understand how these neuronal functions change with age, and how specific neurotransmitters are involved by designing and validating custom-made behavioural assays using our automated WormGazer technology.

**Objectives**

In this project you will:

- To identify existing manual assays of neuronal function that will benefit from automation and will be of use to clients
- To prototype automated assays using the WormGazer to understand if the assay is a reliable readout of neuronal function, and is influenced by known neurotransmitters and related genetic pathways
- To validate assays with drugs known to influence neuronal function
- To work with the wider network to automate assays of use for drug discovery

Development of these automated assays will allow new discoveries in cellular neurobiology and provide a useful platform for developers of new therapies.

Our small but quickly growing lab is based in NETPark Sedgefield in the North East of England. A short distance from Newcastle upon Tyne and the historic city of Durham.

In return, we offer a competitive salary, including living allowances and mobility allowances, as well as the opportunity to work in a supportive, multidisciplinary and dynamic research environment. This is an excellent opportunity for a talented and ambitious individual to develop their research skills, gain international experience, and enhance their career prospects.

We look forward to hearing from you

**Job Types**: Full-time, Fixed term contract, Graduate
Contract length: 36 months

**Salary**: From £30,000.00 per year

**Benefits**:

- Company pension

Schedule:

- 8 hour shift
- Monday to Friday

Supplemental pay types:

- Bonus scheme

Ability to commute/relocate:

- Stockton-on-Tees: reliably commute or plan to relocate before starting work (required)

Application question(s):

- Have lived in the UK for less than 12 months within the last 3 years?

**Education**:

- Master's (required)

Work Location: In person

Application deadline: 14/07/2023
Reference ID: NERVSPAN MBUK

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