Research Assistant

3 weeks ago

Newcastle upon Tyne, United Kingdom Newcastle University Full time

**Salary**:
**Research Assistant**: £31,396 to £32,332 per annum
**Research Associate**: £33,966 to £44,263 per annum

Newcastle University is a great place to work, with excellent benefits. We have a generous holiday package; plus the opportunity to buy more, great pension schemes and a number of health and wellbeing initiatives to support you.

**Closing Date**: 09 June 2024

The Role

As part of our commitment to career development for research colleagues, the University has developed 3 levels of research role profiles. These profiles set out firstly the generic competences and responsibilities expected of role holders at each level and secondly the general qualifications and experiences needed for entry at a particular level.

This position involves the design, execution, and analysis of experimental systems for DNA-based data storage in vitro or/ and in vivo. You will work in a cutting-edge field, combining principles of molecular biology, synthetic biology and computing science to pioneer new methods of data storage and retrieval using DNA as a data storage medium.

The role will require regular liaison with the other investigators in the project (specifically) and the research group (more generally) to aid in designing and carrying out experiments in in vitro or/and in vivo information storage. More specifically, the post holder will work collaboratively with our other nanobiotechnologists and scientific computing experts to achieve project goals. The post holder will also provide assistance to, and training of, academic, technical and research staff and students on specific experimental techniques and in the use of specialised experimental equipment when necessary. To keep excellent records of all laboratory experiments, procedures, protocols, workflows and outcomes, enabling reuse, interpretation with team members and delivery of project milestones.

The appointment is fixed-term, tenable for 30 months in the first instance. The position is available on a full-time basis (37 hours per week).

Are you ready to make a remarkable impact in the world of Computing Science? Join us at the forefront of innovation and discovery at the School of Computing, Newcastle University. As a beacon of excellence in technological advancement, we foster a dynamic and collaborative environment where creativity thrives, and boundaries are pushed. Our School boasts a rich heritage of ground-breaking research and a commitment to nurturing the brightest minds in the field. With state-of-the-art facilities and a diverse community of experts, we are passionate about empowering our students to explore, innovate, and redefine the possibilities of computing. Come be part of our pioneering journey, where your expertise and vision will shape the future of technology.

Key Accountabilities
Design and develop experimental systems for DNA data storage and retrieval
Conduct experiments to test the viability, efficiency, and accuracy of DNA- based data storage systems in vitro and in vivo developing repeatable experimental protocols in vitro (e.g. cell free extracts) as well as in both prokaryotes (E.coli and B.subtilis) and eukaryotes (initially S.cerevisiae)
Analyse experimental data and contribute to the fine tuning of computational models and simulations
Collaborate with interdisciplinary teams to integrate biological systems with computing technologies as well as considering responsible research and innovation matters
Document and report experimental procedures and findings in scientific journals and to project stakeholders
Contribute to the design of scalable, high-throughput workflows to speed-up laboratory operations for points 1 & 2
Oral presentations at meetings, workshops and conferences
Contribute to the social media content for the project

The Person

Knowledge, Skills and Experience

Essential for research assistant and research associate Demonstrable molecular biology, biochemistry and/or microbiology experience. Demonstrable laboratory experience in synthetic biology, microbiology, or molecular biological techniques, e.g., DNA sequencing and synthesis, plasmids and chromosomal manipulation techniques, operons design and assembly, DNA replication, stability, cloning and transformation in Bacillus spp., E. coli or S.cerevisiae. Publication of work in relevant peer-reviewed conferences and journals. Presentation of scientific work at group meetings and scientific events.

Essential for research associate Demonstrable experience in DNA data storage or other relevant fields in synthetic biology or DNA nanotechnology, e.g., experimental realisation of DNA computing systems utilising strand displacements, DNA/RNA origami, etc. Ability to supervise student projects and support with teaching and demonstrating activities.

Desirable for research assistant and research associate Demonstrable experience with advanced molecular techniques such as utilisation of reverse transcriptase, flipases, CRISPR/CAS system, CRISPR prime,

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