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Research Assistant/research Associate in Biosecurity
4 months ago
**Salary**:
**Research Assistant**: £31,396 to £32,982 per annum
**Research Associate**: £33,966 to £44,263 per annum
Newcastle University is a great place to work, with excellent benefits. We have a generous holiday package; plus the opportunity to buy more, great pension schemes and a number of health and wellbeing initiatives to support you.
**Closing Date**: 16 June 2024
The role
The Environmental Biotechnology Innovation Centre (EBIC), which ICOS is a member, brings together scientists from ten leading UK institutions in a mission to engineer the properties and functions of micro-organisms, creating more effective ways to monitor the environment and remove pollutants. The Cyanobacteria Engineering for Restoring Environments (CYBER) project aims to develop the foundational multidisciplinary tools needed to de-risk environmentally focused engineering biology and ultimately support its future deployment into real-world ecosystems.
Your role will be to analyse microbial genomes (or metagenomes). You will identify and annotate coding regions, ORFs, regulatory regions and intergenic sections using available information to develop new algorithms and databases when needed. You will have the opportunity to use your skills to improve the traceability of engineered cells and plasmids and their biosecurity.
You will have regular liaison with the other investigators in the projects and the research group, as well as international collaborators. It is important that you keep excellent records of all the activities to deliver the project milestones and retain valuable information to be able to reuse and communicate withing the team.
This role is fixed term for a period of 24 months.
Interviews will be held on 5th July 2024.
Key Accountabilities
- Improve the traceability of engineered cells in natural environments by designing and synthetizing robust genomic barcodes & watermarks and use sequencing technology to track cells in complex environments and ensure their long-term trustworthiness
- Design, specify and implement bioinformatics software, pipelines and workflows to underpin our projects biosecurity including the automated identification of neutral sites for barcode/watermark insertion
- Automate the determination, annotation and analysis of microbial strain sequences (e.g. 16s rRNA gene sequencing, whole genome sequencing, metagenome sequencing, transcriptome sequencing, plasmids sequencing, etc) and integrate into bioinformatics workflows
- Integrate genome, metagenome and plasmid sequences comparison into workflows (e.g. with OGRIs, ANI, dDDH, etc)
In addition, for Research Associate
- Design genetically engineered biocontainment strategies for engineered microbial species
- Develop AI technologies for enhancing biosecurity and/or biocontainment aspects of DNA sequencing and synthesis as well as engineered cells and plasmids traceability
- Integrate the above into the CellRepo platform technology stack to maintain ICOS and its various projects cell lines & plasmids catalogue
- Contribute to grant writing
- Support our group's social scientist with regards to Responsible Research and Innovation. Contributing also to the public communication of ICOS activities
The Person
Knowledge, Skills and Experience
- Knowledge of plant microbial bioinformatics
- Understanding of microbial genetics
- Experience of integrating diverse sources of information and data to achieve accurate results
- Experience in genomics and transcriptomics technologies and bioinformatics
- Demonstrable expertise in programming including Ruby, Python, Java(script) or C/ C++.
- Competence in Linux or OS X programming environments
- Understanding of software engineering good practices (e.g. version control, testing, documentation, debugging, etc)
In addition, essential for Research Associate
- Publication of work in relevant peer-reviewed conferences and/or journals
- Presentation of work at scientific meetings
- Experience in the utilisation and development of social media for public dissemination and outreach
Desirable
- Molecular biology, Synthetic Biology or Biotechnology laboratory experience
- AI experience
Attributes and Behaviour
- An independent, resourceful, reliable, team player
- An ability to communicate effectively via oral and written media (e.g. technical reports, papers, presentations)
- Capacity for original thought
- Ability to interact with people from different disciplines
- Punctual and dependable, showing commitment to the role and wider school
- Ability to deliver results to tight deadlines
**Qualifications**:
- An undergraduate and masters degree in computer science, engineering, mathematics, bioinformatics or closely related fields (Research Assistant)
- A PhD degree in bioinformatics, biosecurity, synthetic biology or very closely related field (Research Associate)
Newcastle University is a global University where everyone is treated with dignity and respect. As a University of Sanctuary, we aim t
