Computational Postdoctoral Fellow

1 month ago

Hinxton, United Kingdom Wellcome Sanger Institute Full time

Do you want to help us improve human health and understand life on Earth? Make your mark by shaping the future to enable or deliver life-changing science to solve some of humanity’s greatest challenges.

About the Role:
We are looking for a Computational Postdoctoral Fellow to help deliver Project Symphony, an OpenTargets-funded Project aiming to perform extensive combinatorial CRISPR screening of cancer cell lines at the Wellcome Sanger Institute. This position will be for a 3-year fixed term contract. You will join the

Experimental Cancer Genetics Team

lead by

David Adams


About Us:
_KRAS_-mutant colorectal cancer (CRC) and triple negative breast cancer (TNBC).

In this project, we will focus on lung cancer, which is the malignancy associated with the largest number of deaths world-wide and is increasing in frequency in some groups such as women. The genetics of lung cancer is well studied, with activating mutations in oncogenes such as
_KRAS_ and
_EGFR_,
_ _and loss-of function events in genes such as
_p53,_
- NF1_ and
_STK11_,
_ _characterizing the somatic genetic landscape. In this project, we aim to leverage the unique CRISPR screening platform of the Wellcome Sanger Institute, the expertise in CRISPR screen and single cell analyses of EMBL, and the drug development and cancer model expertise of our Pharma partners to identify and characterize new therapeutic target combinations for lung cancer. Effective targeting of synthetic lethal interactions, including those that are cancer cell specific owing to the presence of somatic alterations in the tumour, may be exquisitely precise - as evidenced by the use of PARP inhibitors in
_BRCA1/2_ mutant breast cancer, where treatment elicits cancer cell death while leaving normal tissues untouched.

In this project, we will use a combination of both established CRISPR/Cas9 technology and new CRISPR technologies with the aim of identifying genetic interactions and gaining mechanistic insights into the cellular effects of gene co-disruption.

You will be responsible for:
- Proactively driving data analysis working with other members of the team. This will involve deploying existing methods and also developing new approaches to data analysis.- Working closely with other computational biologists to analyse and interpret data and to present these data to the team, pharma partners and scientific community.- Remaining at the forefront of new technologies and methods for CRISPR screening.

As a PDF, you will take ownership of projects and aim to publish and present your work at leading research meetings.

About you:
If you have experience working with large-scale genomic data, CRISPR screening or genomic analysis, and you are seeking a multi-faceted and challenging role, this job might be for you

You are a detail-oriented problem solver motivated by our mission of delivering high-quality data and analysis results to partners. If you are motivated by continuous improvement, and are excited to lead by example by sharing ownership of team processes and ways of working with the team lead and other senior team members, then please get in touch

Joining us as Postdoctoral Fellow:
You will be part of a vibrant international

Postdoctoral Fellow community

at the Sanger Institute with a wide programme of transferable skills training and excellent career development opportunities. We are committed to:

- Providing an enriching and respectful research environment so you can focus on and enjoy your work
- Mentoring you and providing opportunities for you to network across the genomics scientific community

For more information about being a Postdoctoral Fellow - please visit:
Essential Skills:
Technical Skills:
- PhD in computational biology, bioinformatics, biostatistics or related scientific discipline- Understanding and experience in the fields of genomics, data processing and high
- throughput data analysis- Extensive experience in a research environment with an established track record of productivity- Proficiency in one or more scripting languages (R, python)

Competencies and behaviours:
- Excellent communication and organisational skills.- Proven independent working style, technical problem solving, data analysis and generation of novel ideas- Motivation and ambition to make a personal contribution to GRL research- Proven ability to work effectively within a team- Ability to work multi-task and organise own workload- Good attention to detail and record keeping- Demonstrates inclusivity and respect for all

Other information:
Salary per annum: £35,707-£39,193

Application Process:
Closing Date: 19th February 2023

Working at Wellcome Sanger:
Our flexible-hybrid working environment is designed to support a healthy work-life balance. This means you can work flexibly with a combination of working from home, and working from our Campus to allow you to focus on being productive and part of the team while enjoying the benefits of working flexibly.

We aim to at

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