Research Fellow

4 weeks ago


St Andrews, United Kingdom University of St Andrews Full time

Applications are sought for a committed Research Fellow to work with Dr Paolo Annibale, at the School of Physics and Astronomy, conducting research for a Leverhulme Trust funded project entitled _Bottom up nanoscale control of compartmentalized cellular signaling: geometry and finesse._

The primary duties will be to support the team working on fundamental cell biology questions using innovative physical approaches. The focus of the project will be to establish micromechanical and optical platforms to control the local geometry of living cells, in order to observe in a controlled environment the effect of modulating geometry on key signalling cascades used by human cells to respond to extracellular stimuli. Advanced fluorescence microscopy approaches, including super-resolution imaging and novel biosensors will be the experimental cornerstones of our strategy. The successful applicant will be expected to lead the cell biology axis of the project, establishing new cell lines using gene editing technologies and developing new tools for the visualization of intracellular proteins using fluorescence microscopy. The successful applicant will have to interface with a highly interdisciplinary team, and will have the opportunity (and challenge) of becoming familiar with methods outwit the strict remit of the life sciences.

The successful applicant will have (or be near to completion of) a PhD in Biology/Biotechnology/Biomedical Engineering with expertise in cell and molecular biology, specifically in the use of Crispr/Cas9 gene editing as well as hiPSC handling and differentiation. Expertise in fluorescence microscopy, either confocal imaging, single particle tracking or fluorescence correlation spectroscopy will be advantageous. Ability to work successfully in a small team, and willingness to learn new methods will be amongst key characteristics sought in the successful applicant.

The post is available for 24 months starting 1st May 2023 or as soon as possible thereafter, with the possibility of extension upon satisfactory performance, for up to a total of 54 months.

Applications are particularly welcome from women, people from the Black, Asian and Minority Ethnic (BAME) community, and other protected characteristics who are under-represented in research posts at the University.

**Interviews will be held on 15 March 2023**

**Please quote ref: AR2780MR**

**Closing Date: 28 February 2023**

**Further Particulars**:AR2780MR FPs.doc**

School of Physics & Astronomy

**Salary**: £35,333 - £38,592 per annum

Fixed Term: 24 months

Start: 1 May 2023 or as soon as possible thereafter


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