Research Scientist Molecular Biology

4 weeks ago

United Kingdom Baseimmune Full time

Team: R&D, Translational Research Team, Target modelling and vaccine delivery.
Immediate
Period: Full time, permanent
Location: London Bioscience Innovation Centre in King’s Cross, London (On-site)
Baseimmune is a discovery stage biotechnology start-up focused on revolutionising vaccines through advanced computational antigen design. Founded by the team that pioneered computational vaccines at the Jenner Institute University of Oxford, our mission is to harness the fields of data science, machine learning and computational biology within a multi-disciplinary team to redefine cross-protective and mutation-proof vaccines.

We are seeking a highly motivated and skilled molecular virologist to join the growing lab team at Baseimmune and be a core member of the Translational Research Team as part of the Formulation and Delivery optimisation units. This is a lab-based role that requires a combination of scientific and technical expertise in the fields of virology, molecular biology, cell biology and assay development. The role offers the opportunity to work across different teams in an innovative and fast-paced research environment, in a growing biotechnology company, where your contributions will directly impact and shape the development of groundbreaking vaccines.

In this role, you will provide and apply your expertise and knowledge to a) the design, validation, optimisation, and execution, of neutralisation assays to evaluate our innovative candidates , b) assessment and optimisation of novel vaccine delivery platforms including protein based nanoplatform- and -lipid based mRNA formulations and c) assist in the development of novel functional assays to assess performance of our vaccine candidates. You will actively participate in the execution of translational research and vaccine development programmes, contribute to strategy and design of the pipeline, and mentor technical staff. The ideal candidate should have a strong knowledge and technical experience in molecular virology and cell biology and should be confident in a range of applied molecular biology and biochemistry assays, including cell culture, lentivirus/pseudovirus design and production, molecular cloning and (pseudo)neutralisation assays.

This role is ideal for individuals seeking growth and advancement in the vaccine development field, while contributing to the ambitious objectives of a dynamic company like Baseimmune.

Generate fit-for-purpose designed stable cell lines as part of our target validation platforms to assess the design and performance of our vaccine candidates.
To obtain a Home Office Personal Licence (PIL A-C) to work with rodents (supported by the company), gain hands-on experience with animal models and actively participate in the designing and overseeing of in vivo experiments
Collaborating effectively with other functions within the Translational Research team to support and assist their research activities as needed (according to your experience and/or following adequate training and supervision), including supporting the training and mentoring of junior research staff.
Demonstrating and maintaining knowledge in own area of expertise using literature and database data and apply it to critical analysis of new targets and the successful execution of experiments.
Maintain detailed records and analysis of experimental procedures, observations, and results in compliance with data integrity procedures and contribute to the preparation of study reports and presentations in a timely and accurate manner.
Contribute to good laboratory principles, health and safety practices in the lab, including routine cleaning, maintenance, housekeeping responsibilities, as well as writing and reviewing of risk assessments and SOPs as needed.

A PhD in Virology, Molecular Biology, Immunology, Cell Biology, or other related discipline with applicable experience in virology; OR Master's Degree in a relevant subject plus a minimum 4 year of relevant research experience in an academic or biotech/pharma setting.
Strong knowledge of virology, molecular and cellular biology applied to assay development.

Production, characterisation, and QC of viral vectors/LNPs/VLPs for vaccine/gene delivery.
Extensive experience in cell and molecular biology techniques including cloning, plasmid design, DNA amplification in bacteria, transfection, mammalian cell-line maintenance, immunofluorescence assay, etc.
Inclusive, collaborative, and thrives in a team environment with a flexible approach to working.
Able to proactively apply knowledge, problem-solving skills, and creative thinking in driving the project forwards.
Home Office Personal Licence, PIL A-C with rodents and hands-on experience with animal models and/or designing and overseeing in vivo experiments.
Experience with in vitro transcription (IVT) of mRNA.
Experience in design, production, and QC of viral vectors as vaccine delivery systems (AV, AAV, etc).
Experience with CRISPR based editing technology to generate stable cell lines (KO and/or KI).
Direct hands-on laboratory experience in testing and developing of biologics or vaccines.
Experience in the field of infectious diseases and microbiology.

Competitive starting salary
~ Central London location for lab and office
~ Private medical health and dental insurance
~ Opportunities for career growth and professional development
~26 days holiday leave + bank holidays
~ Enhanced sick pay
~ Family friendly policies, including enhanced maternity, paternity, and adoption leave
~ Pension plan


We are an equal opportunity employer and value diversity and inclusion in our workplace.

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