Scientist, Cell and Gene Technical Development
3 weeks ago
Location: London, UK Reporting to: Principal Scientist, Cell and Gene Technical Development Job Summary:
This is an exciting opportunity for a well-qualified candidate to join an international company focused on transforming the lives of patients with rare disorders through innovative gene therapies. Orchard Therapeutics, Ltd. (OTL) is looking for a Scientist I or II (depending on experience) for the Process Development team, focused on the development of analytical assays for Orchard Therapeutics' innovative gene-modified cell-based therapeutic products. Primary activities will include developing, validating and performing analytical assays for process development, QC and characterization of lentiviral vector and HSC gene therapy products. The post may also include research with internal departments and external partners, including development, validation and technology transfer, to support OTL's product pipeline programs. The role will be based in Orchard's London Hammersmith site where the state-of-the-art development laboratories are located.
Key Elements And Responsibilities:- Develop, validate and perform analytical assays for process development, implementation as QC and/or characterization assays for lentiviral vector and HSC gene therapy products
- Involvement in the transfer of processes and analytical methods from external collaborators and internal Orchard Research team to the Technical Development team.
- Assessment of novel equipment and methodologies for lentiviral vector and HSC DP analytics.
- Participate in the Technical Development team through generation and testing of lentiviral vectors, and involvement in the optimization and improving lentiviral vector and HSC manufacturing processes.
- Assist in lab management duties, stock management and equipment maintenance and other practical day-to-day activities in the lab.
- Keep accurate and contemporaneous records of all development activities and analysis in Orchard's electronic lab notebook, presentations and/or reports, and present to the wider team/department.
- Authoring, reviewing and editing batch records, SOPs, development protocols and reports for internal and external analytical development, and CMC regulatory submissions.
- As required, manage activities at CDMOs and CTOs for the tech transfer, development, and validation of analytical methods, including the design, review and approval of associated protocols, test records/forms, reports and SOPs.
- Other activities may be assigned as required, in agreement with line management.
Required Knowledge: As a Proven Technical Expert In The Development, Manufacture And Delivery Of Cell-based Therapy Products With Significant Applied Experience In The Biotechnology Industry, This Candidate Will Possess Experience in the biotechnology or pharma industry (including PhD or industry/academic work where relevant), with the ability to design, validate and apply analytical methods for cell and gene therapy product development, characterization and QC testing. Capable of independently designing experiments to develop analytical methods and, with support, validation and tech transfer as required. Hands-on experience of the development, validation and application of analytical techniques such as FACS, ddPCR, ELISA, DNA sequencing, qPCR/PCR, cell culture and cell-based assays. Knowledge of European and US Pharmacopeia methods and FDA, EMA, GMP, WHO and ICH regulatory requirements if preferred. Sound understanding and demonstrated application of statistical methods/tools would be advantageous.
Skills And Abilities: Excellent written and oral communication skills, excellent interpersonal skills, outstanding organizational skills, creative problem solver, ability to operate in a fast-paced, multi-disciplinary industrial environment, proven ability to work effectively in multi-site, cross-functional working environment.
Education:BSc/MSc with relevant industry experience, or PhD in biotechnology/biological sciences, gene therapy, analytical development or an associated discipline.
#J-18808-Ljbffr-
London, United Kingdom Cell and Gene Therapy Catapult Full timeThe purpose of this role is to support the development of novel cell and gene therapy medicinal products and associated technologies for multiple clients and Collaborators . Working in multidisciplinary teams, the Scientist – Technology and Process Innovation (TPI) will play a key role in delivery of projects, applying in-depth technical expertise in...
-
London, United Kingdom Cell and Gene Therapy Catapult Full timeThe purpose of this role is to support the development of novel cell and gene therapy medicinal products and associated technologies for multiple clients and Collaborators . Working in multidisciplinary teams, the Scientist – Technology and Process Innovation (TPI) will play a key role in delivery of projects, applying in-depth technical expertise in...
-
London, United Kingdom Cell and Gene Therapy Catapult Full timeThe purpose of this role is to support the development of novel cell and gene therapy medicinal products and associated technologies for multiple clients and Collaborators . Working in multidisciplinary teams, the Scientist – Technology and Process Innovation (TPI) will play a key role in delivery of projects, applying in-depth technical expertise in...
-
Non-Executive Director
4 days ago
London, United Kingdom Catapult Cell and Gene Therapy Full time €15,000The Cell and Gene Therapy Catapult (CGT Catapult) is part of a network of nine industry specific research and innovation centres established by Innovate UK to accelerate pioneering work, research and innovation, and to drive economic growth within the UK. To date the success of the Catapults has been in their ability to bring different sectors together...
-
Non-Executive Director
4 days ago
London, United Kingdom Catapult Cell and Gene Therapy Full time €15,000The Cell and Gene Therapy Catapult (CGT Catapult) is part of a network of nine industry specific research and innovation centres established by Innovate UK to accelerate pioneering work, research and innovation, and to drive economic growth within the UK. To date the success of the Catapults has been in their ability to bring different sectors together...
-
Non-Executive Director
4 days ago
London, United Kingdom Catapult Cell and Gene Therapy Full timeThe Cell and Gene Therapy Catapult (CGT Catapult) is part of a network of nine industry specific research and innovation centres established by Innovate UK to accelerate pioneering work, research and innovation, and to drive economic growth within the UK. To date the success of the Catapults has been in their ability to bring different sectors together...
-
Interim Senior Non-Clinical Manager
5 days ago
London, United Kingdom Cell and Gene Therapy Catapult Full timeThe Interim Senior Non-Clinical Manager, will advise internal and external stakeholders on strategies to assess the non-clinical characteristics (pharmacology and toxicology) of candidate cell and gene therapies and tissue engineered therapeutics, plan studies to meet the regulatory requirements, complete non-clinical gap analyses and represent the Cell and...
-
Juridisch Adviseur Arbeidsrecht
1 week ago
London, United Kingdom Cell and Gene Therapy Catapult Full timeThe In House Legal Counsel will be part of a small, friendly and supportive team of legal experts. The legal team supports across the whole of the CGT Catapult organisation, partnering with stakeholders (including the senior leadership team) to provide high quality, proactive advice that enables the organisation to execute on high impact, novel projects and...
-
Juridisch Adviseur Arbeidsrecht
4 days ago
London, United Kingdom Cell and Gene Therapy Catapult Full timeThe In House Legal Counsel will be part of a small, friendly and supportive team of legal experts. The legal team supports across the whole of the CGT Catapult organisation, partnering with stakeholders (including the senior leadership team) to provide high quality, proactive advice that enables the organisation to execute on high impact, novel projects and...
-
Juridisch Adviseur Arbeidsrecht
1 week ago
London, United Kingdom Cell and Gene Therapy Catapult Full timeThe In House Legal Counsel will be part of a small, friendly and supportive team of legal experts. The legal team supports across the whole of the CGT Catapult organisation, partnering with stakeholders (including the senior leadership team) to provide high quality, proactive advice that enables the organisation to execute on high impact, novel projects and...
-
Juridisch Adviseur Arbeidsrecht
1 week ago
London, United Kingdom Cell and Gene Therapy Catapult Full timeThe In House Legal Counsel will be part of a small, friendly and supportive team of legal experts. The legal team supports across the whole of the CGT Catapult organisation, partnering with stakeholders (including the senior leadership team) to provide high quality, proactive advice that enables the organisation to execute on high impact, novel projects and...
-
L&D Implementation Co-Ordinator
2 weeks ago
London, United Kingdom Cell and Gene Therapy Catapult Full timeWe are looking for a L&D Officer to join us for a six month fixed term contract (temp to perm). Reporting directly to the L&D HR Business Partner, the L&D Coordinator will be responsible for the L&D administrative and operational activities within the L&D function in the HR department. The L&D Coordinator will be the main point of contact for all Cell and...
-
Legal Counsel
1 week ago
London, United Kingdom Cell and Gene Therapy Catapult Full timeThe In House Legal Counsel will be part of a small, friendly and supportive team of legal experts. The legal team supports across the whole of the CGT Catapult organisation, partnering with stakeholders (including the senior leadership team) to provide high quality, proactive advice that enables the organisation to execute on high impact, novel projects and...
-
Legal Counsel
4 days ago
London, United Kingdom Cell and Gene Therapy Catapult Full timeThe In House Legal Counsel will be part of a small, friendly and supportive team of legal experts. The legal team supports across the whole of the CGT Catapult organisation, partnering with stakeholders (including the senior leadership team) to provide high quality, proactive advice that enables the organisation to execute on high impact, novel projects and...
-
Legal Counsel
2 weeks ago
London, United Kingdom Cell and Gene Therapy Catapult Full timeThe In House Legal Counsel will be part of a small, friendly and supportive team of legal experts. The legal team supports across the whole of the CGT Catapult organisation, partnering with stakeholders (including the senior leadership team) to provide high quality, proactive advice that enables the organisation to execute on high impact, novel projects and...
-
Legal Counsel
1 week ago
London, United Kingdom Cell and Gene Therapy Catapult Full timeThe In House Legal Counsel will be part of a small, friendly and supportive team of legal experts. The legal team supports across the whole of the CGT Catapult organisation, partnering with stakeholders (including the senior leadership team) to provide high quality, proactive advice that enables the organisation to execute on high impact, novel projects and...
-
Non Executive Director
4 days ago
London, United Kingdom Catapult Cell and Gene Therapy Full time €15,000The Vacancy The Cell and Gene Therapy Catapult (CGT Catapult) is part of a network of nine industry specific research and innovation centres established by Innovate UK to accelerate pioneering work, research and innovation, and to drive economic growth within the UK. To date the success of the Catapults has been in their ability to bring different sectors...
-
Non Executive Director
4 days ago
London, United Kingdom Catapult Cell and Gene Therapy Full timeThe Vacancy The Cell and Gene Therapy Catapult (CGT Catapult) is part of a network of nine industry specific research and innovation centres established by Innovate UK to accelerate pioneering work, research and innovation, and to drive economic growth within the UK. To date the success of the Catapults has been in their ability to bring different...
-
Non Executive Director
5 days ago
London, United Kingdom Catapult Cell and Gene Therapy Full time €15,000The Vacancy The Cell and Gene Therapy Catapult (CGT Catapult) is part of a network of nine industry specific research and innovation centres established by Innovate UK to accelerate pioneering work, research and innovation, and to drive economic growth within the UK. To date the success of the Catapults has been in their ability to bring different sectors...
-
PhD Research Scientist
1 week ago
London, United Kingdom Orchard Therapeutics Full timePrincipal Scientist, Cell and Gene Technical Development This is an exciting opportunity for a well-qualified candidate to join an international company focused on transforming the lives of patients with rare disorders through innovative gene therapies. OTL) is looking for a Scientist I or II (depending on experience) for the Process Development team,...
