Principal Computational Biologist

4 weeks ago

United Kingdom Ochre Bio Full time

Summary

We are looking for a talented and highly motivated Principal Computational Biologist to join Ochre Bio’s In Silico Biology team on an exciting journey to support the development of advanced RNA medicines for one of the most pressing healthcare challenges of our time.

The role will lead advanced modelling methods within a functional genomics and imaging team, with a sharp focus on generating novel target recommendations, validating them in models (including actual human livers), and translating them into RNA therapeutics for chronic liver disease.

This role will be based at Oxford Science Park. UK remote work is possible, with site visits.

Key Responsibilities

  • Lead the ‘advanced modelling’ squad within the In Silico Biology Team, and be the point of contact and a role model for advanced modelling within the company.
  • Maintain strong domain knowledge of leading ‘omics' and ‘big data’ computational methods
  • Drive experimental design & modelling of deep phenotyping and/ or omics data in close collaboration with wet-lab scientists. Work as a member of cross-functional teams bringing together best-in-class Drug Discovery, Drug Development, Product & Project Management capabilities.
  • Routinely use Python/R for data analyses, in particular data wrangling, modelling and visualisation. Develop solutions to increase automation, reliability and scalability of our data processing pipelines and workflows.
  • Lead, co-develop, and run pipelines in a cloud computing environment.
  • Maintain progress in personal and professional development to better domain, technical, and professional skills.
  • Contribute to documenting processes and code in the form of SOPs. Present research updates to project teams and to the management team.
  • Contribute to training initiatives to foster a data-driven culture.

Qualifications & Experience

Required

  • PhD in computational biology or related
  • Experience in delivering results in a fast-paced environment (biotech / pharma industries would be a distinct advantage)
  • Strong experience in developing and modifying statistical (and ML) models of ‘omics datasets for biological interpretation and actionable insights
  • Strong experience with experimental design, exploratory data analysis, reporting and visualisation of data.
  • Experience in leading projects involving multiple stakeholders, end-to-end.

Desirable

  • Experience in leading people and delivering through others
  • Experience with pipelines / reproducible scientific workflows development (i.e. Nextflow, CodeOcean)

Skills & Competencies

Required

  • Deep understanding of human biology beyond the statistical/ML models being developed
  • Good knowledge with rapidly prototyping, writing and maintaining Python and/or R code, harnessing statistical tools for biological interpretations.
  • Embracing change - this is a fast-growing start-up and change is inevitable

Desirable

  • Familiarity with project management tools (SmartSheet / JIRA/ ClickUp)
  • Familiarity with Github.
  • Familiarity with imaging ML
  • Familiarity with cloud computing (AWS)

Cultural & Working Norms

The role requires behaviours that encourage thriving in the face of failures, summarised as Ochre’s three laws.

Clarke’s Law:

“Any sufficiently advanced technology is indistinguishable from magic” (Don’t fear failure, be ambitious)

Murphy’s Law:

“What can go wrong, will go wrong.” (You will fail, learn quickly)

Wheaton’s Law:

“Don’t be a d*ck” (Others will fail you, support them)

  • Principal Computational Biologist

    4 weeks ago

    United Kingdom Ochre Bio Full time

    SummaryWe are looking for a talented and highly motivated Principal Computational Biologist to join Ochre Bio’s In Silico Biology team on an exciting journey to support the development of advanced RNA medicines for one of the most pressing healthcare challenges of our time. The role will lead advanced modelling methods within a functional genomics and...

  • Principal Computational Biologist

    4 weeks ago

    United Kingdom Ochre Bio Full time

    SummaryWe are looking for a talented and highly motivated Principal Computational Biologist to join Ochre Bio’s In Silico Biology team on an exciting journey to support the development of advanced RNA medicines for one of the most pressing healthcare challenges of our time. The role will lead advanced modelling methods within a functional genomics and...

  • Principal Computational Biologist

    3 weeks ago

    United Kingdom Ochre Bio Full time

    Summary We are looking for a talented and highly motivated Principal Computational Biologist to join Ochre Bio’s In Silico Biology team on an exciting journey to support the development of advanced RNA medicines for one of the most pressing healthcare challenges of our time. The role will lead advanced modelling methods within a functional genomics and...

  • Principal Computational Biologist

    4 weeks ago

    United Kingdom Ochre Bio Full time

    SummaryWe are looking for a talented and highly motivated Principal Computational Biologist to join Ochre Bio’s In Silico Biology team on an exciting journey to support the development of advanced RNA medicines for one of the most pressing healthcare challenges of our time. The role will lead advanced modelling methods within a functional genomics and...

  • Field Biologist

    4 weeks ago

    United Kingdom Ochre Bio Full time

    Summary We are looking for a talented and highly motivated Principal Computational Biologist to join Ochre Bio’s In Silico Biology team on an exciting journey to support the development of advanced RNA medicines for one of the most pressing healthcare challenges of our time. This role will be based at Oxford Science Park. UK remote work is possible,...

  • Field Biologist

    4 weeks ago

    United Kingdom Ochre Bio Full time

    Summary We are looking for a talented and highly motivated Principal Computational Biologist to join Ochre Bio’s In Silico Biology team on an exciting journey to support the development of advanced RNA medicines for one of the most pressing healthcare challenges of our time. This role will be based at Oxford Science Park. UK remote work is possible,...

  • Senior Computational Scientist

    3 weeks ago

    United Kingdom SRG Full time

    I am genuinely excited to be working with a cutting edge Biotech who work at the interface of engineering and cell biology to develop human biomimetic platforms for the testing and development of therapeutics for serious human diseases. They are expanding their R&D team in Cambridge and seeking a Senior Computational Scientist. Are you a senior...

  • Senior Computational Scientist

    3 weeks ago

    United Kingdom SRG Full time

    I am genuinely excited to be working with a cutting edge Biotech who work at the interface of engineering and cell biology to develop human biomimetic platforms for the testing and development of therapeutics for serious human diseases. They are expanding their R&D team in Cambridge and seeking a Senior Computational Scientist. Are you a senior...

  • Molecular biologist/Computational biologist

    2 weeks ago

    United Kingdom Carl von Ossietzky Universität Oldenburg Full time

    The School VI ofMedicine and Health Sciences includes the areas of Human Medicine, Medical Physicsand Acoustics, Neuroscience, Psychology and Health Services Research. Togetherwith the four regional hospitals the School VI forms the Oldenburg UniversityMedical Center. We also cooperate closely with the University Medical Center atthe University of...

  • Principal Performance Analysis Engineer

    4 weeks ago

    United Kingdom Endeavour Recruitment Solutions Full time

    Senior / Principal Engineer – Permanent - London ~ Software Engineer ~ Job Type: Permanent ~ Technologies: C++ 3D Maths Animation Engine Game Engine Graphics Architecture Graphics FX OpenGL Perforce Physics Dynamics Collision PS4 VR Senior / Principal Engineer – Permanent - London Posted Thursday, 12 May 2016 Endeavour Recruitment has a...

  • Senior/Principal Scientist

    3 weeks ago

    United Kingdom Cranleigh STEM, Sustainability & SHEQ Recruitment Full time

    We have an exciting opportunity for an experienced scientist to join a growing therapeutics organisation. You will contribute to cutting-edge research in the development of therapeutics for veterinary diseases. The role requires expertise in in vitro assay development, molecular pharmacology, and cell biology. As a Principal Scientist, you must also have a...

  • Principal Security Platform Engineer

    3 days ago

    United Kingdom InfoSec People Ltd Full time

    Job Post: Principal Security Architect Location: London, Hybrid (1 day per week) Type: Full-Time Our client, a highly respected and well-established household name, is seeking an experienced Principal Security Architect to join their dynamic team. This is an excellent opportunity to make a significant impact on the security posture of a leading...

  • Software Scientist

    3 weeks ago

    United Kingdom SRG Full time

    I am genuinely excited to be working with a cutting edge Biotech who work at the interface of engineering and cell biology to develop human biomimetic platforms for the testing and development of therapeutics for serious human diseases. They are expanding their R&D team in Cambridge and seeking a Senior Computational Scientist. Are you a senior...

  • Software Scientist

    3 weeks ago

    United Kingdom SRG Full time

    I am genuinely excited to be working with a cutting edge Biotech who work at the interface of engineering and cell biology to develop human biomimetic platforms for the testing and development of therapeutics for serious human diseases. They are expanding their R&D team in Cambridge and seeking a Senior Computational Scientist. Are you a senior...

  • Principal Security Researcher | Engineer

    4 weeks ago

    United Kingdom Reqiva Full time

    This is a unique position for a Principal Security Engineer | Researcher to join a global, SME and fintech platform business looking to innovate and continue to transform their approach to Security. This could suit someone who is a Principal Security Researcher | Engineer within a platform environment, however, not limited to this. Their core software...

  • Principal AI Architect

    4 days ago

    United Kingdom ACCPRO Full time

    I am partnered with one of the UK's leading AI startups and a company who are partnered with some of the biggest tech companies in the world including AWS, NVIDIA & IBM. My client are looking for a Principal AI Architect to join and help drive internal and external projects for the business. My client is UK based but you can work fully remote from anywhere...

  • Principal Hardware Engineer

    5 days ago

    United Kingdom Harnham Full time

    Principal Computer Vision Engineer (SLAM) London (Hybrid/REMOTE) This is an exciting new opportunity for a SLAM Computer Vision expert to join a DeepTech start-up! This Deep-Tech start-up is going through a funding round and growing its company substantially. They specialize in leveraging advanced computer vision techniques to process and analyze 3D...

  • Principal Data Engineer

    3 days ago

    United Kingdom Atyeti Inc Full time

    Client: A global financial services company About the Role: We are seeking a talented Principal Data Engineer to join our team in London. As a Principal Data Engineer, you will play a crucial role in developing and maintaining our data infrastructure, ensuring scalability, reliability, and efficiency. Key Responsibilities: Design, develop, and...

  • Principal AI Architect

    4 days ago

    United Kingdom ACCPRO Full time

    I am partnered with one of the UK's leading AI startups and a company who are partnered with some of the biggest tech companies in the world including AWS, NVIDIA & IBM. My client are looking for a Principal AI Architect to join and help drive internal and external projects for the business. My client is UK based but you can work fully remote from anywhere...

  • Principal AI Architect

    4 days ago

    United Kingdom ACCPRO Full time

    I am partnered with one of the UK's leading AI startups and a company who are partnered with some of the biggest tech companies in the world including AWS, NVIDIA & IBM. My client are looking for a Principal AI Architect to join and help drive internal and external projects for the business. My client is UK based but you can work fully remote from anywhere...