CLINUVEL Vitiligo Expert Panel

2 weeks ago


United Kingdom Clinuvel Pharmaceuticals Ltd Full time

World leaders in pigmentation and photodermatology to advise on afamelanotide development program, path to market

CLINUVEL has entered a formal collaboration with four of the world’s leading vitiligo experts to support clinical and scientific work and provide advice on the Company’s late-stage development of, and path to market for, SCENESSE (afamelanotide).

This is the first time CLINUVEL has entered a long-term collaboration with specialists, owing to the scientific progress in vitiligo. The experts selected are best positioned to provide advice on the future use of afamelanotide in clinical practice, presenting the drug as a non-immunogenic therapy in patients with darker skin types.

SCENESSE is being developed as the first systemic (total body) treatment for vitiligo, a complex disorder where patients lose skin pigmentation. Early clinical trials of SCENESSE showed that the drug, used in combination with narrowband ultraviolet B (NB-UVB) phototherapy, could repigment vitiligo lesions faster and more effectively than NB-UVB alone, with the best clinical response seen in patients with darker skin types (Fitzpatrick Skin Types IV-VI). 1

CLINUVEL has established a late-stage clinical trial program to assess SCENESSE as a combination therapy in vitiligo; a new study, CUV105, is expected to start treating patients later this year.


Figure 1 Repigmentation of a vitiligo patient’s legs in the CUV102 study. The patient received 55 NB-UVB treatments and four SCENESSE implants over six months. Images courtesy of the investigators. 2

The VEP comprises clinical leaders in pigmentation and photodermatology:

  • Dr Viktoria Eleftheriadou (UK) – Consultant Dermatologist at Walsall Healthcare & The Royal Wolverhampton NHS Trusts and Honorary Associate Professor at the Institute of Applied Health Research at the University of Birmingham.
  • Prof Khaled Ezzedine (France) – Professor of Dermatology at Assistance Publique – Hôpitaux de Paris and the Hôpital Henri-Mondor.
  • Dr Pearl Grimes (USA) – Director of the Vitiligo & Pigmentation Institute of Southern California and the Grimes Center of Medical and Aesthetic Dermatology, and Clinical Professor of Dermatology at the David Geffen School of Medicine at UCLA.
  • Prof Thierry Passeron (France) – Professor and Chair, Department of Dermatology, University Hospital of Nice, Professor of Dermatology at the University Côte d’Azur, and head of laboratory INSERM U1065 team 12, C3M.

The Panel will periodically meet with CLINUVEL’s scientific and clinical teams to monitor progress, undertake critical analyses, and confirm that the overall program reflects contemporary clinical and academic thinking on vitiligo.

Commentary

“Vitiligo is a notoriously difficult disorder to treat and has a devastating impact on patients,” CLINUVEL’s Chief Scientific Officer, Dr Dennis Wright said. “Recent regulatory and societal recognition of the impact of the disease has created new opportunities to progress clinical development of afamelanotide.

“By treating patients systemically, we are aiming to introduce a new standard of therapy for vitiligo patients in clinical practice. The engagement with global experts is in anticipation of the position of afamelanotide in daily dermatology practice,” Dr Wright said.

#J-18808-Ljbffr
  • Regulatory expert

    2 weeks ago


    United Kingdom Clinuvel Pharmaceuticals Ltd Full time

    World leaders in pigmentation and photodermatology to advise on afamelanotide development program, path to market CLINUVEL has entered a formal collaboration with four of the world’s leading vitiligo experts to support clinical and scientific work and provide advice on the Company’s late-stage development of, and path to market for, SCENESSE...


  • United Kingdom The Panel Full time

    Private Assets Product Delivery Senior Manager - 9 Month FTC - London Fund Manager The Panel City Of London, England, United Kingdom 3 days ago Be among the first 25 applicants Direct message the job poster from The Panel Director - Funds & Investment Management at The Panel | Shaping Exceptional Futures through Talent Leadership The Panel is currently...


  • United Kingdom The Panel Full time

    Private Assets Product Delivery Senior Manager - 9 Month FTC - London Fund Manager Director - Funds & Investment Management at The Panel | Shaping Exceptional Futures through Talent Leadership The Panel is currently engaged to source a Private Assets Product Delivery Senior Manager on behalf of a reputable Fund Manager in London city centre on a 9 Month...


  • United Kingdom Expert Employment Full time

    You'll be responsible for creating and refining a variety of motor control and power distribution panels according to client requirements. Our client operates across multiple fields including design, engineering, and construction, with a focus on power and environmental sectors. Responsibilities: Interpret clients' requirements during project...

  • Electrical Engineer

    2 months ago


    United Kingdom Electriciansforums Full time

    Discuss Electrical Engineer / Panel Wirer Needed for Contract Job Sussex in the Electrical Engineering Chat area at ElectriciansForums.net C Vacancy for the assembly & wiring of Energy Storage Systems required for an ad hoc/part time upcoming contract in Storrington (West Sussex) area. Duration of upcoming project is 6-8 weeks with the potential of...

  • Electrical Engineer

    2 months ago


    United Kingdom Electriciansforums Full time

    Discuss Electrical Engineer / Panel Wirer Needed for Contract Job Sussex in the Electrical Engineering Chat area at ElectriciansForums.net C Vacancy for the assembly & wiring of Energy Storage Systems required for an ad hoc/part time upcoming contract in Storrington (West Sussex) area. Duration of upcoming project is 6-8 weeks with the potential of...


  • United Kingdom Jameson Legal Full time

    Our client is a respected regional law firm offering their clients a full range of legal services. They have a steady workforce and broad diet of clients both private and commercial. Currently they are recruiting for an experienced solicitor or chartered legal executive to join their children law team. The team is known for its technical expertise and...

  • Family Law Solicitor

    2 hours ago


    United Kingdom Jameson Legal Full time

    Our client is a respected regional law firm offering their clients a full range of legal services. They have a steady workforce and broad diet of clients both private and commercial. Currently they are recruiting for an experienced solicitor or chartered legal executive to join their children law team. The team is known for its technical expertise and...

  • Shift Engineer

    2 weeks ago


    United Kingdom Modus Personnel Ltd Full time

    Join to apply for the Electrical Maintenance Engineer role at Modus Personnel Join to apply for the Electrical Maintenance Engineer role at Modus Personnel Sign in to save Electrical Maintenance Engineer at Modus Personnel . We have an exceptional opportunity for a seasoned Electrical Maintenance Engineer to join a renowned manufacturing...


  • United Kingdom Jameson Legal Full time

    Our client is a respected regional law firm offering their clients a full range of legal services. They are renowned for excellent client care. They have a steady workforce and broad diet of clients both private and commercial. Currently they are recruiting for an experienced solicitor or chartered legal executive to join their children law team. The team...


  • United Kingdom Jameson Legal Full time

    Our client is a respected regional law firm offering their clients a full range of legal services. They are renowned for excellent client care. They have a steady workforce and broad diet of clients both private and commercial. Currently they are recruiting for an experienced solicitor or chartered legal executive to join their children law team. The team...


  • United Kingdom TLGEC Full time €45,000 - €65,000

    Sales & Business Development Manager – Solar & Storage Energy Systems Job Type: Permanent Position: Full-time Are you a dedicated Business Development Manager with experience in sales in the renewable energy sector? If you have an excellent understanding of renewable energy project development processes and you are capable of assessing energy...


  • United Kingdom Russell Taylor Group Ltd Full time

    Do you have on site electrical experience? This role offers the chance to learn and develop your knowledge within switchgear, working on site alongside leading experts in LV switchgear. Exciting projects on a range of sectors including Data Centres and both Industrial / Commercial projects. Installation, service and maintenance of all aspects of switchgear...


  • United Kingdom Russell Taylor Group Ltd Full time

    Do you have on site electrical experience? This role offers the chance to learn and develop your knowledge within switchgear, working on site alongside leading experts in LV switchgear. Exciting projects on a range of sectors including Data Centres and both Industrial / Commercial projects. Installation, service and maintenance of all aspects of switchgear...


  • United Kingdom Together Full time

    Working Hours: Standard (09:00am-17:30pm) Department: Intermediary Oversight Office or Field Based: Office Based (Cheadle, SK8 3GW) Contract type: Permanent Company Description We’re Together – the market leading property finance experts with an entrepreneurial spirit. Based in Cheadle, South Manchester, we’ve been established since in 1974 and...


  • United Kingdom Infogain Full time

    Job Title: Peering Provisioning Engineer Location: London, UK Role Description: We have an exciting opportunity for a skilled Peering Provisioning Engineer to join our network infrastructure team, contributing to the deployment and management of our extensive peering network. This role involves maintaining and expanding our global Edge network...


  • United Kingdom Medico Legal UK Chambers Ltd (MLUK) Full time

    MLUK provides the best psychiatric and psychological expert witnesses for criminal and civil proceedings. Since our inception we’ve seen tremendous growth, because of the quality of our work. Our excellent reputation allows us to deliver on our vision. We already have a comprehensive panel of expert witnesses with a range of skills working to assist...

  • Ecotoxicologist

    1 month ago


    United Kingdom VRS Recruitment Full time

    We are looking for an ecotoxicologist / ecotoxicology specialist to join the environmental risk assessment team of an expanding chemical regulatory science consultancy. Ideally you will have existing experience of ecotoxicology evaluation of chemical / agrochemical products and substances – this could be with a competent authority, consultancy or CRO...


  • United Kingdom Unilever Deutschland Holding GmbH Full time

    Job Title: Controls & Electrical Maintenance Engineer Colworth Science Park The ice cream processing team at Colworth has an exciting vacancy for a Controls &Electrical Maintenance Engineer based at their Advanced Prototyping Engineering Centre. This role involves building control panels and electrical wiring to working specifications and ensuring...


  • United Kingdom Russell Taylor Group Ltd Full time

    Are you looking for a role based in London? Do you have on site electrical experience? Would you like to work for a company established 50 years ago? This role offers the chance to learn and develop your knowledge within switchgear, working on site alongside leading experts in LV switchgear. Exciting projects on a range of sectors including Data Centres and...