Commercial Bioinformatician

Oxford Nanopore Technologies is headquartered at the Oxford Science Park outside Oxford, UK, with satellite offices and commercial presence in many global locations across the US, APAC and Europe. Oxford Nanopore employs from multiple subject areas including nanopore science, molecular biology and applications, informatics, engineering, electronics, manufacturing and commercialisation. The management team, led by CEO Dr Gordon Sanghera, has a track record of delivering disruptive technologies to the market.
Oxford Nanopore’s sequencing platform is the only technology that offers real-time analysis (for rapid insights), in fully scalable formats from pocket to population scale, that can analyse native DNA or RNA and sequence any length of fragment to achieve short to ultra-long read lengths.
This is an exciting new role in the Customer Workflows team to help us support the work in organisation to help bring end-to-end products to market. 
The Bioinformatics analyst will work within both the Customer Analysis Workflows and Applied Development groups. The bioinformatics analyst will provide day to day analysis support of sequencing data during development these products. The analyst will collaborate with workflow developers and laboratory scientists to ensure a robust and coherent set of analysis software tools for end users of the ONT/OND sequencing platform. There will be a particular focus on testing and validation of bioinformatics analysis workflows for clinical and regulated applications that meet ISO standards. The role requires an individual to leverage computational and analytical techniques to extract meaningful insights from biological data. They will work with laboratory scientists during assay development to feedback key performance metrics. They will ensure the use of an appropriate structured framework to document the outcomes of the evaluation process, which will then be used by developers to improve and refine workflow software. Run EPI2ME workflows to perform data analysis of complex datasets, across a number of applications within rare disease, cancer, and infectious disease
• Carry out validation and verification and generate metrics to monitor the performance of EPI2ME workflows and associated tools, including sensitivity and specificity calculations
• Carry out validation and verification and generate metrics to monitor the performance of laboratory workflows, including sensitivity and specificity calculations
• Interpret the results of genomics data analysis using statistical techniques, and provide ongoing reports to monitor sequencing performance over time
• Work with data science colleagues in the Product Performance group to establish in-field monitoring of products
• Maintain knowledge of external advances in the field of long-read data analysis
• Maintain knowledge of relevant bioinformatics tools and software
• Develop and implement databases, data collection systems, data analytics and other strategies that optimise efficiency and quality of analyses performed
• Work collaboratively with laboratory scientist, workflow developers and other data analysts to refine analysis code and improve workflow performance

 
An MSc (or equivalent experience) involving a substantial amount of bioinformatics and/or data analysis
Practical experience with the processing and analysis of large genomic datasets, and their associated metadata
Practical experience handling sequencing data with exposure to the commonly used software tools (samtools, bcftools), algorithms (alignment, assembly), and file formats (FASTQ, BAM, VCF)
Familiarity with long-read sequencing data analysis
We offer outstanding benefits to include an attractive bonus, generous pension contributions, private healthcare and an excellent starting salary. Based within beautiful, landscaped surroundings with tree-lined walks, water features and a lake, all of which make for a wonderful working environment. Please note that no terminology in this advert is intended to discriminate on the grounds of a person's gender, marital status, race, religion, colour, age, disability or sexual orientation. We will ensure that individuals with disabilities are provided reasonable accommodation to participate in the job application or interview process, to perform essential job functions, and to receive other benefits and privileges of employment. Please contact us to request accommodation.
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