Leader of DMPK and Physical Sciences, London

3 weeks ago

London, United Kingdom Isomorphic Labs Limited Full time

Leader of DMPK and Physical Sciences , Lon don

Isomorphic Labs is a new Alphabet company that is reimagining drug discovery through a computational- and AI-first approach.

We are on a mission to accelerate the speed, increase the efficacy and lower the cost of drug discovery. You'll be working at the cutting edge of the new era of 'digital biology' to deliver a transformative social impact for the benefit of millions of people.

Come and be part of a multi-disciplinary team driving groundbreaking innovation and play a meaningful role in contributing towards us achieving our ambitious goals, while being a part of an inspiring, collaborative and entrepreneurial culture.

Your impact

This is an exciting opportunity to work closely with world leading AI and ML experts to develop imaginative new ways to predict ADMET and human dose to drive projects forward. You will have accountability for all the ADMET strategies from early Drug Discovery through to Candidate Selection and ultimately to Clinical Phase work across numerous therapeutic areas.

We are seeking a candidate who is highly experienced, with significant management experience, working across drug discovery projects, driving them to Candidate Selection and preferably to clinical phases of development.

What you will do
  • Set the company DMPK strategy across the project portfolio
  • Lead a small team of DMPK scientists to deliver on Drug Discovery projects
  • Work with CROs to deliver the highest quality ADMET data and reports
  • Distil ADMET data into actionable insights for project leaders, project team members, and potential collaborators
  • Be closely integrated in projects to provide strategic input into the project direction
  • Prepare relevant internal and regulatory documentation for preclinical and clinical work
  • Apply PK-PD modelling work to set dosing strategies for in vivo efficacy models, and to provide early human dose projections
  • Work cross functionally with Medicinal Chemistry, Biology, and Technology groups
Skills and qualifications Essential:
  • BSc, MSc or PhD in Biochemistry/Chemistry/Pharmacology/Pharmacokinetics and likely be highly experienced (>10 years) in the pharmaceutical industry
  • Expert knowledge are DMPK concepts such as Tier 1/2 ADMET assays, Transporters, Drug Metabolising Enzymes and Transformations, IVIVC/IVIVE, Pharmacokinetics, PK-PD relationships, mechanistic and allometric scaling approaches to Human Dose Projections
  • Proven track record of influence on projects such as de-risking strategies, anticipating longer term issues, solving ADMET issues and driving change in Medicinal Chemistry SAR strategies
  • Experience of working in multiple therapeutic areas and by multiple routes of administration
  • Experience working with Toxicology, Translational, Formulation, Clinical Pharmacology in setting clinical strategies
  • Experience leading the DMPK group/department
  • Driven and focussed mindset to achieve the goal of Candidate delivery in the most efficient manner through robust discussions with key stakeholders and project leaders
  • Dynamic, agile, and flexible individual who can work across therapeutic areas, and multi-disciplinary teams
  • Experience working with and assisting CROs in acquiring high quality ADMET data in a timely manner
  • Collaborative and inclusive mindset to partner across teams to drive shared learning
Nice to have:
  • Experience working for a CRO providing ADMET services
  • Knowledge/Concept of computational chemistry machine learning modelling
  • Good understanding of Medicinal Chemistry concepts and comfortable discussing small molecule approaches and strategies
  • Experience working with Data Science groups in setting up assay templates for ingestion of ADMET data
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