Analytical Scientist

2 weeks ago


Stone Cross East Sussex, United Kingdom Russell Tobin Full time

Job Description

Analytical Scientist – 12 months contract – Sandwich - £19.46 per hour PAYE or £21.81 per hour Umbrella

The Materials Characterisation Team based within the Analytical Technology Function is looking for a scientist to support the quantitation of small molecule impurities using liquid chromatography with mass spectrometry. This is to enable technical support for complex analytical and process investigations along with the assessment and support of on-market products in the areas of non-conforming materials, line extensions and second sourcing activities.

SKILLS NEEDED:

• Technical understanding of the development and validation of LC-MS methods.

• Appreciation of challenges associated with the analysis of trace impurities in pharmaceutical materials.

• Strong working knowledge of quantitative chromatographic analysis and the necessary laboratory skills required to achieve accurate, precise, and reliable data first time.

• Ability to work independently, and to document analytical results and conclusions through presentations and technical reports.

• Oral and written communication skills, with emphasis on clarity of communication.

• Ability to follow scientific protocols / methods, and departmental procedures, with excellent attention to detail.

• Highly motivated, self-directed, and pro-active.

• Creative, entrepreneurial attitude, with appetite to work in a fast-paced environment.

• Ability to execute key priorities to timelines whilst effectively balancing multiple priorities.

• Interpersonal skills and ability to work with personnel at all levels.

ROLE RESPONSIBILITIES:

Responsibilities will include, but are not limited to, the following:

• Supporting the LC-MS testing of drug product lots for the quantitation of small molecule impurities.

• Designing studies to evaluate method suitability (linearity, accuracy, precision etc.).

• Developing appropriate sample preparation methods in a range of different matrices.

• Executing accelerated drug product stability studies, including trending of impurities data.

• Performing experiments in accordance with good laboratory practices (GLP), established business processes and protocols, and applicable SOPs.

• Identifying and investigating atypical analytical results.

• Troubleshooting analytical instrumentation.

• Documenting laboratory work in a detailed, clear and timely manner, in compliance with GLP requirements.

• Selecting appropriate presentation techniques for analytical datasets in order to deliver concise headline results to stakeholders in a timely manner.

QUALIFICATIONS:

• Must have

  • Bachelor's Degree in relevant scientific field.
  • Practical analytical laboratory experience in the field of quantitative chromatographic analysis.

• Desirable

  • Experience with LC-MS and associated quantitative processing software.
  • Experience in the development / validation of LC-MS methods for trace analysis.
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