OligoTune Co-Founder: Improving responses to immunotherapy
1 month ago
At DSV we’re looking for future Founders, entrepreneurially minded individuals with industry-specific technical and commercial domain expertise eager to solve urgent unmet challenges through venture building.
Loïc Roux , who has been building the company OligoTune through DSV’s venture creation programme as a Founder-in-Residence. Over the last 10 months, Loïc has worked with DSV, devising and de-risking a novel RNA-based approach to overcome immune suppression in the tumour microenvironment. Stevel Powell , alongside a growing scientific advisory board.
Immunotherapies, especially antibody-based immune checkpoint inhibitors (ICIs) and CAR-T cell therapy have revolutionised cancer treatment with incredible results in a subset of solid tumours and in blood cancers, respectively. Despite this widely recognised success and paradigm shift in cancer treatment, these therapies still only increase median patient survival by limited degrees, often by only 10-20% vs. The lack of TME-specific cell markers means that targeted approaches (e.g. to inhibit or deplete TME cell types) incur significant autoimmune-like side effects on the same cells in other parts of the body, rendering these therapies intolerable or unusable in a substantial proportion of patients – an issue that typically compounds with combinatorial immunotherapies.
WHAT WE ARE BUILDING
The collaboration with Cancer Research Horizons Therapeutic Innovation brings a highly-skilled team of scientific leaders and hands-on experts to drive the creation of this venture and realise a streamlined pathway for this therapeutic approach to the clinic. DSV will provide ongoing support in venture creation and growth throughout the process, and experimental work will be supported through in-kind contributions at Cancer Research Horizons’ state-of-the-art research facilities in Cambridge, UK.
We are looking for a passionate and motivated co-founder with strong scientific expertise and track-record in immunology or immuno-oncology, to drive forward the science of this early-stage biotech. The successful candidate will co-lead this company and be a key player in driving the company vision, strategy and market positioning, as well as in conducting and overseeing research and development activities. Providing scientific leadership and expertise in immunology and immuno-oncology, guiding the strategic direction of research and development efforts to advance the company's scientific objectives;
Designing, refining and optimising the experimental work plan to ensure successful execution and generation of high-quality scientific data;
Crafting compelling data packages and presentations for investor conversations;
Taking responsibility for the financial planning, resource allocation, and management of projects and contractual research;
Ensure compliance with regulatory requirements and standards relevant to immunology and immuno-oncology
Identifying and mitigating risks, making informed decisions based on scientific evidence and company considerations, and adapting strategies as needed
Overall, the co-founder will play a pivotal role in shaping the scientific direction, growth, and success of the company, driving forward the science of immunology and immuno-oncology to make meaningful contributions to patients' lives.
You have a PhD and/or MD background in immunology or immuno-oncology.
A deep understanding of cancer immunotherapy mechanisms and associated challenges at the biological, clinical, technical, regulatory and competitive levels.
You are innovative, creative, and guided by first-principles thinking
Bioinformatics and data analysis skills
Track record of high quality publications in the field, or thought leadership in the field
High level industry experience in either pharma, biotech, scientific start-ups, life sciences consulting, life sciences VC, or have previously been an inventor/contributor on patents, etc.
Fundraising and commercial expertise, particularly in a VC setting
2/3 of the team have founded or led a company at C-suite and 65% have a PhD. Our team dedicate several hours every week to each Founder or founding team to provide tailored guidance, resources and feedback covering every aspect of what it takes to successfully launch a new venture from both the tech and commercial perspectives:
We provide optimised, purpose-built, proprietary tools, resources and processes to help create high-impact ventures from scratch, using our venture creation methodology.
We draw on opportunity area specific know-how provided by our network of Partners and Advisors;
We provide £250k launch investment (subject to Investment Committee approval) to incorporate the new venture and develop early proof-of-concept data that’s needed to attract high profile VCs as well as non-dilutive grant funding. We provide guaranteed income of £4,166 per month paid to each Founder-in-Residence as a consultancy fee until the company is launched and the pre-seed investment is secured;
We provide continuous support after post spin-out, including fundraising, commercial partnerships, recruitment and team-building (amongst other things); His experience comes from prestigious institutions in the nucleic acid field including The RNA Therapeutics Institute at UMass Med School and Oxford University, where he pushed forward research programs in neurodegenerative and neuromuscular diseases. After a position as principal scientist at PepGen Ltd promoting a peptide delivery platform for nucleic acid delivery, he contributed to building and establishing NATA, a new UKRI initiative aiming to promote the development of nucleic acid therapeutics. He then moved back to industry as Director of Lead Development for OchreBio, a Phenomics-led RNA medicines company developing the next-generation of RNA therapeutics for chronic liver diseases where he built oligonucleotide and new modalities chemistry capabilities, alongside efficacy and toxicity biology capabilities, to collaborate on programs including target screens, translational model development from primary cells to human organs, delivery methodology for specific cell types including HCC cancer cells, and led innovation programs for IP generation and scientific strategy.
Deep Science Ventures is creating a future in which both humans and the planet can thrive.
We use our unique venture creation process to create, spin-out and invest into science companies, combining available scientific knowledge and founder-type scientists into high-impact ventures.
We operate in 4 sectors: Pharmaceuticals, Climate, Agriculture and Computation, tackling the challenges defining those areas by taking a first principles approach and partnering with leading institutions.
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London, United Kingdom Deep Science Ventures Limited Full time €250,000At DSV we’re looking for future Founders, entrepreneurially minded individuals with industry-specific technical and commercial domain expertise eager to solve urgent unmet challenges through venture building. Loïc Roux , who has been building the company OligoTune through DSV’s venture creation programme as a Founder-in-Residence. Over the last 10...
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London, United Kingdom Deep Science Ventures Limited Full timeAt DSV we’re looking for future Founders, entrepreneurially minded individuals with industry-specific technical and commercial domain expertise eager to solve urgent unmet challenges through venture building. Loïc Roux , who has been building the company OligoTune through DSV’s venture creation programme as a Founder-in-Residence. Over the last 10...
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London, United Kingdom Jobleads-UK Full timeABOUT THE ROLEAt DSV we’re looking for future Founders, entrepreneurially minded individuals with industry-specific technical and commercial domain expertise eager to solve urgent unmet challenges through venture building.You will be joining a newly incorporated company as a Co-Founder, working closely with Dr. Loïc Roux, who has been building the...
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London, United Kingdom Deep Science Ventures Limited Full time €250,000ABOUT THE ROLE At DSV we’re looking for future Founders, entrepreneurially minded individuals with industry-specific technical and commercial domain expertise eager to solve urgent unmet challenges through venture building. You will be joining a newly incorporated company as a Co-Founder, working closely with Dr. Loïc Roux , who has been building the...
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London, United Kingdom Deep Science Ventures Full timeABOUT THE ROLEAt DSV we’re looking for future Founders, entrepreneurially minded individuals with industry-specific technical and commercial domain expertise eager to solve urgent unmet challenges through venture building.You will be joining a newly incorporated company as a Co-Founder, working closely with Dr. Loïc Roux, who has been building the...
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London, United Kingdom Deep Science Ventures Limited Full time €250,000ABOUT THE ROLE At DSV we’re looking for future Founders, entrepreneurially minded individuals with industry-specific technical and commercial domain expertise eager to solve urgent unmet challenges through venture building. You will be joining a newly incorporated company as a Co-Founder, working closely with Dr. Loïc Roux , who has been building the...
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London, United Kingdom Deep Science Ventures Limited Full timeABOUT THE ROLE At DSV we’re looking for future Founders, entrepreneurially minded individuals with industry-specific technical and commercial domain expertise eager to solve urgent unmet challenges through venture building. You will be joining a newly incorporated company as a Co-Founder, working closely with Dr. Loïc Roux , who has been building...
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London, United Kingdom Deep Science Ventures Limited Full time €250,000ABOUT THE ROLE At DSV we’re looking for future Founders, entrepreneurially minded individuals with industry-specific technical and commercial domain expertise eager to solve urgent unmet challenges through venture building. You will be joining a newly incorporated company as a Co-Founder, working closely with Dr. Loïc Roux , who has been building the...
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London, United Kingdom Deep Science Ventures Limited Full time €250,000ABOUT THE ROLE At DSV we’re looking for future Founders, entrepreneurially minded individuals with industry-specific technical and commercial domain expertise eager to solve urgent unmet challenges through venture building. You will be joining a newly incorporated company as a Co-Founder, working closely with Dr. Loïc Roux , who has been building the...
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London, United Kingdom Jobleads-UK Full timeABOUT THE ROLEAt DSV we’re looking for future Founders, entrepreneurially minded individuals with industry-specific technical and commercial domain expertise eager to solve urgent unmet challenges through venture building.You will be joining a newly incorporated company as a Co-Founder, working closely with Dr. Loïc Roux, who has been building the...
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London, United Kingdom Deep Science Ventures Full timeABOUT THE ROLEAt DSV we’re looking for future Founders, entrepreneurially minded individuals with industry-specific technical and commercial domain expertise eager to solve urgent unmet challenges through venture building.You will be joining a newly incorporated company as a Co-Founder, working closely with Dr. Loïc Roux, who has been building the...
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