Proteomics Bioinformatician

Job Details: Proteomics Bioinformatician

Full details of the job.

Vacancy Name

Vacancy No

Vacancy No VN370

Employment Type

Employment Type Permanent

Location of role

Location of role Abingdon

About the Company

About the Company Immunocore (NASDAQ: IMCR) is a pioneering, commercial-stage T cell receptor biotechnology company whose purpose is to develop and commercialize a new generation of transformative medicines which address unmet patient needs in oncology, infectious diseases and autoimmune disease. Our leaders in R&D are internationally recognised as some of the biotech industry’s most successful drug developers. We are creating not just an environment where great minds can interact but an innovation powerhouse answering the big questions.

Focused on delivering first-in-class biological therapies to patients, we have developed a highly innovative soluble TCR platform. Our ImmTAX molecules underpin a new generation of precision engineered drugs that harness the immune system to treat a broad spectrum of diseases with high unmet medical need, including oncology, infectious diseases and autoimmune diseases.

We strive to create a diverse and inclusive workplace, while seeking talented individuals to work with us across the many functions that will allow us to deliver new medicines to transform the lives of patients. You will work with outstanding people who together pioneer the research, development and commercialization of bi-specific TCR therapies. We aim to create an environment where individual contributions and initiatives can be maximized, while fostering a culture of collaboration, based on respect and integrity. We want each individual employee to own their career, as part of high-performing teams, and in the context of on-the-job and formal continuous development and training, as well as constructive feedback. We always strive to identify ways to improve what we do and how we do it, by asking questions, voicing opinions, exploring various approaches and staying connected with healthcare professionals, patients, academia and other key partners.

Key Responsibilities

Key Responsibilities MAIN PURPOSE OF JOB

To provide focused bioinformatics expertise to support the analysis and data management of mass spectrometry-based data. This individual will work with the Data Science team to develop tools and workflows to assist the proteomics department with the analysis of large immunopeptidomic datasets. In addition, the individual will support the maintenance and development of the HLA peptide database and associated tools which permit integration with transcriptomics/genomics data sources.

KEY RESPONSIBILITIES

• Work with the Data Science and Proteomic teams to maintain a database of HLA peptides based on in house mass spectrometry data.
• Assist in applying cutting edge approaches to discover peptide target candidates.
• Support development of tools and workflows to help the Proteomics department (and other departments across the organization) interrogate the data present in the HLA peptide database and any other data generated by mass spectrometry.
• Test and aid development of tools to allow for the analysis of large Proteomics/Immunopeptidomics datasets.
• Benchmark new software (both commercial and open source) for the analysis of mass spectrometry data.
• Support development and implementation of quality control analytics of proteomics and mass spectrometry data.
• Develop web apps to allow scientists to interact with data
• Maintaining and increasing technical knowledge in relevant fields through self-study, observation, attending relevant conferences and training courses.
• Maintaining accurate records of all work by completing documentation on time, following Company procedures
• Operating in accordance with the Company’s Health and Safety policies.

EXPERIENCE AND KNOWLEDGE

Essential

• Will be proficient in R/BioConductor, Linux OS and shell scripting bash. Proven programming ability
• Understanding of molecular biology, cell biology, immunology or related discipline.
• Presented detailed scientific findings and papers to internal and external audiences.
• Must be able to communicate on a technical level with other scientists from unrelated disciplines.
• Self-motivated; demonstrated success in delivering assigned tasks according to timelines.
• Problem-solve.
• Enjoy working in a fast-paced environment as part of a motivated team.

Desirable

• Theoretical and practical experience with the analysis of mass spectrometry/ Proteomics data
• Experience of independent research in academic or industrial setting, or transferable skills gained from professional experience.
• Experience in developing R Shiny apps.
• May have experience of developing databases, using SQL or similar, and pairing with a user-friendly interface.
• Mentored and coached less experienced colleagues in scientific practices and theory.
• May have knowledge of machine learning, applied statistics or related field.

EDUCATION & QUALIFICATIONS

• Essential: MSc. in bioinformatic related discipline with additional academic/industrial experience
• Desirable: PhD in related discipline #J-18808-Ljbffr

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