Scientist III/IV: DSP Manufacturing

2 weeks ago

Cambridge Cambridgeshire, United Kingdom 4basebio Full time

4basebio is an innovative gene synthesis company with the ambition to provide high quality, synthetic DNA for use in gene therapy and vaccine platforms. We are expanding our teams at our premises just North of Cambridge, UK, to continue supporting the GMP production of our DNA products for use as a starting material in mRNA and viral vector production as well as an API for use in drug products.

We are seeking for a highly skilled and motivated Downstream Processing Manufacturing Scientist to join our team in a Good Manufacturing Practices (GMP) environment. The ideal candidate will have a strong background in bioprocessing, particularly in downstream operations for biopharmaceuticals including purification and formulation process.

The role will involve performing downstream process development experiments to assure that the process is robust, scalable, and able to be performed in the manufacturing facility – as well as the accompanying documentation. The successful candidate will be familiar with cGMP and GDP regulations and technology transfer tasks.

This position requires great attention to detail, ability to work in a team environment and a keen interest in optimisation of processes. Scientists will be responsible for adhering to all Quality Management System procedures, safety policies, and relevant parts of cGMP.

Responsibilities:

  • Perform as a key member of the Downstream Manufacturing team, liaising with Process development and QA teams
  • Design and optimize downstream processing steps, including DNA purification techniques such chromatography, tangential flow filtration and formulation
  • Wide experience using AKTA systems, TFF system and deep understanding of DSP processes from a technical point of view
  • Stay up to date with current technologies and literature as well as evaluating these new technologies/processes for implementation
  • Provide hands-on supporting during manufacturing campaigns, including troubleshooting and resolving production issues
  • Assist with tech transfer activities from the Process development department to the cGMP manufacturing facility
  • Generate documentation, such as reports/experimental write-ups, that support the validation of processes and during the production’s campaigns
  • Execute and deliver projects to a high standard and in accordance with project validation plans
  • Analyse data from experiments, interpret results and implement processes
  • Record experimental methods and results to a high standard and in-line with company guidelines, maintaining QMS documentation as necessary
  • Attend and participate in relevant meetings, training, and development sessions
  • Use, maintain and respect company equipment in accordance with the company’s SOPs and health & safety guidelines
  • Train and mentor junior staff in downstream processing techniques and GMP practices
  • Undertake any other appropriate roles and responsibilities that reasonably fall within the role holder’s skills and experience as requested

Person Specification:

  • MSc in Biochemical engineering (or similar) or BSc in biological sciences, or a related discipline with relevant industry experience (2+ Years)
  • Experience of working in downstream processing in controlled environments employing quality standards (e.g., ISO, cGMP, cGLP, cGCP)
  • Experience with Chromatographic process development using AKTA systems
  • Experience with scale up and/or tech transfer of chromatographic processes would be desirable
  • Experience with TFF systems
  • Experience of experimental planning, experimental validation and report writing
  • Experience in analysis of chromatographic data and understanding the implications of certain product impurities
  • Familiarity with regulatory requirements for biopharmaceutical manufacturing
  • DoE experience using software packages such as JMP would be desirable but not essential
  • A creative and open mindset to tackle novel challenges
  • Excellent team working and communication skills
  • Excellent record keeping skills
  • Must have right to work in the UK

What we can offer:

Competitive salary + comprehensive benefits package

If you are interested in joining the 4basebio team, please forward your CV to HR@4basebio.com

This role is located in Over, North of Cambridge

No agencies please.

Due to the high number of applicants, if you do not hear back from us within six weeks, we thank you for your interest, but please assume you have not been selected for interview on this occasion.

  • Scientist III/IV: DSP Manufacturing

    3 weeks ago

    Cambridge, United Kingdom 4basebio Full time

    4basebio is an innovative gene synthesis company with the ambition to provide high quality, synthetic DNA for use in gene therapy and vaccine platforms. We are expanding our teams at our premises just North of Cambridge, UK, to continue supporting the GMP production of our DNA products for use as a starting material in mRNA and viral vector production as...

  • Scientist III/IV: DSP Manufacturing

    2 weeks ago

    Cambridge, United Kingdom 4basebio Full time

    Job Description4basebio is an innovative gene synthesis company with the ambition to provide high quality, synthetic DNA for use in gene therapy and vaccine platforms. We are expanding our teams at our premises just North of Cambridge, UK, to continue supporting the GMP production of our DNA products for use as a starting material in mRNA and viral vector...

  • Scientist III/IV: DSP Manufacturing

    3 weeks ago

    Greater Cambridge Area, United Kingdom 4basebio Full time

    4basebio is an innovative gene synthesis company with the ambition to provide high quality, synthetic DNA for use in gene therapy and vaccine platforms. We are expanding our teams at our premises just North of Cambridge, UK, to continue supporting the GMP production of our DNA products for use as a starting material in mRNA and viral vector production as...

  • Scientist III/IV: DSP Manufacturing

    2 weeks ago

    Greater Cambridge Area, United Kingdom 4basebio Full time

    4basebio is an innovative gene synthesis company with the ambition to provide high quality, synthetic DNA for use in gene therapy and vaccine platforms. We are expanding our teams at our premises just North of Cambridge, UK, to continue supporting the GMP production of our DNA products for use as a starting material in mRNA and viral vector production as...

  • Cleanroom Scientist Iii

    10 hours ago

    Cambridge, United Kingdom taylorollinson Ltd Full time

    **Cleanroom Scientist III** **Location**:Cambridge **Contract**:Full-time and permanent **Sector**:Biotechnology **Salary**:c£30,000 - £35,000 depending on experience, this may differ. **Work Hours**:40 hrs a week, Monday to Friday (09:00 - 17:30) Our client is an innovative biotechnology company based outside of the centre of Cambridge. They have...

  • Associate Scientist Iii

    5 days ago

    Cambridge, United Kingdom Orion Full time

    **Job description**: **Associate Scientist III** **Cambridge, MA** **6+ months initial contract** **Hourly Pay Rate: $37-40/hr** **Work Schedule: Monday to Friday, 9am-5/6pm EST** Orion Group is seeking an experienced Scientist to work with our global pharmaceutical client in Cambridge, MA. **Responsibilities**: - Design experiments and testing...

  • Manufacturing Scientist

    3 weeks ago

    Cambridge, United Kingdom CV-Library Full time

    Manufacturing Scientist (AKTA) Location – Cambridge Sector – Biotechnology Salary – £26,000 - £29,000 Full time, permanent role Do you have experience with downstream manufacturing processes within a biotech setting? Have you worked within a cleanroom environment? We are currently offering the opportunity for a scientist to...

  • Scientist II: Manufacturing

    2 weeks ago

    Cambridge, Cambridgeshire, United Kingdom 4basebio Full time

    4basebio is an innovative gene synthesis company with the ambition to provide high quality, synthetic DNA for use in gene therapies and gene vaccines. The company is setting up a new research and development team at our offices in Cambridge, UK to facilitate the scaling and optimisation of our proprietary DNA manufacturing process. We are looking for dynamic...

  • Senior R&d Scientist

    7 days ago

    Cambridge, United Kingdom CK GROUP Full time

    CK Group is recruiting for a Senior R&D Scientist to specialise in the development of advanced Bioseperation products, based at our clients' site in Cambridge, on a permanent basis. **About the company**: Our client is one of the largest volume affinity adsorbent manufacturers in the world, with facilities in the UK and USA. They specialise in the research,...

  • Senior Manufacturing Scientist

    3 weeks ago

    Cambridge, United Kingdom CV-Library Full time

    Senior Manufacturing Scientist (AKTA / TFF) Location – Cambridge Sector – Biotechnology Salary – £35,000 - £38,000 (depending on interview performance & experience) Full time, permanent role Do you have experience with downstream manufacturing processes within a biotech setting? Have you worked within a cleanroom...

  • Scientist II: Manufacturing

    3 weeks ago

    Cambridge, United Kingdom 4basebio Full time

    4basebio is an innovative gene synthesis company with the ambition to provide high quality, synthetic DNA for use in gene therapies and gene vaccines. The company is setting up a new research and development team at our offices in Cambridge, UK to facilitate the scaling and optimisation of our proprietary DNA manufacturing process. We are looking for dynamic...

  • Manufacturing Research Materials Scientist

    3 weeks ago

    Cambridge, Cambridgeshire, United Kingdom Alexander Daniels Global Full time

    At Alexander Daniels Global, we are seeking a highly skilled Manufacturing Research Materials Scientist to join our research team in Cambridge. This exciting opportunity involves developing high-temperature materials and advancing additive manufacturing through experimental and simulation methods.The successful candidate will be responsible for:Experimental...

  • Scientist/senior Scientist, Process Development

    4 days ago

    Cambridge, United Kingdom TEC PARTNERS LIMITED Full time

    My client, an award-winning spin-out from the University of Cambridge, with their breakthrough technology combining synthetic biology focusing on a scalable technology platform capable of producing consistent batches of mammalian cells. This potential willunlock a new generation of medicine and will allow the research and drug development sectors to work...

  • Production Scientist

    4 days ago

    Cambridge, United Kingdom Oxford Gene Technology Full time

    Are you looking for the next step in your career at OGT? Or perhaps you know someone who would be a great fit for our Company and would like to explore joining us? If so, read on and find out more about our latest opportunity as a Production Scientistin our Cambridge based Operations Team. Our Production Scientists are hardworking and organised team players,...

  • Production Scientist

    5 days ago

    Cambridge, United Kingdom Oxford Gene Technology Full time

    **Production Scientist** Are you looking for the next step in your career at OGT? Or perhaps you know someone who would be a great fit for our Company and would like to explore joining us? If so, read on and find out more about our latest opportunity as a Production Scientist in our Cambridge based Operations Team. Our Production Scientists are hardworking...

  • Scientist Research and Development

    2 weeks ago

    Cambridge, Cambridgeshire, United Kingdom 4basebio Full time

    4basebio is an innovative gene synthesis company with the ambition to provide high quality, synthetic DNA for use in gene therapies and gene vaccines. The company is setting up a new research and development team at our offices in Cambridge, UK to facilitate the scaling and optimisation of our proprietary DNA manufacturing process. We are looking for dynamic...

  • Production Scientist

    5 days ago

    Cambridge, United Kingdom Oxford Gene Technology Full time

    Are you looking for the next step in your career at OGT? Or perhaps you know someone who would be a great fit for our Company and would like to explore joining us? If so, read on and find out more about our latest opportunity as a Production Scientist in our Cambridge based Operations Team. Our Production Scientists are hardworking and organised team...

  • Cleanroom Scientist

    10 hours ago

    Cambridge, United Kingdom taylorollinson Ltd Full time

    **Production Scientist** **Location**:Cambridge **Contract**:Full-time and permanent **Sector**:Biotechnology **Salary**:c£25,000 depending on experience, this may differ. **Work Hours**:40 hrs a week, Monday to Friday (09:00 - 17:30) Our client is an innovative biotechnology company based outside of the centre of Cambridge. They have built a platform...

  • Postdoctoral Research Associate

    7 months ago

    Cambridge, United Kingdom University of Cambridge Full time

    Fixed-term: The funds for this post are available for 1 years in the first instance. You will characterise the performance of these devices using precision optical and electrical measurements including dark IV, light IV, EQE and ellipsometry. You will perform optical and device simulation and correlate with measurements to interpret results, diagnose...

  • DNA Purification Process Developer

    2 weeks ago

    Cambridge, Cambridgeshire, United Kingdom 4basebio Full time

    About the JobWe are looking for a highly motivated and experienced Downstream Processing Manufacturing Scientist to join our team in a GMP environment.Key Responsibilities:Liaise with Process development and QA teams to ensure seamless communication and collaboration.Design and optimize downstream processing steps, including DNA purification techniques such...