Target Validation Scientist

1 month ago


London, United Kingdom Hlx Life Sciences Full time

The Role

We have an exciting opportunity for a Scientist to join our cutting-edge experimental laboratory and contribute to our drug discovery initiatives. The successful candidate will be supporting and executing target validation experiments, generating and interpreting scientific data, and supporting the maintenance of the laboratory. Your contributions will be part of advancing our research and ensuring successful project outcomes.

You will join a team of talented professionals, including wet-lab scientists and data scientists and gain exposure to a diverse range of skills, both in and outside of your primary area of expertise. You will have the opportunity to contribute to the development of our positive and inclusive organisational culture and ultimately, make a positive impact on patients' lives.



Role Responsibilities

  • Scientist proficient in cellular and molecular biology to contribute to projects focussed on understanding novel target biology
  • Contribute to orthogonal validation projects by maintenance of cell lines, utilisation of CRISPR/Cas9 gene editing & microscopy endpoints
  • Work within the team to design, optimise and establish 3D multicellular and other complex cellular models that closely mimic human tissue architecture and disease states to permit the interrogation of novel target biology.
  • Generate, analyse & contribute biological data to Relations novel drug discovery projects. Working as a member of the lab team to ensure efficient running of the lab, including a variety of responsibilities as required.


Professionally, you have


  • An MSc with 1-2 years experience or PhD, with demonstrable experience in assay development and/or target validation.
  • Experience with a variety of mammalian cellular models including established cell lines, patient-derived primary cells and the development of 2D or 3D multicellular assays, with functional disease relevant endpoints with the aim of ensuring required reproducibility and sensitivity in those assays.
  • Experience using multi-parameter endpoints including, but not limited to flow cytometry, fluorescence microscopy, plate based fluorescent assays, soluble ligand analysis, RT-qPCR.
  • Knowledge of gene editing tools (e.g., CRISPR/Cas9) and RNA interference for modulating gene expression in 2D and 3D cell systems.
  • A proven ability to work closely within cross-functional teams to progress target validation projects and present findings to internal stakeholders.


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