Formulation Development Scientist

4 weeks ago

Bristol, United Kingdom The Nudge Group Full time

Our client is a leading pharmaceutical company committed to improving global health through the development and commercialization of innovative medications. As part of their portfolio, they aim to enhance the Nurofen range of over-the-counter (OTC) pain relief medications, ensuring effective relief from various types of pain. Dosage forms and formulations to be developed include Tablets and Caplets, Liquid Capsules, Gels and Creams, and Express Tablets.


Position Overview:


We are seeking a highly skilled and motivated Formulation Development Scientist to join our client's Formulation Development team or act as a consultant focused on the Nurofen product line. The successful candidate will play a key role in designing, optimizing, and commercializing formulations for Nurofen pain relief medications, ensuring product quality, efficacy, and regulatory compliance.


Responsibilities:


Formulation Design and Optimization:

  • Develop and optimize formulations for Nurofen pain relief products, considering factors such as efficacy, safety, stability, and manufacturability.
  • Conduct formulation studies to explore novel approaches and ingredients for enhanced pain relief and patient convenience.

Ingredient Selection and Compatibility Assessment:

  • Research and select appropriate active pharmaceutical ingredients (APIs), excipients, and delivery systems for inclusion in Nurofen formulations.
  • Evaluate compatibility and interactions between ingredients to ensure formulation stability and effectiveness.

Dosage Form Development:

  • Determine the optimal dosage form (e.g., Tablets and Caplets, Liquid Capsules, Gels and Creams, Express Tablets) and formulation parameters for each Nurofen product, balancing efficacy, patient compliance, and market preferences.
  • Collaborate with cross-functional teams to develop innovative dosage forms and delivery technologies for improved pain management.

Stability Testing and Shelf-Life Evaluation:

  • Design and execute stability studies to assess the shelf life and degradation kinetics of Nurofen formulations under various storage conditions.
  • Analyze stability data and recommend formulation modifications as needed to ensure product quality and regulatory compliance.

Process Scale-Up and Optimization:

  • Collaborate with manufacturing teams to scale up formulation processes from laboratory to production scale, optimizing efficiency, yield, and cost-effectiveness.
  • Implement process improvements and troubleshooting strategies to address manufacturing challenges and ensure consistent product quality.

Regulatory Compliance and Documentation:

  • Stay informed about relevant regulatory guidelines and requirements for pharmaceutical formulations, ensuring compliance with applicable standards and regulations (e.g., FDA, EMA).
  • Prepare and maintain comprehensive documentation, including formulation records, batch documentation, and regulatory submissions, in accordance with company policies and regulatory requirements.


Experience:

  • Proven experience in pharmaceutical formulation development, preferably in the pain relief or analgesics therapeutic area.
  • Strong knowledge of pharmaceutical dosage forms, drug delivery systems, and formulation principles.
  • Proficiency in experimental design, data analysis, and interpretation.
  • Excellent communication and teamwork skills, with the ability to collaborate effectively across functional teams.
  • Demonstrated ability to manage multiple projects simultaneously and deliver results within established timelines.
  • Familiarity with regulatory requirements for pharmaceutical products, including GMP, ICH guidelines, and regulatory submissions.
  • Commitment to quality, integrity, and continuous improvement in pharmaceutical development practices.


In summary, the Formulation Development Scientist will be responsible for the design, optimization, and commercialization of formulations for Nurofen pain relief medications, ensuring their quality, efficacy, and regulatory compliance. This role is crucial for contributing to the success and reputation of our client's Nurofen range in the market.

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