Current jobs related to Scientist II, Viral Vector Development - London - Orchard Therapeutics

  • Senior Viral Vector Development Specialist

    1 month ago

    London, Greater London, United Kingdom Orchard Therapeutics Full time

    About the RoleOrchard Therapeutics is a global gene therapy leader focused on transforming the life of patients with rare disorders through innovative gene therapies based on gene-modified hematopoietic stem cells (HSC). We are seeking an experienced Scientist II, Viral Vector Development to join our team in London.The successful candidate will support the...

  • Viral Vector Production Team Lead

    1 month ago

    London, Greater London, United Kingdom Orchard Therapeutics Full time

    About the JobAs a Scientist II, Viral Vector Development at Orchard Therapeutics, you will support the Principal Scientist in the development of innovative, high-yield processes for production of lentiviral vectors. You will also compile process data, prepare databases to analyze results, confirm scientific hypotheses, and propose new experiments.Key...

  • Lead Lentiviral Vector Process Developer

    1 month ago

    London, Greater London, United Kingdom Orchard Therapeutics Full time

    About the CompanyOrchard Therapeutics is a global gene therapy company with a diverse and dynamic work environment. Our Technical Development team sits within Technical Operations and is responsible for the development and characterization of Lentiviral Vectors (LVVs) and DS/DP production processes.We require an experienced Scientist II, Viral Vector...

  • Analytical Development Scientist

    3 weeks ago

    London, United Kingdom Next Phase Recruitment Full time

    A pioneering company who are at the centre of the Cell & Gene Therapy sector are seeking a Scientist to join their core R&D group based in Central London.They are recruiting for a Scientist with an expertise in Molecular Biology assays to join theirViral Vector group to enhance their characterisation and analytical capabilities.To accelerate the translation...

  • Viral Vector Production Specialist

    3 weeks ago

    London, Greater London, United Kingdom Orchard Therapeutics Full time

    We are a global gene therapy leader focused on transforming the lives of patients with rare disorders through innovative therapies based on gene-modified hematopoietic stem cells. Our Technical Development team sits within Technical Operations and is responsible for the development and characterization of Lentiviral Vectors (LVVs) and DS/DP production...

  • Viral Vector Development Lead

    1 month ago

    London, Greater London, United Kingdom Orchard Therapeutics Full time

    About the RoleThis is an exciting opportunity to join our global gene therapy leader as a Viral Vector Development Lead. You will lead the development of upstream and downstream processes for LVVs to deliver robust manufacturing platforms for early and late-stage clinical and commercial development.You will be responsible for compiling process data,...

  • Lentiviral Vector Process Developer

    4 weeks ago

    London, Greater London, United Kingdom Orchard Therapeutics Full time

    We are looking for a highly motivated and organized individual to join our Technical Operations team as a Scientist II, Viral Vector Development.In this role, you will support the design, development and improvement of upstream and downstream processes for Lentiviral Vectors (LVVs) to deliver robust manufacturing platforms for early and late-stage clinical...

  • Viral Vector Specialist

    3 weeks ago

    London, Greater London, United Kingdom Royal Free London NHS Foundation Trust Full time

    Role OverviewWe have an exciting opportunity for a skilled Lentiviral Manufacturing Engineer to join our team at the Royal Free London NHS Foundation Trust. This role involves supporting the development and implementation of novel lentiviral manufacturing techniques in suspension cell bioreactors.The successful candidate will work closely with our...

  • Principal Scientist

    1 month ago

    London, Greater London, United Kingdom Orchard Therapeutics Full time

    Join Orchard Therapeutics as a Senior Scientist in our Cell and Gene Therapy team in Hammersmith, London.We are looking for an experienced professional with a strong background in biotechnology, process development, or a related field. The ideal candidate will have a minimum of 5 years of experience in viral vector development, manufacture, and delivery,...

  • Upstream Process Development Scientist

    3 weeks ago

    London, United Kingdom Hyper Recruitment Solutions Ltd Full time

    We are currently looking for a Upstream Process Development Scientist to join a growing Gene Therapy company based in the North London area. As the Upstream Process Development Scientist you will be responsible for developing upstream processes for theproduction of AAV Viral Vectors for the treatment of chronic and rare diseases. This position would suite a...

  • GMP Scientist

    2 weeks ago

    London, Greater London, United Kingdom NHS Full time

    About the PositionWe are looking for a talented GMP Scientist to play a key role in building and qualifying a GMP process from the ground up. This position requires strong experience in viral vector manufacture and scale-up, as well as analytical assays.The ideal candidate will have a strong background in research and development, with experience in cell...

  • Senior Process Development Scientist

    3 weeks ago

    London, Greater London, United Kingdom Orchard Therapeutics Full time

    Job DescriptionWe are seeking a highly skilled Senior Process Development Scientist to join our Technical Development team at Orchard Therapeutics. The successful candidate will be responsible for the development and characterization of Lentiviral Vectors (LVVs) and DS/DP production processes.This is an exciting opportunity for a motivated individual to work...

  • Research Scientist Leader

    1 month ago

    London, Greater London, United Kingdom King's College London Full time

    About King's College LondonThe Gene Therapy Vector Facility at King's is a leading institution in the field of gene therapy, manufacturing viral vectors for various cancers and rare diseases. As a full-time Manufacturing Senior Scientist, you will be part of an indefinite contract with 35 hours of work per week.Required Skills and QualificationsA strong...

  • Lentiviral Vector Production Technician

    4 weeks ago

    London, Greater London, United Kingdom Orchard Therapeutics Full time

    Lentiviral Vector Production Technician Job DescriptionAs a key member of the Translational Research Team at Orchard Therapeutics, the successful candidate will play a crucial role in supporting the production of Lentiviral Vectors. This involves working closely with the team to plan and conduct routine lentiviral production runs, ensuring laboratory...

  • Development Scientist

    1 month ago

    London, United Kingdom Touchlight Full time

    Touchlight is pioneering the Synthetic DNA market. Touchlight is focussed on the enzymatic synthesis of novel DNA formats. Through the Covid pandemic, this quiet revolution has been propelled into the spotlight with the scale-up and proof of concept of RNA and DNA based vaccines. In addition, the stellar growth in viral and non-viral cell and gene therapy...

  • Regulatory Scientist in Cell and Gene Therapy

    3 weeks ago

    London, Greater London, United Kingdom Orchard Therapeutics Full time

    As a Regulatory Scientist in Cell and Gene Therapy, you will play a critical role in ensuring that our products meet the highest standards of quality and regulatory compliance.You will be responsible for providing expert review and approval of executed batch records, test records, and associated documentation for release of LVVs and plasmids used in their...

  • Development Scientist

    1 month ago

    London, United Kingdom Touchlight Full time

    Job Description Touchlight is pioneering the Synthetic DNA market. Touchlight is focussed on the enzymatic synthesis of novel DNA formats. Through the Covid pandemic, this quiet revolution has been propelled into the spotlight with the scale-up and proof of concept of RNA and DNA based vaccines. In addition, the stellar growth in viral and non-viral cell...

  • Development Scientist

    2 months ago

    London,, UK, United Kingdom Touchlight Full time

    Touchlight is pioneering the Synthetic DNA market.Touchlight is focussed on the enzymatic synthesis of novel DNA formats. Through the Covid pandemic, this quiet revolution has been propelled into the spotlight with the scale-up and proof of concept of RNA and DNA based vaccines. In addition, the stellar growth in viral and non-viral cell and gene therapy...

  • Development Scientist

    2 months ago

    London, United Kingdom Touchlight Full time

    Touchlight is pioneering the Synthetic DNA market.Touchlight is focussed on the enzymatic synthesis of novel DNA formats. Through the Covid pandemic, this quiet revolution has been propelled into the spotlight with the scale-up and proof of concept of RNA and DNA based vaccines. In addition, the stellar growth in viral and non-viral cell and gene therapy...

  • Development Scientist

    1 month ago

    London, United Kingdom Touchlight Full time

    Touchlight is pioneering the Synthetic DNA market.Touchlight is focussed on the enzymatic synthesis of novel DNA formats. Through the Covid pandemic, this quiet revolution has been propelled into the spotlight with the scale-up and proof of concept of RNA and DNA based vaccines. In addition, the stellar growth in viral and non-viral cell and gene therapy...

Scientist II, Viral Vector Development

1 month ago

London, United Kingdom Orchard Therapeutics Full time

Contract: 10-month fixed-term contract

Location: London (Hammersmith)

Reporting to: Director, Viral Vector Development

Orchard Therapeutics, a Kyowa Kirin company, is a global gene therapy leader focused on transforming the life of patients with rare disorders through innovative gene therapies based on gene-modified hematopoietic stem cells (HSC). Orchard has its global headquarters in London and U.S. headquarters in Boston.

Technical Development sits within Technical Operations at Orchard and is responsible for the development and characterization of Lentiviral Vectors (LVVs) and DS/DP production processes, which meet patient demand for therapeutic products of the best quality.

Reporting to the Director, Viral Vector Development, the Scientist II, Viral Vector Development, will support the Principal Scientist in the development of innovative, high-yield processes for production of lentiviral vectors to support early, and late-stage clinical studies. This role is based in our Hammersmith, London facilities within our global headquarters and will suit candidates who would like to join a global cell and gene therapy company with a diverse and dynamic work environment.

Key Elements and Responsibilities

· Support the design, development and improvement of upstream and downstream processes for LVVs to deliver robust manufacturing platforms for early and late-stage clinical and commercial development

· Compile process data, prepare databases to analyse results, confirm scientific hypotheses and/or propose new experiments

· Prepare, review and complete study reports and protocols/SOPs

· Assist with CMC and regulatory submissions

· Contribute to routine lab maintenance

· Communicate, share and discuss work progress internally and where appropriate with external partners

· Regularly exchange with external partners and CDMOs on process development and manufacturing activities to support ongoing projects.

Experience & Knowledge

· Experience in biotechnology or pharmaceutical industry with a primary focus on the process development and manufacturing of viral vectors, preferably retro and lentiviral vectors

· Experience in cell line culture techniques and handling of adherent and suspension cell lines in different culture systems, with demonstrated skills in aseptic techniques

· Knowledge in bioprocessing, purification of viral vectors and virology

· Use of more specialist lab equipment e.g. bioreactors, AKTA or TFF systems is ideal

· Proficiency with MS office, MFCS, SnapGene, Unicorn, electronic lab-books and/or other commonly used software

Skills & Abilities

· Ability to operate in a fast paced, multidisciplinary environment

· Ability to document and maintain record of lab work, raw data and results

· Strong organization and planning skills

· Good communication and written skills for report-writing, team communications and presentations

· Able to independently design and execute experiments following laboratory procedures, appropriately analyse data and provide an interpretation of results

· Creativeness, motivation, and troubleshooting skills to solve problems and/or develop new technical capabilities

Education

· A minimum MSc or equivalent in a relevant scientific discipline: bioprocessing, cell and gene therapy, biological sciences, biotechnology etc, combined with at least one year of industrial experience.

#J-18808-Ljbffr