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Senior Postdoctoral Genomics Scientist
3 months ago
The Oxford Biomedical Research Centre (BRC) Genomic Medicine Theme is looking for a Senior Postdoctoral Scientist in Genomics to join their team at the University of Oxford's Centre for Human Genetics (WHG), within Professor Jenny Taylor's group.
The Centre for Human Genetics has an outstanding history of genetics research and gene discovery in rare and common diseases whilst the Oxford BRC's Genomic Medicine Theme has an impressive track record of translating novel genomics tests and technologies into the clinic to inform diagnosis and treatment of patients.
As the Senior Postdoctoral Genomics Scientist, you will be responsible for conducting analysis of whole genome sequencing data from rare disease patient samples leading to comprehensive identification of candidate disease-causing variants, including single nucleotide, structural, splicing and non-coding variants and undertaking analysis of rare disease cases in the Genomics England (GEL) national 100,000 Genomes Project. You may also have experience of UK Biobank data enabling translation of results between rare and common diseases. You will also apply novel bioinformatics pipelines, algorithms and tools including publicly available or commercial software packages for genome sequence analysis, and utilise multi-omics datasets. Meeting with the other members of the BRC Genomic Medicine Theme to design studies and review results, liaising with other bioinformaticians in CHG and be aware of relevant complementary projects in other Oxford centres including the Big Data Institute, Weatherall Institute for Molecular Medicine and Centre for Medicines Discovery to support variant annotation and interpretation will be also among your responsibilities.
To be successful in this role, you will hold a PhD in Genetics or related subject along with strong postdoctoral experience in analysis and interpretation of genome sequencing data to include single nucleotide and structural variants, copy number abnormalities as well as assessment of variants in regulatory or non-coding regions. Experience of identifying pathogenic variants underpinning rare disease pathogenesis from genome sequencing data and in analysis of multi-omics datasets is also required. You will have sufficient knowledge of genetic variant databases such as Decipher, ClinVar, Clingen, gnomAD and disease-specific databases to inform variant annotation, together with excellent communication skills (both written and oral) and the ability to communicate effectively at all levels (of technical knowledge).
Applications for this vacancy are to be made online, click on the Apply button above to upload a supporting statement and CV as part of your online application. Your supporting statement must explain how you meet each of the selection criteria for the post using examples of your skills and experience.
This position is offered full time on a fixed term contract until 30 November 2027 and is funded by the NIHR.
Only applications received before 12 midday on Thursday 11 July 2024 will be considered. Interviews to be held in the week commencing 22 July 2024. Please quote 173349 on all correspondence.
£45,585 to £54,395 per annum with a discretionary range to £59,421 per annum
