Microfluidic HDX Research Fellow

2 months ago


Southampton, Southampton, United Kingdom UNIVERSITY OF SOUTHAMPTON Full time

Research Fellow in Microfluidic Hydrogen-Deuterium Exchange Mass Spectrometry

Development of ultra-fast microfluidic processors for investigating protein dynamics

Life Sciences Building, University of Southampton

The Biomedical Microfluidics group (West) and Mass Spectrometry groups (Reading) are based in the Life Sciences Building in Southampton and have a strong track record of developing new methods for biological discovery. The labs have a keen interest in extending the state of the art for time-resolved protein bioscience.

An exciting opportunity now presents itself for a postdoctoral Research Fellow to use existing microfluidic devices and developing next generation microfluidic devices for protein hydrogen-deuterium exchange mass spectrometry (HDX-MS). These devices will greatly improve the temporal resolution to provide a new means to study protein plasticity and conformational dynamics. This cutting-edge interdisciplinary project is a collaboration between the West and Reading labs and will position the post-holder at the forefront of HDX-MS and microfluidic fields.

The post-holder will possess expertise in one or more of analytical chemistry, mass spectrometry and HDX-MS, NMR and microfluidics. As required, time will be dedicated to learning new techniques to deliver the research. These techniques will be used to develop and test-drive a fast HDX-MS technology to gain new insights into protein dynamics.

You will be motivated, educated to PhD* level in a relevant subject area, ideally have practical laboratory experience of mass spectrometry or microfluidics and be prepared to travel to Exeter and Toronto (1 week each) at the end of the project to share the technology with collaborators.

*Soon to graduate PhD candidates are encouraged to apply too.

The position is full-time and for 12 months in the first instance. The start date is flexible but the successful candidate is expected to be in post by 1st December 2024 at the latest. For an informal discussion or to arrange a visit please contact Dr Jonathan West ).

Applications for Research Fellow positions will be considered from candidates who are working towards or nearing completion of a relevant PhD qualification. The title of Research Fellow will be applied upon successful completion of the PhD. Prior to the qualification being awarded the title of Senior Research Assistant will be given.



  • Southampton, Southampton, United Kingdom University of Southampton Full time

    Full Time Fixed Term for 12 monthsThe Biomedical Microfluidics group (West) and Mass Spectrometry groups (Reading) are based in the Life Sciences Building in Southampton and have a strong track record of developing new methods for biological discovery. The labs have a keen interest in extending the state of the art for time-resolved protein bioscience. An...


  • Southampton, Southampton, United Kingdom University of Southampton Full time

    Full Time Fixed Term for 36 monthsWe wish to appoint a Research Fellow or Senior Research Fellow to support research into sudden and unexpected deaths in infancy and childhood. This project, called QUINTET, is the first of its kind, and has national reach involving multiple stakeholders. Families often do not have ready access to support and care after the...

  • Research Fellow

    3 weeks ago


    Southampton, Southampton, United Kingdom UNIVERSITY OF SOUTHAMPTON Full time

    We wish to appoint a Research Fellow or Senior Research Fellow to support research into sudden and unexpected deaths in infancy and childhood. This project, called QUINTET, is the first of its kind, and has national reach involving multiple stakeholders. Families often do not have ready access to support and care after the sudden death of their child, and...

  • Research Fellow

    1 month ago


    Southampton, Southampton, United Kingdom University of Southampton Full time

    ESRC Project: Powering Up Coastal Economies: Path Creation in Low Carbon and Renewable EnergiesApplications are invited for a full-time Research Fellows position on the above research project which is being led by Professor Peter Sunley, in the Department of Geography and Environmental Science, University of Southampton. The post will work closely with the...

  • Research Fellow

    4 weeks ago


    Southampton, Southampton, United Kingdom University of Southampton Full time

    Location: Highfield Campus Fixed Term: 2 YearsResearch Fellow – Advanced Beam Shaping for Fibre LasersFibre & Systems GroupOptoelectronics Research CentreA Research Fellow position is available for a highly motivated and talented researcher with a strong interest in optical fibre technology to work on the UK's Engineering and Physical Sciences Research...

  • Research Fellow

    2 months ago


    Southampton, Southampton, United Kingdom University of Southampton Full time

    Optoelectronics Research CentreFull Time Fixed Term (until 31/07/2026)Interview Date: To be confirmedA Research Fellow position is available for a highly motivated and talented researcher with a strong interest in optical fibre technology to work on the UK's Engineering and Physical Sciences Research Council (EPSRC) funded Programme Grant, HiPPo (Smart Fibre...

  • Research Fellow

    2 months ago


    Southampton, Southampton, United Kingdom University of Southampton Full time

    OverviewThe PressueLab within the Skin Sensing Research Group (SSRG) is offering a unique opportunity to deliver research activities as part of a Transforming Community Health grant co-funded by the UKRI' s Engineering and Physical Sciences Research Council (EPSRC) and the National Institute for Health Research (NIHR). The SEAMLSS project will involve...

  • Research Fellow

    1 month ago


    Southampton, Southampton, United Kingdom University of Southampton Full time

    We wish to appoint a Research Fellow to support research into outcomes for Adolescents and Young Adults (AYA) with cancer. This is a very exciting international project, called STRONG-AYA, focused on improving the lives of young people with cancer. AYAs with cancer form a unique group; they face age-specific issues (e.g. infertility, unemployment, financial...

  • Research Fellow

    2 months ago


    Southampton, Southampton, United Kingdom University of Southampton Full time

    CO-ACTION Programme Grant: Personalised social and self-management support for better living with multiple long-term conditions in the community.An exciting opportunity has arisen for a Research Fellow to work on a NIHR ARC Wessex adopted and NIHR PGfAR funded programme grant: Personalised social and self-management support for better living with multiple...

  • Senior Research Fellow

    2 months ago


    Southampton, Southampton, United Kingdom UNIVERSITY OF SOUTHAMPTON Full time

    Primary Ciliary Dyskinesia (PCD) GroupSenior Research Fellow in Genomic InformaticsThe PCD Research Group at the University of Southampton School of Clinical and Experimental Sciences, Faculty of Medicine is based within University Hospital Southampton NHS Foundation Trust (UHS). We are one of three national centres providing multidisciplinary...

  • Senior Research Fellow

    2 months ago


    Southampton, Southampton, United Kingdom University of Southampton Full time

    The PCD Research Group at the University of Southampton School of Clinical and Experimental Sciences, Faculty of Medicine is based within University Hospital Southampton NHS Foundation Trust (UHS). We are one of three national centres providing multidisciplinary diagnostic-management services for referred patients, supported by state-of-the-art diagnostic...


  • Southampton, Southampton, United Kingdom UNIVERSITY OF SOUTHAMPTON Full time

    We are looking for a highly motivated Research Fellow to work on novel wireless communication systems with focus on not-terrestrial networks.Be a part of the University of Southampton, an institution in the top one per cent of world universities and one of the UK's Russell group research-intensive universities. We have an international reputation for...


  • Southampton, Southampton, United Kingdom University of Southampton Full time

    Full Time Fixed Term until 31/03/2025Interview Date: To be confirmedWe are looking for a highly motivated Research Fellow to work on novel wireless communication systems with focus on not-terrestrial networks.Be a part of the University of Southampton, an institution in the top one per cent of world universities and one of the UK's Russell group...


  • Southampton, Southampton, United Kingdom UNIVERSITY OF SOUTHAMPTON Full time

    Applications are invited from researchers to work as a Post-Doctoral Research Fellow in the University of Southampton's world-leading Geochemistry Research Group ). In the School of Ocean and Earth Science at the National Oceanography Centre Southampton you will join a community of >500 researchers and support staff drawn from physics, chemistry, biology,...


  • Southampton, Southampton, United Kingdom UNIVERSITY OF SOUTHAMPTON Full time

    OverviewThe PressueLab within the Skin Sensing Research Group (SSRG) is offering a unique opportunity to deliver research activities as part of a Transforming Community Health grant co-funded by the UKRI' s Engineering and Physical Sciences Research Council (EPSRC) and the National Institute for Health Research (NIHR). The SEAMLSS project will involve...


  • Southampton, Southampton, United Kingdom UNIVERSITY OF SOUTHAMPTON Full time

    Silica Fibre Fabrication GroupOptoelectronics Research CentreA Research Fellow position is available for a highly motivated and talented researcher with a strong interest in optical fibre technology to work on the UK's Engineering and Physical Sciences Research Council (EPSRC) funded Programme Grant, HiPPo (Smart Fibre optic High-power Photonics), and will...


  • Southampton, Southampton, United Kingdom UNIVERSITY OF SOUTHAMPTON Full time

    We wish to appoint a Research Fellow to support research into outcomes for Adolescents and Young Adults (AYA) with cancer. This is a very exciting international project, called STRONG-AYA, focused on improving the lives of young people with cancer. AYAs with cancer form a unique group; they face age-specific issues (e.g. infertility, unemployment, financial...


  • Southampton, Southampton, United Kingdom University of Southampton Full time

    Full Time Fixed Term for 25 monthsInterview Date: To be confirmedDefining the mechanisms of mechano-integration in the growing limb Life Sciences building, University of SouthamptonThe Wann group is based in the Life Sciences Building in Southampton with strong local links within Southampton biological sciences cell biology communities, and, through IFLS,...


  • Southampton, Southampton, United Kingdom UNIVERSITY OF SOUTHAMPTON Full time

    Defining the mechanisms of mechano-integration in the growing limbLife Sciences building, University of SouthamptonThe Wann group is based in the Life Sciences Building in Southampton with strong local links within Southampton biological sciences cell biology communities, and, through IFLS, the faculties of Medicine and Engineering. The lab has a central...


  • Southampton, Southampton, United Kingdom UNIVERSITY OF SOUTHAMPTON Full time

    CO-ACTION Programme Grant: Personalised social and self-management support for better living with multiple long-term conditions in the community.An exciting opportunity has arisen for a Research Fellow to work on a NIHR ARC Wessex adopted and NIHR PGfAR funded programme grant: Personalised social and self-management support for better living with multiple...