Postdoctoral Research Associate

1 month ago

London, Greater London, United Kingdom King's College London Full time

About Us

The laboratory of Dr. Rushad Pavri at King's College London is inviting applications for a postdoctoral position for a project focused on understanding the molecular mechanisms of antibody somatic hypermutation and its impact on autoimmune disease.

The Pavri group has a long-standing interest and expertise in the molecular mechanisms of antibody maturation and associated genome instability in B lymphocytes. Specifically, we investigate how transcription, chromatin architecture, DNA replication and epigenetic features regulate the key processes of antibody somatic hypermutation and class switch recombination as well as the oncogenic chromosomal translocations arising from these mutagenic pathways. In addition, we study the physiology of germinal centers in murine lymphoid tissues, which is where the antibody maturation reactions occur. The laboratory uses a multi-disciplinary approach including mouse genetics, immunological assays, genetic screening and various genomics tools. A list lab projects and publications from the group can be found here:

About the role

The project in question involves the functional characterisation of newly identified factors regulating somatic hypermutation and germinal center physiology. The candidate should have a PhD (or pending PhD results) in a relevant area of biological or biomedical sciences. They will be expected to design and conduct experiments independently, have excellent written and verbal communication skills, be highly collaborative, co-supervise students and contribute to laboratory management.

The project involves extensive mouse work, tissue culture, molecular biology and genomics, hence experience in these areas is highly desirable. Knowledge of immunology, gene regulation and flow cytometry will be an advantage.

This is a full-time post (35 Hours per week), and you will be offered a fixed term contract until 30 November 2027.

About you

To be successful in this role, we are looking for candidates to have the following skills and experience:

Essential criteria

  • PhD in biological or biomedical science.*
  • Strong publication record, as demonstrated by first author publication(s) in peer reviewed journals (preprints will also be considered)
  • Experience and comfort in working with mice
  • Experience in molecular biology (eg. cloning) and tissue culture
  • Some knowledge of methods in biochemistry (eg. protein analyses), immunology (flow cytometry) and gene regulation
  • Ability to independently design and conduct experiments, analyse data, and present results professionally in written and verbal form
  • Strong collaborative nature and willingness to help with mentoring students
  • A high level of self-motivation and ability to work flexible hours and meet deadlines

* Please note that this is a PhD level role but candidates who have submitted their thesis and are awaiting award of their PhDs will be considered. In these circumstances the appointment will be made at Grade 5, spine point 30 with the title of Research Assistant. Upon confirmation of the award of the PhD, the job title will become Research Associate and the salary will increase to Grade 6.

Desirable criteria

  • Knowledge of gene regulation, B cell biology and antibody diversification
  • Experience with genomics and next-generation sequencing
  • Basic bioinformatics skills

Closing date: 7 August 2024

£43,205 per annum, including London Weighting Allowance.

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