PhD Studentship: EPSRC Supported EngD Project. Development and Modelling of Process Control for Scale Up and Optimisation of Pharmaceutical High Shear Wet Granulation

4 weeks ago


Birmingham, Birmingham, United Kingdom University of Birmingham Full time

Tablet manufacture is a fundamental process essential for delivering most existing and new drugs to the patient. High shear wet granulation can be a key component of tabletting lines, performing the twin functions of mixing and size enlargement. Mixing ensures uniformity of drug distribution while size enlargement improves powder flowability; both help maintain uniformity of tablet drug loading. Granule properties (size, hardness, porosity etc) further influence the operation of the tablet press (compaction speed and pressure) to deliver the desired tablet properties (strength and dissolution, for example). The translation of input material properties into tablet properties via granulation, granule properties and tablet compaction, lacks fundamental understanding. Prior knowledge developed on current products through empirical work underpins the process design of most commercial batch granulation processes. This consumes many batch runs, plant time and input materials for new drugs and new process lines but also for existing drugs on existing lines with the need for lifecycle changes. The consequence is wasted time and wasted material with significant cost and environmental implications.

Supervisor(s): Dr C. Windows-Yule and Dr A. Ingram.

Funding notes:

To be eligible for EPSRC funding candidates must have at least a 2(1) in an Engineering or Scientific discipline or a 2(2) plus MSc. Currently we are only able to accept UK nationals. For details on the Engineering Doctorate scheme visit the homepage:

Deadline: 31 May 2024

To apply please email your cv via the above 'Apply' button.

EPSRC funding



  • Birmingham, Birmingham, United Kingdom University of Birmingham Full time

    Johnson Matthey [JM] makes formulated products, catalysing the net zero transition. These are heavily characterised and tested during product development and manufacturing. The move towards better process efficiency, product control and increasing digitisation of manufacturing plant leads inexorably to a need for improved on-line measurement, and real time...


  • Birmingham, Birmingham, United Kingdom University of Birmingham Full time

    ARCANE is a collaborative research project across three leading UK universities and Rolls-Royce plc. The project aims to develop the state-of-the-art scientific understanding of nucleation defect formation within directionally solidified single crystal (SX) castings, and their role in the reduction in mechanical performance, through novel experimental...


  • Birmingham, Birmingham, United Kingdom University of Birmingham Full time

    ARCANE is a collaborative research project across three leading UK universities and Rolls-Royce plc. The project aims to develop the state-of-the-art scientific understanding of nucleation defect formation within directionally solidified single crystal (SX) castings, and their role in the reduction in mechanical performance, through novel experimental...


  • Birmingham, Birmingham, United Kingdom University of Birmingham Full time

    Wet wipes, coming in different shapes and forms such as baby wipes, wet towels, antibacterial hand wipes, medical textiles, are essential to our daily life as a practical hygiene and cleaning product. Global market for wet wipes was around 15.2 Billion USD in 2022, and is projected to reach 33.8 Billion USD by 2030. The sector has transitioned from using...


  • Birmingham, Birmingham, United Kingdom University of Birmingham Full time

    Hair conditioning is an essential process to our daily life, whereby a layer of formulated product is deposited on hair surface, resulting in desirable benefits. Its global market was ~ 9.14 Billion USD in 2021, and has a significant impact on not only the wellbeing of human, but the environment. The chemical compounds deposited on hair fibres include fatty...


  • Birmingham, Birmingham, United Kingdom University of Birmingham Full time

    ARCANE is a collaborative research project across three leading UK universities and Rolls-Royce plc. The project aims to develop the state-of-the-art scientific understanding of nucleation defect formation within directionally solidified single crystal (SX) castings, and their role in the reduction in mechanical performance, through novel experimental...


  • Birmingham, Birmingham, United Kingdom University of Birmingham Full time

    Effective, efficient, and residue-free washing has long been a result sought by users of automatic dishwashers. Understanding the processes and mechanisms involved in the wash phases of an automatic dishwashing cycle, which lead to the formation of spots and thin film on dishware, is important to enable the development of superior automatic dishwashing...


  • Birmingham, Birmingham, United Kingdom University of Birmingham Full time

    As the largest organ of human being, skin acts as a barrier to the external environment, and accommodates a diverse microbiota comprised of bacteria, fungi, viruses, and microeukaryotes. Most of such skin microbes are harmless or commensal organisms that play essential roles in inhibiting colonization by pathogenic microbes or modulating innate and adaptive...


  • Birmingham, Birmingham, United Kingdom University of Birmingham Full time

    Effective, residue free washing has long been a result sought by automatic dishwasher users. Understanding the different processes and mechanisms in the wash phases of an automatic dishwashing cycle, which lead to the formation of spots and filming on dishware is important to enable the development of superior automatic dishwashing products and ensure...


  • Birmingham, Birmingham, United Kingdom University of Birmingham Full time

    ARCANE is a collaborative research project across three leading UK universities and Rolls-Royce plc. The project aims to develop the state-of-the-art scientific understanding of nucleation defect formation within directionally solidified single crystal (SX) castings, and their role in the reduction in mechanical performance, through novel experimental...


  • Birmingham, Birmingham, United Kingdom University of Birmingham Full time

    ARCANE is a collaborative research project across three leading UK universities and Rolls-Royce plc. The project aims to develop the state-of-the-art scientific understanding of nucleation defect formation within directionally solidified single crystal (SX) castings, and their role in the reduction in mechanical performance, through novel experimental...


  • Birmingham, Birmingham, United Kingdom University of Birmingham Full time

    In a world facing climate crisis, it is vital to develop new ways to mitigate climate change. This project, funded by Origen Carbon Solutions, focuses on the modelling and optimisation of innovative Carbon Capture and Storage (CCS) and Direct Air Capture (DAC) technologies. DAC is a developing technology for removing CO2 from the atmosphere where the CO2...


  • Birmingham, Birmingham, United Kingdom University of Birmingham Full time

    ARCANE is a collaborative research project across three leading UK universities and Rolls-Royce plc. The project aims to develop the state-of-the-art scientific understanding of nucleation defect formation within directionally solidified single crystal (SX) castings, and their role in the reduction in mechanical performance, through novel experimental...


  • Birmingham, Birmingham, United Kingdom University of Birmingham Full time

    Bubble-particle systems are encountered in a wide range of industrial and environmental applications (flotation, bioreactors, slurry bubble columns) but the complex dynamics and interactions make the design and operation of such systems particularly challenging. This collaborative project between the University of Birmingham and McGill University (Montreal,...


  • Birmingham, Birmingham, United Kingdom University of Birmingham Full time

    PhD Birmingham UK Students Not Specified Full Time 22nd April 2024 22nd July 2024Bubble-particle systems are encountered in a wide range of industrial and environmental applications (flotation, bioreactors, slurry bubble columns) but the complex dynamics and interactions make the design and operation of such systems particularly challenging. This...


  • Birmingham, Birmingham, United Kingdom University of Birmingham Full time

    ARCANE is a collaborative research project across three leading UK universities and Rolls-Royce plc. The project aims to develop the state-of-the-art scientific understanding of nucleation defect formation within directionally solidified single crystal (SX) castings, and their role in the reduction in mechanical performance, through novel experimental...


  • Birmingham, Birmingham, United Kingdom University of Birmingham Full time

    ARCANE is a collaborative research project across three leading UK universities and Rolls-Royce plc. The project aims to develop the state-of-the-art scientific understanding of nucleation defect formation within directionally solidified single crystal (SX) castings, and their role in the reduction in mechanical performance, through novel experimental...


  • Birmingham, Birmingham, United Kingdom University of Birmingham Full time

    The influence of plastic pollution on our environment has been well documented, however, there remains a knowledge gap between relating to how new polymers and plastics might biodegrade. To this end, we have a fully funded PhD studentship (due to eligibility criteria, only for UK applicants) that will focus on developing sustainable polymer platforms,...


  • Birmingham, Birmingham, United Kingdom University of Birmingham Full time

    A PhD Studentship is available for a suitably qualified candidate to conduct research leading to the award of a PhD degree in the fields of Chemical and Biomedical Engineering. The successful candidate will join the world-leading Advanced Nano Materials, Structures and Applications (ANMSA) Group, one of the leading academic groups in the field of development...


  • Birmingham, Birmingham, United Kingdom University of Birmingham Full time

    We aim to develop a new data-driven tool to unravel context-dependency and enhance resilience-based management of transport infrastructure assets, by integrating computational modelling and AI. The primary objective of this PhD program is to enhance advanced Finite Element (FE) models by incorporating data sourced from diverse outlets like digital twins,...