Current jobs related to PhD Studentship: Choroid Plexus Pathology in Multiple Sclerosis and Alzheimer's Disease: Does Thyroid Hormone Transport Failure Drive Chronic Inflammation and Neurodegeneration? - Plymouth, Plymouth - University of Plymouth
-
Clinical Nurse Specialist
1 month ago
Plymouth, Plymouth, United Kingdom Stoke Surgery Full timePosition Overview We are seeking a skilled Clinical Nurse Specialist to join our dedicated team at Stoke Surgery, working on a part-time basis of 2-3 days per week under a Permanent Contract. This role is integral to our Primary Healthcare Nursing team, focusing on the provision of safe and effective nursing care to our diverse patient population. Key...
-
General Practitioner Position
1 month ago
Plymouth, Plymouth, United Kingdom Fuller and Forbes Partnership Full timeJob Overview The Fuller and Forbes Partnership is currently seeking to recruit dedicated General Practitioners for up to 13 sessions of GP time. We welcome applications for both full-time and part-time positions. The successful candidates will be expected to provide services across multiple locations, ensuring a traditional and efficient model of...
-
Practice Nurse
3 weeks ago
Plymouth, Plymouth, United Kingdom Stoke Surgery Full timeAbout Stoke SurgeryWe are a dynamic and forward-thinking healthcare organization dedicated to providing exceptional patient care and services. Our team of healthcare professionals is committed to delivering high-quality, patient-centered care in a supportive and inclusive environment.Job SummaryWe are seeking an experienced and skilled Practice Nurse to join...
-
Biomedical Scientist
2 weeks ago
Plymouth, Plymouth, United Kingdom Transformation Unit Full timeJob Title: Biomedical Scientist - Immunology SpecialistJob Type: Full-timeJob Category: HealthcareCompany: Transformation UnitJob SummaryWe are seeking a highly skilled Biomedical Scientist to join our team as an Immunology Specialist. The successful candidate will be responsible for processing biological samples, performing complex analytical techniques,...
-
Biomedical Scientist
2 weeks ago
Plymouth, Plymouth, United Kingdom Transformation Unit Full timeJob Title: Biomedical Scientist - Immunology SpecialistJob Type: Full-timeJob Category: HealthcareCompany: Transformation UnitJob SummaryWe are seeking a highly skilled Biomedical Scientist to join our team as an Immunology Specialist. The successful candidate will be responsible for processing biological samples, performing complex analytical techniques,...
-
Consultant Neurologist with MS Expertise
3 weeks ago
Plymouth, Plymouth, United Kingdom University Hospitals Plymouth NHS Trust Full timeAbout the RoleWe are seeking a highly skilled Consultant Neurologist with a strong interest in Multiple Sclerosis to join our team at University Hospitals Plymouth NHS Trust.Key ResponsibilitiesProvide high-quality patient care in general neurology outpatient clinics and ward settings.Develop and maintain expertise in Multiple Sclerosis, contributing to the...
-
Consultant Neurologist with MS Expertise
3 weeks ago
Plymouth, Plymouth, United Kingdom University Hospitals Plymouth NHS Trust Full timeAbout the RoleWe are seeking a highly skilled Consultant Neurologist with a strong interest in Multiple Sclerosis to join our team at University Hospitals Plymouth NHS Trust.Key ResponsibilitiesProvide high-quality patient care in general neurology outpatient clinics and ward settings.Develop and maintain expertise in Multiple Sclerosis, contributing to the...
-
HGV Transport Operator
1 month ago
Plymouth, Plymouth, United Kingdom Brackenberry Full timeJob Title: HGV Transport OperatorCompany: Brackenberry LtdBrackenberry Ltd is seeking a dedicated HGV Transport Operator to join our team. This role involves driving various heavy goods vehicles to support waste management and transportation services, contributing to the sustainability of our community. The position is crucial for maintaining the efficiency...
-
Commercial / Cost Accountant
2 weeks ago
Plymouth, Plymouth, United Kingdom What's On In Plymouth Full timeA well-established company, such as What's On In Plymouth, is seeking multiple Cost Controllers to join their growing team within their Defence or Infrastructure projects. This role is available on a hybrid working basis, with a likely 2-3 days in the office.The RoleAs a Cost Controller, you will be responsible for maintaining and delivering timely and...
-
Mechanical Engineer Nights
2 weeks ago
Plymouth, Plymouth, United Kingdom Mars, Incorporated and its Affiliates Full timeJob SummaryWe are seeking a skilled Mechanical Engineer Nights to join our team at Mars, Incorporated and its Affiliates. As a Mechanical Engineer Nights, you will be responsible for maintaining the optimal condition of our manufacturing equipment, ensuring seamless production operations.Key ResponsibilitiesPerform routine maintenance and repairs on...
-
Senior General Practitioner
5 days ago
Plymouth, Plymouth, United Kingdom Beacon Medical Group, Devon Full timeWe are seeking a highly skilled and dedicated Senior General Practitioner to join our resilient GP team at Beacon Medical Group, Devon. Our practice is a Single Practice Primary Care Network covering Ivybridge and Plympton, providing care for 43,000 patients in two defined clinical hubs.We have a unique approach to addressing GP workload, utilizing the PCN...
-
Senior General Practitioner
5 days ago
Plymouth, Plymouth, United Kingdom Beacon Medical Group, Devon Full timeWe are seeking a highly skilled and dedicated Senior General Practitioner to join our resilient GP team at Beacon Medical Group, Devon. Our practice is a Single Practice Primary Care Network covering Ivybridge and Plympton, providing care for 43,000 patients in two defined clinical hubs.We have a unique approach to addressing GP workload, utilizing the PCN...
-
Healthcare Engagement Coordinator
1 month ago
Plymouth, Plymouth, United Kingdom Fuller and Forbes Partnership Full timePosition Overview We are seeking a part-time Healthcare Engagement Coordinator, with a commitment of up to 28 hours per week. The Healthcare Engagement Coordinator plays a vital role in crafting and executing initiatives aimed at improving patient involvement and overall experience. This position emphasizes the importance of patient participation in their...
-
Respiratory Medicine Specialist
2 weeks ago
Plymouth, Plymouth, United Kingdom University Hospitals Plymouth NHS Trust Full timeAbout the RoleWe are seeking a highly skilled and experienced Respiratory Medicine Specialist to join our dynamic team at University Hospitals Plymouth NHS Trust. As a Consultant in Respiratory Medicine, you will play a key role in delivering high-quality patient care and contributing to the development of our respiratory services.Main...
-
Respiratory Medicine Specialist
2 weeks ago
Plymouth, Plymouth, United Kingdom University Hospitals Plymouth NHS Trust Full timeAbout the RoleWe are seeking a highly skilled and experienced Respiratory Medicine Specialist to join our dynamic team at University Hospitals Plymouth NHS Trust. As a Consultant in Respiratory Medicine, you will play a key role in delivering high-quality patient care and contributing to the development of our respiratory services.Main...
-
Biomedical Scientist
2 weeks ago
Plymouth, Plymouth, United Kingdom Transformation Unit Full timeJob OverviewThis is a fixed-term role to cover maternity leave, providing an opportunity to work as a Specialist Biomedical Scientist in our Immunology department.The successful candidate will possess a specialist diploma from the Institute of Biomedical Science and have experience in processing biological samples, including blood, urine, faeces, cerebral...
-
First Contact Physiotherapist
3 weeks ago
Plymouth, Plymouth, United Kingdom Fuller and Forbes Partnership Full timeAbout the RoleWe are seeking a highly skilled and experienced First Contact Physiotherapist to join our team at Fuller and Forbes Partnership. As a key member of our multidisciplinary team, you will play a vital role in providing high-quality patient care and contributing to the development of our primary care services.Key ResponsibilitiesProvide clinical...
-
First Contact Physiotherapist
2 weeks ago
Plymouth, Plymouth, United Kingdom Fuller and Forbes Partnership Full timeAbout the RoleWe are seeking a highly skilled and experienced Physiotherapist to join our team at Fuller and Forbes Partnership. As a First Contact Physiotherapist, you will play a vital role in providing high-quality patient care and contributing to the success of our organization.Key ResponsibilitiesProvide clinical expertise as a first-contact...
-
First Contact Physiotherapist
2 weeks ago
Plymouth, Plymouth, United Kingdom Fuller and Forbes Partnership Full timeAbout the RoleWe are seeking a highly skilled and experienced Physiotherapist to join our team at Fuller and Forbes Partnership. As a First Contact Physiotherapist, you will play a vital role in providing high-quality patient care and contributing to the success of our organization.Key ResponsibilitiesProvide clinical expertise as a first-contact...
-
Physiotherapist for Patient Care
1 week ago
Plymouth, Plymouth, United Kingdom Fuller and Forbes Partnership Full timeAbout the RoleWe are seeking a highly skilled and experienced Physiotherapist to join our team at Fuller and Forbes Partnership. As a First Contact Physiotherapist, you will play a vital role in providing high-quality patient care and contributing to the development of our primary care services.Key ResponsibilitiesProvide clinical expertise as a...
PhD Studentship: Choroid Plexus Pathology in Multiple Sclerosis and Alzheimer's Disease: Does Thyroid Hormone Transport Failure Drive Chronic Inflammation and Neurodegeneration?
4 months ago
DoS: Dr. Eve Kelland )
2nd Supervisor: Dr. Richard Hosking )
3rd Supervisor: Dr. Holly Stephenson )
4th Supervisor: Dr. David Hilton )
Applications are invited for a three-year PhD studentship. The studentship will start on 1st October 2024 or 1st January 2025.
Project Description
Disability and dementia define the devastating diseases Multiple Sclerosis (MS) and Alzheimer's Disease (AD), but what drives the neuroinflammation and neurodegeneration? New research is focusing on the choroid plexus (ChP), a highly vascular structure hidden deep in the brain's fluid-filled cavities. ChP is emerging as a major interface between the peripheral immune and central nervous system, an area of increasing importance in MS and AD. However, ChP also transports thyroid hormone (TH) into cerebrospinal fluid (CSF) which is then distributed throughout the brain.
TH is vital for neurophysiology and immunometabolism such as neurogenesis, growth factors, myelination, synapse formation, microglial activation and phagocytosis. Moreover, work shows ChP is inflamed in MS and AD where it may be vulnerable to pathogens including SARS-CoV-2.
This PhD will help determine if MS and AD ChP pathology leads to altered TH transport that then causes chronic inflammation and neurodegeneration in MS and AD. The student will use cutting-edge facilities to study TH metabolism and develop expertise in a range of laboratory techniques. These involve isolation of blood macrophages and in vitro cell culture for a human ChP model with immune assays and western blot; MS and AD human tissue bank brain and ChP samples for immunohistochemistry and fluorescence microscopy.
Overall, the project explores exciting concepts in macrophage biology, neurobiology, neurology and neuropathology. It is hoped the data will contribute to new clinical imaging and drug trials for MS and AD.
Eligibility
Applicants should have a first or upper second class honours degree in an appropriate biology related subject. A masters qualification or previous laboratory experience within the area of neuroscience would be an advantage.
If your first language is not English, you will need to meet the minimum English requirements for the programme, IELTS Academic score of 6.5 (with no less than 5.5 in each component test area) or equivalent.
The studentship is supported for 3 years and includes full home tuition fees plus a stipend of £18,655 per annum 2024/25 rate. The studentship will only fully fund those applicants who are eligible for home fees with relevant qualifications. Applicants normally required to cover international fees will have to cover the difference between the Home and the international tuition fee rates.
If you wish to discuss this project further informally, please contact Eve Kelland ) or Richard Hosking )
To apply for this position please click on the Apply button above.
Please clearly state the name of the studentship project that you are applying for on the top of your personal statement.
Please see here for a list of supporting documents to upload with your application.
For more information on the admissions process generally, please visit our How to Apply for a Research Degree webpage or contact the Doctoral College.
The closing date for applications is 30th June 2024 at 15:00 (London, UK time). Shortlisted candidates will be invited for interview before the end of July 2024.
The studentship is supported for 3 years and includes full Home tuition fees plus a stipend of £18,655
