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Research Associate in Multiscale Imaging
3 months ago
The extracellular matrix is a complex network of fibrillar proteins, glycoproteins and secreted factors that form complex assemblies essential for tissue structure and function. Most components of the extracellular matrix are large, insoluble multicomponent complexes which are extensively post-translationally modified. Within the Manchester Cell Matrix Centre, we have expertise in imaging all hierarchies of matrix, from high resolution structures of individual matrix proteins to tissue-level imaging. One of our research themes is to now integrate these imaging approaches to visualise matrix across scales. Therefore, the aim of this project is to integrate the imaging from the molecular to the tissue scale. Working with research groups across the Platform and with Facilities (Electron Microscopy, Bioimaging, eBiC and National X-ray Computed Tomography), you will develop 3D imaging approaches (eg cryo-electron tomography of adhesion complexes and correlated microCT and SBF-SEM of tissues) which will be applied to matrix samples, and to integrate these data from different length scales.
Located at The University of Manchester, the Centre is one of eight Discovery Research Platforms recently awarded by the Wellcome Trust. The Discovery Research Platform for Cell-Matrix Biology will address a range of practical, technological, and methodological barriers to understanding how changes in the extracellular matrix leads to tissue failure. We are seeking driven and ambitious individuals to play a pivotal role in overcoming these barriers. Successful candidates will contribute to our bold vision to reprogramme extracellular matrix, which has the potential to lead to innovative new diagnostic tools and treatments for diseases such as cancer and fibrosis. The platform will embrace a Team Science approach and provide an exciting opportunity to work with groups from diverse research areas and collaborate across disciplines.
This is a full time appointment starting 1 August 2024, or as soon as possible thereafter, and is for a fixed term of 3 years. Should the appointment prove successful, there is an opportunity for a further 4 years.
The School is strongly committed to promoting equality and diversity, including the Athena SWAN charter for gender equality in higher education. The School holds a Silver Award which recognises their good practice in relation to gender; including flexible working arrangements, family-friendly policies, and support to allow staff achieve a good work-life balance. We particularly welcome applications from women for this post. Appointment will always be made on merit. For further information, please visit:
What you will get in return:
- Fantastic market leading Pension scheme
- Excellent employee health and wellbeing services including an Employee Assistance Programme
- Exceptional starting annual leave entitlement, plus bank holidays
- Additional paid closure over the Christmas period
- Local and national discounts at a range of major retailers
Our University is positive about flexible working – you can find out more here
Hybrid working arrangements may be considered.
Please note that we are unable to respond to enquiries, accept CVs or applications from Recruitment Agencies.
Any recruitment enquiries from recruitment agencies should be directed to Any CV's submitted by a recruitment agency will be considered a gift.
Enquiries about the vacancy, shortlisting and interviews:
Name: Clair Baldock
Email:
Or
Name: Aleksandr Mironov
Email:
General enquiries:
Email:
Technical support:
This vacancy will close for applications at midnight on the closing date.
£36,024 to £44,263 per annum, depending on relevant experience
