Cell Biologist
3 weeks ago
We are working in partnership with a start-up biotech firm, supporting them in the growth of their scientific team. They're actively seeking Senior and Principal level Scientists to join their Cell Biology team.
Role Summary
In this role you will be a core part of the Biology team, designing assays to examine the binding of TCR bispecific molecules to cells, the activation of T cells and T-cell mediated killing. Ideally, the applicant should be able to make lentivirus and conduct lentiviral transduction of cell lines and primary cells. This will include techniques such as cell culture, flow cytometry, T cell activation and killing assays, mammalian cell transfection/transduction and microscopy.
Key Deliverables
- Working proactively with the team to develop effective in vitro testing strategies prioritised to the needs of the Biology group; collaborating effectively with other research functions.
- Effectively design and conduct experimental work to align with Company priorities and meet scientific timelines, report results succinctly and effectively.
- Design, conduct, analyse experiments to test safety and efficacy of soluble TCR bispecific molecules generated by the Protein Engineering team.
- Dissect molecular mechanisms of T cell activation and T cell mediated killing by soluble TCR bispecific molecules, including establishing and deploying suitable assays and sourcing required cell lines, human organoids and primary human cells and tissue samples.
- Cloning recombinant DNA molecules.
- Making lentiviral supernatants.
- Transduction of cell lines and primary cells with lentivirus.
- Support an in vivo testing strategy via an outsourced model as required.
- Work collaboratively with the Protein Engineering and CMC teams to guide optimisation and development of soluble TCRs.
- Effectively design and conduct experimental work to align with Company priorities and meet scientific timelines, report results succinctly and effectively.
- Present scientific findings and summary conclusions to your department, project team and the company leadership team.
- Drive innovation and continuous improvement within the Cell Biology team, implementing novel technologies, workflows, and methodologies to enhance productivity and accelerate the drug development process
Experience & Qualifications Required
- Familiarity with a range of cell and molecular biology techniques, such as flow cytometry analysis, designing and executing recombinant DNA sub-cloning strategies, making lentiviral supernatants, lentiviral transduction, T cell assays.
- Direct hands-on laboratory experience in testing and developing of biologics including the assessment of the biological impact of their engagement with therapeutic targets.
- (Desired but not essential) Experience in the design and oversight of in vivo experiments.
- Experience leading projects, overseeing the experimental strategy and co-ordinating the work of other team members.
- A PhD in a relevant biological subject with or without post-doctoral experience in academia and with substantial subsequent biotechnology and/or pharmaceutical industry experience in R&D teams.
- (Desired) Experience managing a team of scientists.
- (Desired) Experience leading in a matrix environment.
- Ability to independently lead programmes to advance the company’s goals, review competing priorities and recommend strategies to advance the programme.
- Working proactively with the team to develop effective strategies prioritised to the needs of the Biology group; collaborating effectively with other functions.
- Inclusive, collaborative, and thrives in a team environment with a flexible approach to working.
- Strong communication skills with the confidence and judgement to challenge appropriately.
- Demonstrable problem- solving ability, creative thinking and be pro-active in driving the project forwards
-
Cell Biologist
1 week ago
Oxfordshire, United Kingdom Hlx Life Sciences Full timeJob DescriptionWe are working in partnership with a start-up biotech firm, supporting them in the growth of their scientific team. They're actively seeking Senior and Principal level Scientists to join their Cell Biology team. Role SummaryIn this role you will be a core part of the Biology team, designing assays to examine the binding of TCR bispecific...
-
Cell Biologist
3 weeks ago
Oxfordshire, United Kingdom Hlx Life Sciences Full timeWe are working in partnership with a start-up biotech firm, supporting them in the growth of their scientific team. They're actively seeking Senior and Principal level Scientists to join their Cell Biology team. Role Summary In this role you will be a core part of the Biology team, designing assays to examine the binding of TCR bispecific molecules to...
-
Cell Biologist
3 weeks ago
Oxfordshire, United Kingdom Hlx Life Sciences Full timeWe are working in partnership with a start-up biotech firm, supporting them in the growth of their scientific team. They're actively seeking Senior and Principal level Scientists to join their Cell Biology team. Role Summary In this role you will be a core part of the Biology team, designing assays to examine the binding of TCR bispecific molecules to...
-
Cell Biologist
3 weeks ago
Oxfordshire, United Kingdom Hlx Life Sciences Full timeWe are working in partnership with a start-up biotech firm, supporting them in the growth of their scientific team. They're actively seeking Senior and Principal level Scientists to join their Cell Biology team. Role SummaryIn this role you will be a core part of the Biology team, designing assays to examine the binding of TCR bispecific molecules to cells,...
-
Cell Biologist
4 days ago
Oxfordshire, United Kingdom Hlx Life Sciences Full timeJob Description We are working in partnership with a start-up biotech firm, supporting them in the growth of their scientific team. They're actively seeking Senior and Principal level Scientists to join their Cell Biology team. Role Summary In this role you will be a core part of the Biology team, designing assays to examine the binding of TCR...
-
Cell Biologist
3 weeks ago
Oxfordshire, United Kingdom Hlx Life Sciences Full timeWe are working in partnership with a start-up biotech firm, supporting them in the growth of their scientific team. They're actively seeking Senior and Principal level Scientists to join their Cell Biology team. Role Summary In this role you will be a core part of the Biology team, designing assays to examine the binding of TCR bispecific molecules to...
-
Cell Biologist
3 weeks ago
Oxfordshire, United Kingdom Hlx Life Sciences Full timeWe are working in partnership with a start-up biotech firm, supporting them in the growth of their scientific team. They're actively seeking Senior and Principal level Scientists to join their Cell Biology team. In this role you will be a core part of the Biology team, designing assays to examine the binding of TCR bispecific molecules to cells, the...
-
Cell Biologist
3 weeks ago
Oxfordshire, United Kingdom Hlx Life Sciences Full timeWe are working in partnership with a start-up biotech firm, supporting them in the growth of their scientific team. They're actively seeking Senior and Principal level Scientists to join their Cell Biology team. In this role you will be a core part of the Biology team, designing assays to examine the binding of TCR bispecific molecules to cells, the...
-
Cell Biologist
4 days ago
Oxfordshire, United Kingdom Hlx Life Sciences Full timeJob Description We are working in partnership with a start-up biotech firm, supporting them in the growth of their scientific team. They're actively seeking Senior and Principal level Scientists to join their Cell Biology team. In this role you will be a core part of the Biology team, designing assays to examine the binding of TCR bispecific molecules to...
-
Associate Scientist
1 month ago
Oxford, Oxfordshire, United Kingdom BioIndustry Association Full timeT-Cypher Bio - Molecular Biologist Position T-Cypher Bio is an early-stage, innovative biotechnology company aiming to unlock an expansive target space to build a pipeline of novel, TCR-based therapeutics. We are seeking a highly motivated Molecular Biologist to join our team. The successful candidate will be responsible for conducting experiments related...
-
Associate Director
4 days ago
Oxford, Oxfordshire, United Kingdom Singular: Building Brilliant Biotechs Full timeCell Biology Leader // Immunology // Oxford Read the overview of this opportunity to understand what skills, including and relevant soft skills and software package proficiencies, are required. Do you think you have what it takes to develop and lead a team discovering drugs targeting the non-coding regions of the genome? Why did you pursue a career in...
-
Associate Director
4 days ago
Oxford, Oxfordshire, United Kingdom Singular: Building Brilliant Biotechs Full timeJob Description Cell Biology Leader // Immunology // Oxford Do you think you have what it takes to develop and lead a team discovering drugs targeting the non-coding regions of the genome? Why did you pursue a career in biotech? Was it to uncover new ways of helping patients? We are on the look-out for a Cell Biology Leader with an expertise in immunology...
-
Associate Director
1 month ago
Oxford, Oxfordshire, United Kingdom Singular: Building Brilliant Biotechs Full timeCell Biology Leader // Immunology // Oxford Do you think you have what it takes to develop and lead a team discovering drugs targeting the non-coding regions of the genome? Why did you pursue a career in biotech? Was it to uncover new ways of helping patients? We are on the look-out for a Cell Biology Leader with an expertise in immunology who is looking...
-
Associate Director
1 month ago
Oxford, Oxfordshire, United Kingdom Singular: Building Brilliant Biotechs Full timeCell Biology Leader // Immunology // Oxford Do you think you have what it takes to develop and lead a team discovering drugs targeting the non-coding regions of the genome? Why did you pursue a career in biotech? Was it to uncover new ways of helping patients? We are on the look-out for a Cell Biology Leader with an expertise in immunology who is looking...
-
Team Leader
23 hours ago
Oxford, Oxfordshire, United Kingdom Nucleome Full timeLOCATION: The Schrodinger Building, Oxford Science Park , Oxford HOURS: Full-time CONTRACT TYPE: Permanent NUCLEOME THERAPEUTICS , a fast-growing biopharma that is building a passionate, creative, and dedicated multi-disciplinary team of scientists with expertise in gene regulation, genomics, machine learning, drug discovery, data analysis and...
