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Principal Scientist, in vivo

1 month ago

Oxfordshire, United Kingdom CK Group Full time

CK Group are recruiting for a proactive Principal Scientist, with a strong background in cancer biology and tumour microenvironment, to join a growing biotechnology company, on a permanent basis, to be based in Oxford.

This is a great opportunity for a highly motivated scientist, with a commitment to research on anti-cancer therapies to take responsibility in a fast-paced environment, working within an interdisciplinary team to develop new cancer treatments.


The Role:

Contributing to strategic R&D goals you will be designing, managing, and performing oncolytic immunotherapy studies to support candidate development and inform clinical strategy. The successful will focus on the actions and influence on the tumour microenvironment, and application in new tumour indications.


Your responsibilities will include:

  • Responsible for study plan design and approval, as well as overseeing data collection, analysis, reporting and for the final conclusions from the study report including sign off.
  • Design and execution of R&D projects.
  • Act as independent scientist reviewer and sign off lab books, verifying the calculations, and approving SOPs.
  • Act as mentor and supervisor.
  • Contributing to presentations, reports and regulatory filings.


Your Background:

  • PhD degree or equivalent in a relevant scientific discipline with strong industry expertise in cancer biology and scientific acumen in tumour microenvironment.
  • Significant level of hands on experience in performing in-vivo experiments in oncology models for drug discovery (preferably in humanised immune mouse models).
  • Experience performing i.t. / i.v / i.p injections.
  • Good knowledge of Mode of action, Tumour Micro-environment and spatial transcriptomics/RNA scope.
  • Technical experience on qPCR, RNA/DNA extractions, ELISA and cell-based assays.
  • Active animal licence from the Home Office (DESIRABLE).
  • Experience of in vivo imaging (e.g. bioluminescence), IHC / flow cytometry/ multiplex immunofluorescence.
  • Skilled in bioinformatic analysis.


Benefits:

  • Bonus.
  • Pension.
  • Private Medical Insurance.
  • Flexible working hours.


Apply:

It is essential that applicants hold entitlement to work in the UK. Please quote job reference 121585 in all correspondence.