Current jobs related to Senior Director, DMPK - Great Abington - ISTITUTO MARANGONI
-
Senior Care Home Director
2 weeks ago
Great Yarmouth, United Kingdom Apex Careers and Staffing Limited Full timeJob Summary:We are seeking a highly skilled and experienced Senior Care Home Director to join our team at Apex Careers and Staffing Limited. As a Senior Care Home Director, you will be responsible for leading and managing the day-to-day operations of our care home, ensuring the highest standards of care and service delivery.Key Responsibilities:Leadership...
-
Senior Care Home Director
2 weeks ago
Great Yarmouth, United Kingdom Apex Careers and Staffing Limited Full timeJob Summary:We are seeking a highly skilled and experienced Senior Care Home Director to join our team at Apex Careers and Staffing Limited. As a Senior Care Home Director, you will be responsible for leading and managing the day-to-day operations of our care home, ensuring the highest standards of care and service delivery.Key Responsibilities:Leadership...
-
Operational Finance Director
1 week ago
Great Burdon, United Kingdom Intertek Full timeAbout the OpportunityWe are seeking a highly skilled and experienced Finance Operations Manager to join our Lintec business unit at Intertek. As a key member of the Lintec Management Team, you will provide management information to Lintec Senior Management and attend daily meetings.Key Responsibilities:Provide the Director and Management Team with monthly...
-
Operational Finance Director
1 week ago
Great Burdon, United Kingdom Intertek Full timeAbout the OpportunityWe are seeking a highly skilled and experienced Finance Operations Manager to join our Lintec business unit at Intertek. As a key member of the Lintec Management Team, you will provide management information to Lintec Senior Management and attend daily meetings.Key Responsibilities:Provide the Director and Management Team with monthly...
-
Operational Finance Director
2 weeks ago
Great Burdon, United Kingdom Intertek Full timeAbout the OpportunityWe are seeking a highly skilled and experienced Financial Operations Manager to join our Lintec business unit as a key member of the Management Team.Key ResponsibilitiesProvide management information to Lintec Senior Management and attend daily meetings.Review, understand, and manage the Lintec Profit and Loss account during month-end,...
-
Operational Finance Director
2 weeks ago
Great Burdon, United Kingdom Intertek Full timeAbout the OpportunityWe are seeking a highly skilled and experienced Finance Operations Manager to join our Lintec business unit as a key member of the Management Team.Key ResponsibilitiesProvide management information to Lintec Senior Management and attend daily meetings.Review, understand, and manage the Lintec Profit and Loss account during month-end,...
-
Operational Finance Director
2 weeks ago
Great Burdon, United Kingdom Intertek Full timeAbout the OpportunityWe are seeking a highly skilled and experienced Finance Operations Manager to join our Lintec business unit as a key member of the Management Team.Key ResponsibilitiesProvide management information to Lintec Senior Management and attend daily meetings.Review, understand, and manage the Lintec Profit and Loss account during month-end,...
-
Interim Service Director
4 months ago
Great Yarmouth, United Kingdom Norfolk and Suffolk NHS Foundation Trust Full timeAre you passionate about fostering compassionate leadership and driving quality improvement in healthcare? Look no further! Our Care Group is seeking a dynamic individual to join us as a Service Director for a 6 month fixed term / secondment opportunity. At our core, we believe in creating a culture where every voice matters. We prioritise collaboration...
-
Interim Service Director
4 months ago
Great Yarmouth, United Kingdom Norfolk & Suffolk Foundation Trust Full timeNorfolk and Suffolk NHS Foundation Trust provides child and adult mental health services, learning disability, wellbeing, older people's and eating disorder services across Norfolk and Suffolk. At any one time, around 23,000 people in Norfolk and Suffolk are receiving care and attention from the Trust. We believe in whole life care - seeing people in the...
-
Tax Senior Specialist
9 hours ago
Great Yarmouth, Norfolk, United Kingdom Clark Wood - Tax Recruitment Full timePersonal Tax Senior OpportunityClark Wood - Tax Recruitment is working with a highly progressive and expanding firm of chartered accountants in the UK who are looking to add a Personal Tax Senior / Supervisor to their team.Key Responsibilities:Manage a portfolio of personal tax clients, including HNWIs, company directors, and sole traders, ensuring accurate...
-
Tax Senior Specialist
7 hours ago
Great Yarmouth, Norfolk, United Kingdom Clark Wood - Tax Recruitment Full timePersonal Tax Senior OpportunityClark Wood - Tax Recruitment is working with a highly progressive and expanding firm of chartered accountants in the UK who are looking to add a Personal Tax Senior / Supervisor to their team.Key Responsibilities:Manage a portfolio of personal tax clients, including HNWIs, company directors, and sole traders, ensuring accurate...
-
Care Home Director
2 weeks ago
Great Yarmouth, Norfolk, United Kingdom Appoint Healthcare Full time £60,000About the Role:We are seeking a highly skilled and experienced Care Home Director to lead our team at Appoint Healthcare. As a key member of our management team, you will be responsible for overseeing the daily operations of our care home, ensuring the highest standards of care and service delivery.Key Responsibilities:Lead and manage a team of care...
-
Care Home Director
2 weeks ago
Great Yarmouth, Norfolk, United Kingdom Appoint Healthcare Full time £60,000About the Role:We are seeking a highly skilled and experienced Care Home Director to lead our team at Appoint Healthcare. As a key member of our management team, you will be responsible for overseeing the daily operations of our care home, ensuring the highest standards of care and service delivery.Key Responsibilities:Lead and manage a team of care...
-
Tax Senior Specialist
2 weeks ago
Great Yarmouth, Norfolk, United Kingdom Clark Wood - Tax Recruitment Full timeClark Wood, a leading recruitment consultancy, is working with a highly progressive and expanding firm of chartered accountants to find a Tax Senior Specialist to join their team.The role involves managing a portfolio of personal tax clients, including high net worth individuals, company directors, and sole traders. The successful candidate will be...
-
Tax Senior Specialist
2 weeks ago
Great Yarmouth, Norfolk, United Kingdom Clark Wood - Tax Recruitment Full timeClark Wood, a leading recruitment consultancy, is working with a highly progressive and expanding firm of chartered accountants to find a Tax Senior Specialist to join their team.The role involves managing a portfolio of personal tax clients, including high net worth individuals, company directors, and sole traders. The successful candidate will be...
-
Tax Senior Specialist
4 days ago
Great Yarmouth, Norfolk, United Kingdom Clark Wood - Tax Recruitment Full timePersonal Tax Senior OpportunityClark Wood, a leading recruitment consultancy, is partnering with a progressive and expanding firm of chartered accountants to find a skilled Personal Tax Senior to join their team.Key Responsibilities:Manage a portfolio of personal tax clients, including high net worth individuals, company directors, and sole traders.Ensure...
-
Tax Senior Specialist
4 days ago
Great Yarmouth, Norfolk, United Kingdom Clark Wood - Tax Recruitment Full timePersonal Tax Senior OpportunityClark Wood, a leading recruitment consultancy, is partnering with a progressive and expanding firm of chartered accountants to find a skilled Personal Tax Senior to join their team.Key Responsibilities:Manage a portfolio of personal tax clients, including high net worth individuals, company directors, and sole traders.Ensure...
-
Senior Nurse Director
3 weeks ago
Great Missenden, Buckinghamshire, United Kingdom Operose Health Full timeJob SummaryOperose Health is seeking a highly skilled Senior Nurse Manager to lead our nursing service in a designated region. As a key member of our team, you will be responsible for ensuring high-quality patient care and compliance with organizational policies.Key ResponsibilitiesLead and manage a team of nurses to deliver exceptional patient careDevelop...
-
Senior Nurse Director
3 weeks ago
Great Missenden, Buckinghamshire, United Kingdom Operose Health Full timeJob SummaryOperose Health is seeking a highly skilled Senior Nurse Manager to lead our nursing service in a designated region. As a key member of our team, you will be responsible for ensuring high-quality patient care and compliance with organizational policies.Key ResponsibilitiesLead and manage a team of nurses to deliver exceptional patient careDevelop...
-
Senior Nurse Director
3 weeks ago
Great Missenden, Buckinghamshire, United Kingdom Operose Health Full timeJob SummaryOperose Health is seeking a highly skilled Senior Nurse Manager to lead our nursing service in a designated region. As a key member of our team, you will be responsible for ensuring high-quality patient care and compliance with organizational policies.Key ResponsibilitiesLead and manage a team of nurses to deliver exceptional patient careDevelop...
Senior Director, DMPK
4 months ago
Company Description
Bicycle Therapeutics is a clinical-stage biopharmaceutical company developing a novel class of medicines, referred to as Bicycle molecules, for diseases that are underserved by existing therapeutics. Bicycle molecules are fully synthetic short peptides constrained with small molecule scaffolds to form two loops that stabilize their structural geometry. This constraint facilitates target binding with high affinity and selectivity, making Bicycle molecules attractive candidates for drug development. The company is evaluating BT8009, a Bicycle Toxin Conjugate (BTC) targeting Nectin-4, a well-validated tumor antigen; BT5528, a BTC targeting EphA2, a historically undruggable target; and BT7480, a Bicycle Tumor-Targeted Immune Cell Agonist (Bicycle TICA) targeting Nectin-4 and agonizing CD137, in company-sponsored clinical trials. Additionally, the company is developing Bicycle Radio Conjugates (BRC) for radiopharmaceutical use and, through various partnerships, is exploring the use of Bicycle technology to develop therapies for diseases beyond oncology.
Bicycle Therapeutics is headquartered in Cambridge, UK, with many key functions and members of its leadership team located in Cambridge, MA.
Culture is key and all Bicycle employees actively embrace and role model our company values:
- Weare Adventurous .We believe it’sthewaytodeliverextraordinaryresultsforourpatients.
- Weare DedicatedtoourMission .Youcan’tchangetheworldifyoudon’thavedetermination.
- Weare OneTeam .Weonlysucceedwhenweworktogether.
The Senior Director of Drug Metabolism and Pharmacokinetics (DMPK) reports to the Vice President of Quantitative Pharmacology group. In partnership with drug discovery medicinal chemists, biologists, pharmacologists and toxicologists, you will be responsible for leading a small team of DMPK scientists supporting multiple projects from target identification through to candidate selection and ultimately regulatory submission.
- Provide DMPK scientific leadership across all stages of the portfolio.
- Oversee the quality and performance of all DMPK activities including interactions with external CRO’s and internal project stakeholders.
- Work collaboratively with other core disciplines to support compound progression based on optimizing DMPK properties.
- Integrate data from multiple sources to inform on the understanding of bicyclic peptide distribution, metabolism and excretion.
- Work closely with in-vivo pharmacology to design experiments to understand preclinical pharmacokinetic/pharmacodynamic (pk/pd) relationships.
- Work closely with discovery team and regulatory team to author and review DMPK related IND documents
- Managing DMPK budgets for CRO’s and monitoring CROs to ensure delivery of quality data on time.
- Support leadership of the Quantitative Pharmacology group and junior staff development
Essential:
- PhD in relevant scientific discipline such as drug metabolism, pharmacology, pharmaceutical sciences.
- Significant experience working on DMPK drug discovery and/or development projects with a track record of successful delivery.
- In depth understanding of DMPK science with additional knowledge of related disciplines.
- Demonstrated expertise in DMPK problem solving across drug discovery.
- Ability to adapt your working style to suit different cultures and partner expectations in both remote and office-based environment.
- Excellent organisation and communication skills, both written and oral, with the ability to influence.
Desirable:
- Previous experience working on peptides-macrocycles would be an advantage.
- Nice-to-have: experience on radio-pharm projects
- State-of-the-art campus environmentwith on campus restaurant and Montessori nursery
- Flexible working environment
- Competitive reward including annual company bonus
- Employee recognition schemes
- 28 days annual leave in addition to bank holidays+ option to buy up to 5 additional days annually
- Employer contribution to pension (employee does not have to contribute)
- Life assurance cover 4x basic salary
- Private Medical Insurance, including optical and dental cover
- Enhanced parental leave policies
- Group income protection
- Employee assistance program
- Health Cash Plan
- Access to company subsidized gym membership
- Eligibility for an option grant to subscribe to shares in Bicycle Therapeutics plc.
- Cycle to work scheme
All your information will be kept confidential according to EEO guidelines.
Bicycle Therapeutics is committed to building a diverse workforce that is representative of the communities we serve. We recognize that diverse and inclusive teams build a stronger and more innovative company. Therefore, all qualified applicants will be considered for employment, and we do not discriminate on the basis of race, religion, colour, gender, sexual orientation, age, disability status, marital status, or veteran status.
#J-18808-Ljbffr