Postdoctoral Researcher in Microglial Pathophysiology in Alzheimer's Disease
7 days ago
We have an excellent opportunity for a Postdoctoral Researcher in Microglial Pathophysiology in Alzheimer's Disease to join the newly established multidisciplinary Oxford-GSK Institute of Molecular and Computational Medicine (IMCM), operating within Nuffield Department of Medicine (NDM) in collaboration with Nuffield Department of Clinical Neuroscience (NDCN), Sir William Dunn School of Pathology, Department of Psychiatry and Department of Physiology, Anatomy and Genetics (DPAG).
You will be responsible for culturing and manipulating human induced Pluripotent Stem Cell lines and undertaking their differentiation to microglia and neurons. You will optimise methodologies for isolation of aggregated proteins from Alzheimer's brains. This will involve advanced methodologies for detection and quantification of aggregated protein species, including RT-QuIC and mass-spectroscopy; and also, be involved in purification of recombinant aggregation-prone proteins, using liquid chromatography (AKTA). You will design, validate, troubleshoot, and perform relevant assays to interrogate dysregulation induced in iPS-microglia by exposure to material from Alzheimer's brains. This will require standard cell and molecular biology methodologies, including qPCR, Western Blot, FACs, pharmacological and CRISPR-mediated genetic manipulation of intracellular signalling/trafficking pathways, cytokine immunoassays (ELISAs, bioassays), high content imaging (Opera Phenix) and automated image analysis. It will also involve processing of samples for multi-omics analyses (transcriptomics, proteomics, lipidomics).
It is essential that you hold a PhD (or be close to completion) in neuroscience, cell/molecular biology or immunology. You will have experience in cell culture, preferably human pluripotent stem cells and in molecular biology methodologies including qPCR, Western Blot, FACs, and setting up cellular assays, such as cytokine immunoassays (ELISAs, bioassays), preferably including image-based experiments. The knowledge of stem cell reprogramming and the differentiation of iPSCs into neuronal and glial cultures and the ability to conduct high quality research and produce relevant publications. Experience of protein biochemistry and purification of recombinant proteins using liquid chromatography and/or knowledge of neuroinflammation is desirable but not an essential requirement.
Applications for this vacancy are to be made online and you will be required to upload a supporting statement and CV as part of your online application. Your supporting statement must explain how you meet each of the selection criteria for the post using examples of your skills and experience.
This position is offered full time on a fixed term contract until 30 September 2027 and is funded by GSK.
Only applications received before 12 midday on Tuesday 18 June 2024 will be considered. Please quote 172864 on all correspondence.
£36,024 to £44,263 per annum. Grade 7
#J-18808-Ljbffr-
Oxford, Oxfordshire, United Kingdom University of Oxford Full timeWe have an excellent opportunity for a Postdoctoral Researcher in Microglial Pathophysiology in Alzheimer's Disease to join the newly established multidisciplinary Oxford-GSK Institute of Molecular and Computational Medicine (IMCM), operating within Nuffield Department of Medicine (NDM) in collaboration with Nuffield Department of Clinical Neuroscience...
-
Oxford, Oxfordshire, United Kingdom University of Oxford Full timeWe have an excellent opportunity for a Postdoctoral Researcher in Microglial Pathophysiology in Alzheimer's Disease to join the newly established multidisciplinary Oxford-GSK Institute of Molecular and Computational Medicine (IMCM), operating within Nuffield Department of Medicine (NDM) in collaboration with Nuffield Department of Clinical Neuroscience...
-
Oxford, Oxfordshire, United Kingdom University of Oxford Full timeWe have an excellent opportunity for a Postdoctoral Researcher in Microglial Pathophysiology in Alzheimer's Disease to join the newly established multidisciplinary Oxford-GSK Institute of Molecular and Computational Medicine (IMCM), operating within Nuffield Department of Medicine (NDM) in collaboration with Nuffield Department of Clinical Neuroscience...
-
Oxford, Oxfordshire, United Kingdom University of Oxford Full timeWe are seeking to appoint a Postdoctoral Researcher in Alzheimer's Disease Pathology to join Professor Laura Parkkinen's research group. This post provides an exciting opportunity to join the newly established multidisciplinary Oxford-GSK Institute of Molecular and Computational Medicine (IMCM) operating within Nuffield Department of Medicine (NDM) in...
-
Researcher (Fixed Term)
1 week ago
Oxford, Oxfordshire, United Kingdom Economicsnetwork Full time £172,864We have an excellent opportunity for a Postdoctoral Researcher in Microglial Pathophysiology in Alzheimer's Disease to join the newly established multidisciplinary Oxford-GSK Institute of Molecular and Computational Medicine (IMCM), operating within Nuffield Department of Medicine (NDM) in collaboration with Nuffield Department of Clinical Neuroscience...
-
Oxford, Oxfordshire, United Kingdom University of Oxford Full timeWe have an excellent opportunity for a Postdoctoral Researcher in Protein Quantification in Alzheimer's Disease to join the newly established multidisciplinary Oxford-GSK Institute of Molecular and Computational Medicine (IMCM), operating within Nuffield Department of Medicine (NDM) in collaboration with Nuffield Department of Clinical Neuroscience (NDCN),...
-
Oxford, Oxfordshire, United Kingdom University of Oxford Full timeWe have an excellent opportunity for a Postdoctoral Researcher in Protein Quantification in Alzheimer's Disease to join the newly established multidisciplinary Oxford-GSK Institute of Molecular and Computational Medicine (IMCM), operating within Nuffield Department of Medicine (NDM) in collaboration with Nuffield Department of Clinical Neuroscience (NDCN),...
-
Oxford, Oxfordshire, United Kingdom University of Oxford Full timeLocation: John Radcliffe Hospital, West Wing, Headley Way, Oxford, OX3 9DU. And on occasion, Building of Genomic Medicine, Old Road Campus, Roosevelt Drive, Headington, Oxford, OX3 7BNWe are seeking to appoint a Postdoctoral Researcher in Alzheimer's Disease Pathology to join Professor Laura Parkkinen's research group. This post provides an exciting...
-
Oxford, Oxfordshire, United Kingdom University of Oxford Full timeLocation: John Radcliffe Hospital, West Wing, Headley Way, Oxford, OX3 9DU. And on occasion, Building of Genomic Medicine, Old Road Campus, Roosevelt Drive, Headington, Oxford, OX3 7BNWe are seeking to appoint a Postdoctoral Researcher in Alzheimer's Disease Pathology to join Professor Laura Parkkinen's research group. This post provides an exciting...
-
Postdoctoral Research Scientist
2 months ago
Oxford, Oxfordshire, United Kingdom University of Oxford Full timeWe have an exciting opportunity for a Postdoctoral Research Scientist with expertise in endo-lysosomal biology and biochemical aspects of the ubiquitin-proteasome system (UPS)to join the Alzheimer's Research UK Oxford Drug Discovery Institute (ARUK-ODDI) based at the Centre for Medicines Discovery, Nuffield Department of Medicine.You will be responsible for...
-
Postdoctoral Research Scientist
3 weeks ago
Oxford, Oxfordshire, United Kingdom University of Oxford Full timeWe have an exciting opportunity for a Postdoctoral Research Scientist with expertise in endo-lysosomal biology and biochemical aspects of the ubiquitin-proteasome system (UPS)to join the Alzheimer's Research UK Oxford Drug Discovery Institute (ARUK-ODDI) based at the Centre for Medicines Discovery, Nuffield Department of Medicine.You will be responsible for...
-
Postdoctoral Researcher
3 weeks ago
Oxford, Oxfordshire, United Kingdom University of Oxford Full timeAbout the RoleWe are looking for an academically driven postdoctoral researcher to join our interdisciplinary team, exploring how fibroblast cues regulate fibrotic niches in the human and mouse intestine. You will be applying a range of molecular biology techniques (e.g., single cell/spatial transcriptomics & proteomics) to profile patient cohort samples and...
-
Postdoctoral Researcher
2 months ago
Oxford, Oxfordshire, United Kingdom University of Oxford Full timeAbout the RoleWe are looking for an academically driven postdoctoral researcher to join our interdisciplinary team, exploring how fibroblast cues regulate fibrotic niches in the human and mouse intestine. You will be applying a range of molecular biology techniques (e.g., single cell/spatial transcriptomics & proteomics) to profile patient cohort samples and...
-
Oxford, Oxfordshire, United Kingdom University of Oxford Full timeWe are seeking a motivated and enthusiastic Postdoctoral Research Associate in Sleep Medicine to join the Experimental and Clinical Sleep Medicine group within the Nuffield Department of Clinical Neurosciences. We conduct human experimental and clinical studies on sleep and disorders of sleep with the aim of understanding their pathophysiology and...
-
Postdoctoral Research Scientist
2 months ago
Oxford, Oxfordshire, United Kingdom University of Oxford Full timeWe have an exciting opportunity for a Postdoctoral Research Scientist to join the newly established multidisciplinary Oxford-GSK Institute for Molecular & Computational Medicine (IMCM) operating within Nuffield Department of Medicine (NDM) in collaboration with Nuffield Department of Clinical Neuroscience (NDCN), Nuffield Department of Population Health...
-
Postdoctoral Research Scientist
3 weeks ago
Oxford, Oxfordshire, United Kingdom University of Oxford Full timeWe have an exciting opportunity for a Postdoctoral Research Scientist to join the newly established multidisciplinary Oxford-GSK Institute for Molecular & Computational Medicine (IMCM) operating within Nuffield Department of Medicine (NDM) in collaboration with Nuffield Department of Clinical Neuroscience (NDCN), Nuffield Department of Population Health...
-
Postdoctoral Research Scientist
1 day ago
Oxford, Oxfordshire, United Kingdom University of Oxford Full timeLocation: Target Discovery Institute, NDM Research Building, Old Road Campus, Headington, Oxford, OX3 7FZWe have an exciting opportunity to recruit a highly motivated Postdoctoral Research Scientist to join our fantastic research team here at the Target Discovery Institute, Nuffield Department of Medicine. The Song research group aims to decode the chemical...
-
Postdoctoral Research Assistant
7 days ago
Oxford, Oxfordshire, United Kingdom University of Oxford Full timeThis post is fixed-term until 31 March 2025. COVID-19 and avian influenza are potent reminders of our collective vulnerability to infectious diseases. This is an excellent opportunity for a bright and enthusiastic researcher to develop their career in statistical epidemiology within the internationally leading Department of Statistics in the University of...
-
Postdoctoral Researcher
7 days ago
Oxford, Oxfordshire, United Kingdom University of Oxford Full timePostdoctoral position evaluating trial designs for a Lassa Fever vaccine at the Centre for Tropical Medicine and Global Health, University of Oxford.This is an exciting opportunity to join a team dedicated to developing a Lassa fever vaccine based on the ChAdOx platform that was the basis for successful Ebola and COVID-19 vaccines.You will conduct modelling...
-
Research Scientist
1 week ago
Oxford, Oxfordshire, United Kingdom Professor Doctor Obi Full timeWe have an exciting opportunity for a Postdoctoral Research Scientist with expertise in endo-lysosomal biology and biochemical aspects of the ubiquitin-proteasome system (UPS)to join the Alzheimer's Research UK Oxford Drug Discovery Institute (ARUK-ODDI) based at the Centre for Medicines Discovery, Nuffield Department of Medicine. You will be responsible...
