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Early Phase Team Lead

3 months ago


Whitchurch, Shropshire, United Kingdom Velindre Cancer Centre Full time

A collaborative model of research delivery has been agreed and Velindre University NHS Trust (VUNHST) has collaborated with Health and Care Research Wales and BioNTech, pharmaceutical company, to deliver the BioNTech clinical trial portfolio, which includes new advanced therapies such as mRNA cancer vaccine studies and other immunotherapeutic Clinical Trials of Investigative Medicinal Products (CTIMPs).


This exciting role will provide management oversite at 2 research delivery sites, managing a highly skilled team delivering cutting-edge new research.

To be successful in this role you need to be experienced in clinical research, and have proven management skills.

You need to demonstrate excellent leadership qualities, communication and organisational skills and have a comprehensive knowledge of the ethical, financial, organisational and regulatory environment in which clinical research is delivered.

This post is Fixed Term or Secondment for up to 24 months, to meet the needs of the service.

  • Provide nurse management oversite to support the delivery of new novel cancer therapies including advanced therapies such as mRNA cancer vaccine studies and other immunotherapeutic Clinical Trials.
  • Manage the trials within the Multidisciplinary Team
  • Supervise, advise and develop a research team.
  • Deputise for Band 8a in their absence.
The ability to speak Welsh is desirable for this post; Welsh and/or English speakers are equally welcome to apply.


Here at Velindre University NHS Trust we are extremely proud of the specialist services we provide across the whole of Wales in our cutting-edge Velindre Cancer Centre and our award-winning Welsh Blood Service, as well as the expertise of our corporate functions that bring the two divisions together.

We are also fortunate to host the NHS Wales Shared Services Partnership and Health Technology Wales and have developed strong partnership working with these expert services.


If you want to work for an organisation that prides itself on making a real difference and offers exciting career opportunities then Velindre University NHS Trust is the place for you.


Communicate competently complex information about specific clinical trials and their consequences, to patients and carers ensuring they have a good understanding of treatment options, thereby ensuring high standards of informed consent.


To act as the key worker for patients in your direct care for the duration of active involvement in a clinical trial, ensuring that all patients, carers and appropriate community colleagues are well informed about their disease and its management, providing appropriate and timely information.


Work in partnership with clinical investigators with all aspects of a clinical trial, including: trial set up, trial documentation, data collection, administration and patient recruitment and treatment coordination.


Registered general nurse / practitioner with evidence of highly developed knowledge in oncology and clinical research to include well developed leadership and managerial skills.

Educated to Masters level or equivalent experience or qualification.


Takes personal responsibility for lifelong learning and personal development through clinical supervision, appraisal and knowledge and skills framework, actively engaging with learning and development opportunities in response to emerging knowledge and techniques.


Work autonomously to manage a large caseload of patients acting as a professional nurse in ensuring a duty of care to the patient and their families.


To be able to provide an expert opinion on the creation and coordination of the disease specific portfolio in collaboration with the MDT.

Judgements on information giving for conflicting studies.

Assessing the feasibility of running a trial in VUNHST and CVUHB.

Participate in service reviews in order to instigate and manage change and service improvement within a complex department.

Influence and develop policy and clinical guidelines internally and externally.

Lead on the contribution to the early phase service development, ensuring pursuit of excellence in care for trials patients.


Work with the R&D Delivery Manager, and RD& I finance Manager in assessing the financial impact to the Trust and CVUHB of commercial and non-commercial trials.

Financial Initiative - Deal with financial negotiations and contractual agreements with pharmaceutical companies when setting up a clinical trial.

Identify and discuss with individual departments the physical resource implications.


Mentor new research staff and provide training in own discipline and that of other Clinical Trials Unit posts of Band 6 and below as required.

Managing and supervising an early phase team. Implementing annual PADRs

Ensure continued effective registration with the NMC and be aware of NMC Code of Professional Conduct. They must be accountable for their own practice. Work within the NMC Scope of Professional Practice and ensure competency to undertake duti