Research Associate
2 weeks ago
Salary:
£33,966 to £36,024 per annum
Newcastle University is a great place to work, with excellent benefits.
We have a generous holiday package; plus the opportunity to buy more, great pension schemes and a number of health and wellbeing initiatives to support you.
Closing Date: 01 June 2024
The Role
This position provides an opportunity for an outstanding Research Associate to develop their career within a team that brings together clinicians and academics in a vibrant translational research environment that works closely with patients and their families.
You will be skilled in kidney research, translational research and have demonstrable experience with murine models of kidney development/disease, with a recent PhD in this area.
We are looking for an exceptional individual able to lead on laboratory molecular techniques as well as perform in vivo experiments and interpret the findings.
Mutations affecting the structure/function of primary cilia cause a heterogenous group of complex disorders that typically progress to end stage renal failure (ESFR) with dialysis and transplantation the only current treatment.
Renal ciliopathies account for 10% of all patients with kidney failure and represent the main cause of ESRF during childhood.
Although mutations in over 40 genes have been shown to underlie the renal ciliopathies, extensive genotype:phenotype heterogeneity means it is difficult to predict the severity of the disease and the rate of progression to ESRF.
TheRaCil, aims to use models of renal ciliopathy diseases to drive translational research and bring treatments to the clinic within the next 5 years, see Ramsbottom SA, Molinari E, Srivastava S, Silberman F, Henry C, Alkanderi S, Devlin LA, White K, Steel DH, Saunier S, Miles CG, Sayer JA.
Targeted exon skipping of a CEP290 mutation rescues Joubert syndrome phenotypes in vitro and in a murine model.Proc Natl Acad Sci USA :
PMID:
; Ramsbottom SA, Thelwall PE, Wood KM, Clowry GJ, Devlin LA, Silbermann F, Spiewak HL, Shril S, Molinari E, Hildebrandt F, Gunay-Aygun M, Saunier S, Cordell HJ, Sayer JA, Miles CG. Mouse genetics reveals Barttin as a genetic modifier of Joubert syndrome.
Proc Natl Acad Sci USA :
PMID:
; and Garcia H, Serafin AS, Silbermann F, Porée E, Viau A, Mahaut C, Billot K, Birgy É, Garfa-Traore M, Roy S, Ceccarelli S, Mehraz M, Rodriguez PC, Deleglise B, Furio L, Jabot-Hanin F, Cagnard N, Del Nery E, Fila M, Sin-Monnot S, Antignac C, Lyonnet S, Krug P, Salomon R, Annereau JP, Benmerah A, Delous M, Briseño-Roa L, Saunier S. Agonists of prostaglandin E2 receptors as potential first in class treatment for nephronophthisis and related ciliopathies.
Proc Natl Acad Sci USA :
e
PMID:
This post is fixed term for a period of 24 months in the first instance.
Please note that if you are successful to this role, you will require medical clearance before you can commence in the role.
As part of our commitment to career development for research colleagues, the University has developed 3 levels of research role profiles.
These profiles set out firstly the generic competences and responsibilities expected of role holders at each level and secondly the general qualifications and experiences needed for entry at a particular level.
Key AccountabilitiesAlthough working under the general guidance of an academic or Principal Investigator, the postholder will contribute ideas, including enhancements to the technical or methodological aspects of their studies, thus providing substantial 'added value'
Develop and carry out the specified project using appropriate techniques and equipment as outlined in the personal requirements
Determine appropriate methodologies for research, with advice and support where required
Begin to write, with appropriate support, proposals for individual research funding or, where funders do not permit this, contribute to the writing of collective bids
Assess research findings for the need/scope for further investigations
Contribute to the writing up of their research for publication and dissemination, either through seminar and conference presentations or through publications
Present research findings, either at conferences or through publications in reputable outlets appropriate to the discipline
May be involved in the supervision, with guidance, of final year undergraduate research projects and in providing support to postgraduate research students or Research Assistants
Will need to work with the support staff and, on occasions, with undergraduate and postgraduate students, and interact intellectually with other academic members of the Institute.
May contribute to events celebrating the public engagement of science/social sciences/humanitiesDevelop an awareness of University structures, policies and procedures and relevant issues
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