Senior Scientist

2 weeks ago

London, Greater London, United Kingdom BioTalent Ltd Full time

Biotalent is supporting a leading Biotech company based in London seeking a highly motivated Antibody Engineer to join their dynamic research team. In this role, you will be the sole contributor in the design and development of antibodies. This role involves a mix of desk-based research and hands-on laboratory work, collaborating closely with other team members.

This is a great opportunity for an expert in the field that is looking for a more independent position, work closely with the CSO and have a great impact in the business.

Responsibilities:

Antibody Design and Optimisation:

  • Utilise in silico methods to design tumor-specific bispecific antibodies, antibody mutants, and novel binding moieties.
  • Conduct experiments to evaluate binding affinity, altered functionality, and stability of engineered antibodies (ELISA, Octet, FACS, etc.).
  • Focus on creating stable antibodies suitable for therapeutic applications.

Assay Development and Analysis:

  • Apply expertise in antibody engineering technologies and assays to produce, test, and analyse engineered antibodies.
  • Optimise developability properties, including half-life modulation and effector function enhancement/reduction.
  • Evaluate immunogenicity and humanness using computational tools.

Communication and Collaboration:

  • Communicate effectively within the team and across disciplines.

Requirements:

  • A PhD in Immunology, Structural Biology, Biochemistry, Protein Engineering, Molecular Biology, or related field.
  • Strong background in bispecific antibody generation or other non-conventional antibody-based moieties.
  • Familiarity with in silico antibody engineering methods (sequence analysis, molecular modelling, dynamics, machine learning-based approaches preferred)
  • Ability to apply solutions and think out of the box.
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