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Higher Scientific Officer, Biology, Centre for Target Validation
3 months ago
External Advertising End Date Advertising End Date:
- Higher Scientific Officer, Biology, Centre for Target Validation
Salary: Commencement on the salary range is subject to comparable skills and experience. Future progression is based on annual performance review.
This role is eligible for ICR Sponsorship. Support will be provided for costs associated with Visa application. If you are considering relocating to the UK, further information can be found here .
Duration of Contract: Fixed Term for 2 years (in first instance)
Hours per week: 35 hours per week (Full Time)
We are seeking to appoint a Higher Scientific Officer within the Centre for Target Validation to carry out lab-based cell biology research focused on potential therapeutic targets in cancer. Projects will involve the use of genetic techniques (RNAi/CRISPR), targeted protein degradation, tool compounds and molecular biology to generate key decision-making data in target validation and enable target prioritisation for drug discovery. The post holder will also contribute to assay development and biomarker discovery for targets that move to a drug discovery phase within the ICR’s Centre for Cancer Drug Discovery.
Key Requirements
The successful candidate must have at least a Masters level qualification in Cell Biology or an aligned subject, a knowledge of cancer biology and a knowledge of experimental approaches to therapeutic target validation in cancer. The candidate must also have the essential skills and experience needed to carry out lab-based biology research for cancer target validation:
- Skills in cell biology techniques used for target validation
- Expertise in a range of biology readouts used for screening and biomarker detection
- High motivation and a strong desire to achieve scientific excellence, prioritising quality and reproducibility of results
- Experience working in lab-based cell biology (can include PhD)
Department/Directorate Information
The ICR has established a Centre for Target Validation that will accelerate the translation of ICR and collaborator research into drug discovery programmes. The Centre will deliver bespoke, hypothesis-driven data packages to support decision-making for launch of drug discovery projects. The Centre’s dedicated resources, including biology, functional genomics, assay sciences, chemistry, and bioinformatics teams, will support joint project teams that combine the deep biological and therapeutic knowledge of ICR investigators with the validation and technical expertise of drug discovery scientists. Scientists in the Centre for Target Validation will work closely with colleagues in the ICR’s Centre for Protein Degradation to exploit emerging technology and protein degradation tools for robust target validation experiments. The Centre for Target Validation will serve as a hub, connecting researchers to expertise and resources that will validate and streamline robust, targets into drug discovery programmes in the ICR’s Centre for Cancer Drug Discovery or into collaborative programmes with external commercial therapy discovery partners.
We encourage all applicants to access the job pack attached for more detailed information regarding this role. For an informal discussion regarding the role, please contact Michael Bright via Email on [email protected] .
About The Institute of Cancer ResearchWhy work for us?
As a member of staff, you'll have exclusive access to a range of staff benefits .
The ICR is committed to supporting overseas applicants applying for roles, please click here to find out further information.
The Institute of Cancer Research, London, is one of the world's most influential cancer research institutes, with an outstanding record of achievement dating back more than 100 years. Further information about working at the ICR can be found here .
We are committed to attracting and developing the best minds in the world to join us as research team leaders in our mission – to make the discoveries that defeat cancer. Our team leaders work among brilliant and motivated people from around the world, in a vibrant research/clinical environment that values and encourages collaboration and team science.
We look forward to receiving applications from all candidates, wherever in the world they are currently based. We will select those who display the potential to become, or to support, the world leading cancer researchers of the future based on their application and performance at interview. However, we particularly welcome British applicants from black and ethnic minority backgrounds, as they are under-represented within the ICR and nationwide in STEM roles.
About The Institute of Cancer ResearchWhy work for us?
As a member of staff, you'll have exclusive access to a range of staff benefits .
The ICR is committed to supporting overseas applicants applying for roles, please click here to find out further information.
The Institute of Cancer Research, London, is one of the world's most influential cancer research institutes, with an outstanding record of achievement dating back more than 100 years. Further information about working at the ICR can be found here .
We look forward to receiving applications from all candidates, wherever in the world they are currently based. We will select those who display the potential to become, or to support, the world leading cancer researchers of the future based on their application and performance at interview. However, we particularly welcome British applicants from black and ethnic minority backgrounds, as they are under-represented within the ICR and nationwide in STEM roles.
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