Research Associate
6 days ago
About the role
Promoting the regression of angiogenesis in the pathology of rheumatoid arthritis
Low oxygen (hypoxia) is a feature of arthritic joints, which leads to the growth of blood vessels (angiogenesis) into the joint cavity.
Angiogenesis, the process of new blood cell formation, is associated with the progression of rheumatoid arthritis (RA) through aiding the recruitment of immune cells, which enhances inflammation within the joint and supports the hyperplastic proliferation of the synovium and infiltrated inflammatory immune cells.
Most current RA therapies target the inflammatory response, and although these are effective, there are some patients who do not respond to these types of treatments.
Therefore, as inflammation and angiogenesis exist concomitantly, there is an urgent need to target angiogenesis in RA for therapeutic benefit.
This is an exciting opportunity to identify signalling pathways that regulate angiogenesis, in research groups led by Dr MacKenzie, Dr Bowler, Dr Tansley, and Prof Lindsay.
In this role, you will play a key role in establishing a vascularization cell culture model to study the effects of varying oxygen levels on angiogenesis in the context of an arthritic joint.
You will then utilise your cell culture, western blot and immunohistochemically expertise to elucidate the signalling pathways triggered by oxygen changes.
As a member of Research Staff at the University of Bath, you will be encouraged to take up a minimum of 10 days professional development pro rata per year"
We are seeking a talented postdoctoral research associate to join our team and contribute to a cutting-edge project investigating the role of oxygen in cellular signalling pathways in the context of rheumatoid arthritis & the regulation of angiogenesis.
This position would suit a candidate who has just completed their PhD in a relevant subject.
This is fixed-term research grant funded by the Bath Institute for Rheumatic Disease.
This is a part-time role.
About the Role (Key Responsibilities):
- Investigate the impact of varying oxygen levels on angiogenic processes: Utilize your expertise in cell culture and related techniques to design & conduct experiments that explore how oxygen availability influences the formation of new blood vessels.
- Elucidate signalling pathways triggered by oxygen changes: Use western blot analysis and ELISA to identify and characterize the key signalling molecules activated by different oxygen levels.
- Global secretome analysis: Use mass spectrometry analysis (MC2 facility) and RNAseq for quantitative analysis of responses to change in oxygen.
- Data analysis and dissemination: Analyse and interpret experimental data to draw meaningful conclusions and contribute to the advancement of the research field.
- Prepare high-quality research reports and manuscripts for publication, and participate in the development of grant proposals & presentations at conferences.
What we can offer you:
- a very generous employer contributory pension scheme
- generous annual leave allowance with an additional 5 discretionary days so that you can enjoy a positive work life balance
- we are a family-friendly University and with an increasingly agile workforce, are open to flexible working arrangements
- an excellent reward package that recognises the talents of our diverse workforce
- a wide range of personal & professional development opportunities
- a number of support options available for new & existing staff to help with the cost of some immigration expenses which you may be eligible for: Relocation allowance, Visa Reimbursement, Interest-Free Loan.
Find out more about our benefits.
We consider ourselves to be a university where difference is celebrated, respected and encouraged.
£37,099 to £44,263. Grade 7, per annum
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