PLRS – Pharmacology Expert

4 weeks ago

London, United Kingdom The Francis Crick Institute Full time

Location: The Francis Crick Institute, Midland Road, London

Short summary

We are seeking a creative and driven pharmacology expert, with deep expertise in a range of in vitro assays technologies and their application in early drug discovery projects. The position is embedded within the Chemical Biology and HTS STPs and will draw on the expertise and capability to be found in both groups. The successful candidate will establish state of the art screening approaches for the identification and optimisation of chemical modulators of protein targets, along with strategies for linking their mechanism of action to treatment of disease. This role presents the opportunity to profoundly influence translational science at the Crick, both in lab-based contributions as pharmacology/assay lead on early drug discovery teams and in the provision of pharmacology and drug discovery consultancy on nascent translational projects.

Key Responsibilities

  • Work closely with STP leadership (including Chemical Biology, HTS, Structural Biology, Proteomics, NMR) to establish state-of-the-art cross-STP screening approaches for hit identification, validation and optimisation against novel targets; establish suitable assay technologies than enable the selection of potential probes and therapeutics.
  • Apply these approaches in Crick translational projects, advising on screening strategy for new targets and supporting the development of relevant assays for compound screening.
  • Where appropriate, build relationships with CROs to expand access to novel assay capabilities.
  • Contribute to interdisciplinary drug discovery teams as pharmacology/assay lead, taking accountability for the development of complex biological assays and the elucidation of mechanism of action.
  • Where appropriate, take an overall project leadership of drug discovery activities in these teams.
  • Demonstrate scientific leadership through acting as assay area expert; stay abreast of the latest literature and developments in the field; propose and drive technology projects that optimise/modernise the current drug discovery process

About us

The Francis Crick Institute is a biomedical discovery institute dedicated to understanding the fundamental biology underlying health and disease. Its work is helping to understand why disease develops and to translate discoveries into new ways to prevent, diagnose and treat illnesses such as cancer, heart disease, stroke, infections, and neurodegenerative diseases.

An independent organisation, its founding partners are the Medical Research Council (MRC), Cancer Research UK, Wellcome, UCL (University College London), Imperial College London and King’s College London.

The Crick was formed in 2015, and in 2016 it moved into a new state-of-the-art building in central London which brings together 1500 scientists and support staff working collaboratively across disciplines, making it the biggest biomedical research facility under in one building in Europe.

The Francis Crick Institute will be world-class with a strong national role. Its distinctive vision for excellence includes commitments to collaboration; developing emerging talent and exporting it the rest of the UK; public engagement; and helping turn discoveries into treatments as quickly as possible to improve lives and strengthen the economy.

  • If you are interested in applying for this role, please apply via the ‘Apply’ button above.
  • All offers of employment are subject to successful security screening and continuous eligibility to work in the United Kingdom.

From £50,000 with benefits, depending on skills and experience

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