Postdoctoral Fellow

7 days ago

Central London, United Kingdom The Francis Crick Institute Full time €43,210

Postdoctoral Fellow – Z Cader Lab Reporting to: Dr Zaeem Cader, Clinician Scientist Group Leader
This is a full-time, fixed term (4 year) position on Crick terms and conditions of employment.
The Cader lab studies the complex interplay between metabolism and immunity across every level of organismal organisation from proteins to cells to organs and the whole-body. The Cader lab will be starting at the Crick in December 2024.

The Project
We are seeking an enthusiastic, hard-working and conscientious Postdoctoral Fellow to join our new research team at the Francis Crick Institute. This project will follow-up and further investigate this intriguing interplay between metabolism, redox, energy homeostasis and immunity. In particular, the prospective candidate(s) would drive either of the following projects:
Our work has highlighted that these are crucial for supporting the energetic and chemical demands of immune signalling, which must respond rapidly but flexibly to changing levels of intracellular pathogenic threat. We look to employ advanced imaging and metabolomic approaches such as super-resolution microscopy, imaging cytometry, redox proteomics, and stable-isotope flux analysis to investigate these processes in unprecedented detail with an aim to discover entirely novel immunometabolic biology.
Metabolic dysfunction underpins virtually every ‘disease of westernisation’ from diabetes to dementia. In this project, we seek to investigate cellular metabolism in vivo and study metabolic cross-talk in physiological and disease relevant states in animal models. We are particularly interested in developing approaches for intravital imaging and/or in vivo stable isotope flux analysis. Both post-doctoral projects will harness genetic and chemical tools to manipulate and image key metabolic and redox pathways. Candidates will also be encouraged and supported to innovate new tools and methods for studying immunometabolism both in vivo and in cells through genetic engineering and chemical biology approaches. This will be combined with next-generation genome editing screens to discover entirely novel biology and new mechanisms linking metabolism and redox to immune function. Importantly, the proposed work will generate important insight into the nascent fields of immunometabolism to pave the way for better disease understanding and therapeutic strategies.
Postdoctoral Fellows will lead their own projects, contribute to other projects on a collaborative basis (both in the lab and with external collaborators) and may guide PhD students in their research. PhD in a relevant life science field or in the final stages of PhD submission
Extensive wet-lab experience with expertise across several relevant methods in cell biology, molecular biology, immunology or metabolism.
Technical expertise in one or more of the following: imaging, metabolomics or animal models 
Experience of working independently, designing experiments and introducing new techniques into a lab
Track record of writing papers as evidenced by publications or submitted manuscripts in referred journals
Some experience performing molecular cloning, genetic modification and/or genome editing
In vivo projects would require significant experience with animal experimentation
Shows attention to detail with a clear focus on high quality data and documentation
At the Crick, we conduct research at the forefront of biomedical research. We combine rigour with an open and collaborative culture, and are outward-looking, reflecting our status as a partnership of six organisations aiming to pool knowledge, ideas and resources.
We have a wide research portfolio with no divisions or departments, bringing biomedical researchers together with clinicians, physical scientists and applied scientists from our pharmaceutical partners.
Our science technology platforms provide our researchers with access to state-of-the-art technology and expertise.
We provide an excellent learning environment with dedicated education programmes in public engagement with science, education and personal development, and a postdoc training programme that prepares scientists for leadership roles in science.
If you are interested in applying for this role, please apply via our website . All offers of employment are subject to successful security screening and continuous eligibility to work in the United Kingdom.
If you require a visa to work in the UK we will help support your application should you be successful
For more information on our great pay and benefits package please click here:
Equality, Diversity & Inclusion:
We are committed to providing equal employment opportunities, regardless of ethnicity, nationality, gender, sexual orientation, gender identity, religion, pregnancy, age, disability, or civil partnership, marital or family status. Diversity is essential to excellence in scientific endeavour. We want the Crick to be a place where everyone feels valued and where diversity is celebrated and seen as part of the foundation for our Institute’s success.
The Crick is committed to creating equality of opportunity and promoting diversity and inclusivity. We all share in the responsibility to actively promote dignity, respect, inclusivity and equal treatment and it is our aim to ensure that these principles are reflected and implemented in all strategies, policies and practices.
Read more on our website: 

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