Senior Research Scientist

Department Oncology Research
Key Responsibilities The incumbent is expected to have strong working knowledge deriving deep mechanistic immuno-biology insight into our therapeutic platforms and disease indications of strategic interest and play a pivotal role in generating pharmacology data on new drug formats/platforms, dissecting drug MOA and immunophenotyping response and resistance mechanisms. To establish combination screening workflows designed to explore the pharmacology of agents, including standard-of-care anti-cancer drugs, on target/disease biology and immune cell activation and redirected killing.
Pharmacology: Lead projects and collaborate with colleagues to build pharmacology data on new drug formats (e.g. Explore the effect of these agents (including standard-of care therapeutics) on target/disease biology and drug efficacy/MOA. Ensure data packages support clinical line-of-sight. Generate patient stratified in vitro models of disease that accurately model drug target biology and complex disease TMEs. Utilise in pharmacology screens.
Proactively contribute to internal project / programme team meetings. Generate and communicate knowledge and data packages to solve complex problems and help inform go / no-go decisions
Establish and support collaborations with both internal and external partners/ key opinion leaders to accelerate oncology research and pharmacological studies
Keep up to date with scientific literature and the latest developments in applicable research fields
Provide technical training and mentorship to support and empower team members
Strong working knowledge and understanding of immunology and cancer cell biology
Significant prior pharmacology experience, testing the effects of therapeutic molecules and combinations on tumour biology, immune cell activation and cancer cell killing
Capable in the genetic modification of cancer and/or primary human immune cells (e.g., Strong molecular biology and biochemistry skills (DNA cloning, mutagenesis, western blotting, protein purification).
3D in vitro modelling experience (e.g., R, Python)
In vivo pharmacology experience
PhD or equivalent in Immunology, Immuno-oncology, Pharmacology, Oncology, Molecular Cell Biology, Biochemistry, or similar discipline
3+ years’ experience of post-doctoral research in an academic or industrial setting
Or, MSc degree or BSc degree with role-specific equivalent research or industrial experience.
IMCR) is a pioneering, commercial-stage T cell receptor biotechnology company whose purpose is to develop and commercialize a new generation of transformative medicines which address unmet patient needs in oncology, infectious diseases and autoimmune disease. Our leaders in R&D are internationally recognised as some of the biotech industry’s most successful drug developers. We are creating not just an environment where great minds can interact but an innovation powerhouse answering the big questions.
Focused on delivering first-in-class biological therapies to patients, we have developed a highly innovative soluble TCR platform. Our ImmTAX molecules underpin a new generation of precision engineered drugs that harness the immune system to treat a broad spectrum of diseases with high unmet medical need, including oncology, infectious diseases and autoimmune diseases.
At Immunocore, we recognize that our employees are our greatest asset. By embracing Science, Trust, Respect, Integrity, Diversity, and Entrepreneurship (STRIDE), we create an environment where collaboration thrives, ideas flourish, and transformative changes happen. We are dedicated to developing breakthrough therapies that transform patients’ lives, advancing medicine, and supporting one another in these pursuits.
As such, we are committed to fostering an inclusive workplace where everyone feels valued, respected, and empowered. We encourage applications from individuals of all backgrounds, regardless of race, color, religion, sex, sexual orientation, gender identity or expression, pregnancy, age, national origin, disability status, or any other characteristic protected by law.