Program Lead

4 days ago

Little Chesterford Essex, United Kingdom Mestag Therapeutics Full time

Program Lead – (Phase I) Immune-oncology Chesterford Research Park – Cambridge
Permanent
Competitive salary and extensive benefits package


We believe in a culture of diversity, equality and investing in people to ensure our talented and passionate team members can fulfil their full potential.

We are now transitioning our lead programme into clinic - There has never been a better time t o join #TeamMestag

The Program Lead will be responsible for the leadership of our M300 clinical program. This is a senior opening but also requires a hands-on approach , bridging clinical operations, CMC, translational and development program management, ensuring seamless execution across functions and external partners in readiness for future Phase II/III development.

Partnering with the program’s project manager, with internal and external experts in research, Translational Science & bioanalytical, CMC, Clinical, Clinical Operations, Biostatistics, PK and Regulatory, to ensure the timely execution of the program strategy and operational plans
Partner with the CMO & regulatory teams to lead clinical protocol development and amendments including first-in-human, safety, PK/PD, DLT, and biomarker-driven expansion plans.
Collaborating with the program’s project manager to track and own program timelines, budgets, and deliverables.
Develop and maintain risk mitigations strategies
Serve as subject matter expert for the investigational therapeutic, integrating preclinical, biomarker, and PK/PD data into patient safety and efficacy assessments.
Provide input to regulatory and clinical documents, and key publications.
Together with the CMO and clinical operations team, engage with investigators, clinical sites, and key opinion leaders in immuno-oncology to build relationships and to enable smooth progress of the clinical trial and planning for future development
Drive and support interactions with regulatory agencies and development partners


Advanced scientific or medical degree (MD, PhD, PharmD preferred) in oncology, immunology, or related field. Extensive experience in oncology drug development, with previous experience of leading early-phase (Phase 1/1b) programs.
Demonstrated leadership in immune-oncology projects (e.g., We work flexibly with a strong team spirit and offer a highly competitive total rewards package including competitive salaries, pension contributions, private medical insurance, income protection and more.


We have access to a range of onsite facilities including a gym, canteen, golf course and free
onsite parking.

We value the relationships of our close-knit team and strive to make meaningful connections in our community. We frequently hold Town Halls and team lunches, and have an active social committee, organizing regular events and ‘giving back’ activities supporting charities close to our hearts.


We are based in spacious and modern laboratory and office facilities at Chesterford Research Park near Cambridge, UK – right in the very heart of the UK life science sector. Our facilities are kitted out with state-of-the-art instruments to enable our dedicated researchers to deliver incredible science.

Our founding investigators comprise global experts in inflammatory disease, cancer, computational biology and fibroblast biology from the University of Oxford, Brigham & Women’s Hospital, Harvard Medical School and Cold Spring Harbor Laboratory. For further informatio n please visit our website

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