Head of Implementation

2 weeks ago

Cambridge Cambridgeshire, United Kingdom CK Group Full time

We have an exceptional opportunity for an experienced computational chemist and drug hunter to lead the Computational Chemistry team at Nxera Pharma (formerly Sosei Heptares).
This is an exciting position, leveraging the NxWave platform to lead application of computational approaches in drug discovery projects and develop novel, computational methodology, for wider utility.

In addition to several products being commercialized in Japan, they are advancing an extensive pipeline of over 30 active programs from discovery through to late clinical stage internally and in partnership with leading pharma and biotech companies including Lilly, GSK, AbbVie, Verily, Neurocrine, Takeda, Genentech/Roche, Pfizer, Boehringer Ingelheim, Medicxi, Aditum Bio.
This pipeline is focused on addressing major unmet needs in some of the fastest-growing areas of medicine across CNS, GI and immunology, metabolic disorders and rare diseases, and leverages the power of their unique and industry leading GPCR-targeted structure-based drug discovery “NxWave” platform to provide a sustainable source of best- or first-in-class candidates.

The successful applicant will manage a team of computational chemists supporting a diverse portfolio of internal and partnered projects. Ensure scientific excellence of the computational chemistry team through effective line-management and mentoring, supporting delivery of key internal and partnered milestones.
Work with key stakeholders across other disciplines in Nxera Pharma to influence R&D strategy and define and execute high quality computational strategies that enhance delivery of projects across the portfolio.
Drive continuous growth and development of cutting-edge SBDD & CADD methodologies.
Lead implementation of innovative computational solutions (e.g. Support growth of our NxStaR Platform Technology by implementation of machine learning and AI approaches for in silico protein design.

As Head of Computational Chemistry you will require:

Evidence of broad expertise in computational sciences with an emphasis on structure-based drug design (including GPCRs), ligand- and structure-based virtual screening, cheminformatics, and machine learning.
Track record of identifying, developing, and applying innovative solutions to scientific and technological problems faced in computational molecular design and in the wider drug discovery organisation.
Extensive knowledge of related disciplines (e.g. chemistry, biology, DMPK, safety) with demonstrable evidence of developing and implementing new scientific strategies in collaboration.
Proficiency in membrane protein structural modelling using the latest AI implementations.
Evidence of influencing project and organisational scientific strategy.
Competitive salary and benefits package.

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