Bioinformatics Data Scientist
3 days ago
The Company Sitryx Therapeutics is a drug discovery company focused on harnessing immuno-metabolism to develop new therapies to treat auto-immunity and inflammation. We are building a broad pipeline of first- and best-in-class therapies by identifying novel targeted approaches based on how changes in metabolism modulate immune cell function.
We are looking for a fresh PhD graduate, or someone with an undergraduate/masters degree with some industry experience to work with our Bioinformatics lead to develop our bioinformatics capability. This role will help uncover novel therapeutic targets and pathways, contributing to innovative treatments in immuno-metabolism. This is a 12-18 month fixed-term contract.
Leading the development and growth of the in-house omics database
Ensuring omics data is processed using well established and up-to-date methods to generate high quality, analysis-ready data.
Developing and implementing sophisticated analysis methods, including meta-analysis and Machine Learning (ML) to interrogate the different omics datasets across different immune-related disorders to identify novel therapeutic targets and pathways.
Develop visualisation tools and dashboards using RShiny to allow team members easy access to the data
Experience in processing and analysing transcriptomics data, including performing quality control checks, exploring technical and biological artifacts, correcting for batch effects (COMBAT and SVA), PCA analysis, gene quantification, gene annotation, differential expression analysis (limma and Deseq2) and pathway analysis.
Experience in acquiring and processing publicly available omics data from repositories such as GEO, ArrayExpress and SRA
Experience in developing bioinformatics pipelines
Familiarity with Linux OS and cloud computing
PhD in immunology, metabolism, cellular or computational science, or a higher degree with several years of working as a data scientist in the pharmaceutical industry.
Knowledge and experience in apply ML to omics data for drug discovery
Multi-omics experience and integrative analysis of different omics datasets
Knowledge of relevant areas of biology such as metabolism, immunology and cancer biology.
a competitive salary, commensurate with qualifications and experience, and a comprehensive benefits package including pension and health insurance.
remote working opportunities.
Sitryx is committed to building a diverse workforce and recognises that diverse and inclusive teams build a strong and innovative culture.
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