Technical Management Specialist

Do you want to help us improve human health and understand life on Earth? Make your mark by shaping the future to enable or deliver life-changing science to solve some of humanity’s greatest challenges. We are seeking a motivated Technical Specialist to join an excellent interdisciplinary team exploring how the immune system responds to and shapes neurodegenerative diseases, including Alzheimer’s Disease, Parkinson’s Disease, and Amyotrophic Lateral Sclerosis (ALS ) . Validate genetic modulators of immune responses using biochemical assays and high-content imaging, in collaboration with partner teams
Collaborate with Dr Bayraktar’s group and computational teams led by Drs Strauss, Lotfollahi and Prof Saez-Rodriguez to integrate data you would generate with patient data to prioritise perturbation targets and disease pathways
Contribute to a unique, cross-comparative analysis integrating cellular models and patient-derived data to uncover mechanisms of immune dysregulation in neurodegeneration

Open Targets (OT) aims to systematically identify and prioritize drug targets by combining genetic, clinical, and functional genomics data. the European Bioinformatics Institute (EMBL-EBI), a global leader in the management, integration, and analysis of public domain life science data; and world-leading pharmaceutical companies such as GSK, Sanofi, MSD, Pfizer, and Genentech.

As part of the Open Targets team at the Wellcome Sanger Institute, you’ll join a world-class research environment with access to cutting-edge facilities and mentoring from leading experts across academia and industry. This position offers an exciting opportunity to contribute to a large-scale, collaborative project at the intersection of genetics, immunology, and neuroscience applying advanced technologies such as CRISPR, iPSC models, single-cell transcriptomics and large-scale phenotypic screening to drive discovery and therapeutic innovation.
Apply now to join a dynamic team advancing our understanding of how immune mechanisms influence neurodegenerative disease and to help shape the next generation of therapeutic discovery.

Degree, MSc, or equivalent experience in a relevant subject area e.g. Cell Biology, Neuroscience, Immunology, Molecular Biology or a closely related field
In-depth knowledge of genome engineering and pooled CRISPR screening
Flexible working hours (occasional weekend work required)
Proven track record in delivering complex experimental scientific projects.
Contract Length: 18 months
Closing Date: 11th January 2026
Interviews are scheduled to take place 27th-29th January 2026.

We recognise that there are many benefits to Hybrid Working; including an improved work-life balance, with more focused time, as well as the ability to organise working time so that collaborative opportunities and team discussions are facilitated on campus. The hybrid working arrangement will vary for different roles and teams. The nature of your role and the type of work you do will determine if a hybrid working arrangement is possible.

Equality, Diversity And Inclusion
We aim to attract, recruit, retain and develop talent from the widest possible talent pool, thereby gaining insight and access to different markets to generate a greater impact on the world. We have a supportive culture with the following staff networks, LGBTQ+, Parents and Carers, Disability and Race Equity to bring people together to share experiences, offer specific support and development opportunities and raise awareness. The networks are also a place for allies to provide support to others.
We are proud to deliver an awarding campus-wide employee wellbeing strategy and programme. The Technician Commitment aims to empower and ensure visibility, recognition, career development and sustainability for technicians working in higher education and research, across all disciplines.