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Research Scientist
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Research Scientist
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Research Scientist
2 months ago
Postdoctoral Research Scientist – (24P-46) The Pirbright Institute
Fixed-Term Contract – 30 months from start date – (not to exceed 27/05/2027)
The Pirbright Institute delivers world-leading research to understand, predict, detect, and respond to viral disease outbreaks. We study viruses of livestock that are endemic and exotic to the UK, including zoonotic viruses, by using the most advanced tools and technologies to understand host-pathogen interactions in animals and arthropod vectors. Our Institute is made up of a dynamic and vibrant community of staff covering a diverse set of chosen fields, backgrounds, and experience. We all play a crucial role in furthering the Institute’s aspirations, advancing the frontiers of science and knowledge through our excellent scientific research, knowledge sharing and contribution; We will produce viral-vectored vaccines expressing NP+M1 with NA and test the protective efficacy of different routes of immunisation in influenza-exposed pigs, to mimic the effect of human pre-exposure to influenza virus. We will study T and B cell responses in detail in different tissues to determine the effect of route of vaccination and attempt to identify correlates of protection. Pigs are genetically, immunologically, physiologically, and anatomically more like humans than small animals and an excellent model for human influenza. The project will require a scientist with training in a wide range of immunological and virological techniques such as FACS analysis, ELISA, ELISPOT, microneutralisation, virus propagation and plaque assays.
This project represents an exciting opportunity to be part of a consortium comprising the Pandemic Sciences Institute, University of Oxford, the Francis Crick Institute, and the Pirbright Institutes carrying out One Health research. It is suitable for virologists and/or immunologists with a keen interest in translational research for human and animal health. Time management, reliability under pressure, decision making/problem solving skills, action-oriented, entrepreneurial, agile, ethical/credible, inspiring, creative, influential, collaborative, emotionally intelligent, diplomatic, results driven, passionate, engaging and recognising.
Responsible for conducting research into transmission, evolution, and immunity to swine influenza viruses.
Analysis of B and T cell responses after influenza infection and/or immunisation (T and B cell ELISPOT, Flow cytometry, cell proliferation).
Analysis of the evolution and transmission of influenza viruses.
Contribute to animal studies to evaluate properties of transmission blockers.
Responsible for working as part of a research team, which will include.
Communicating progress and data, including presentations at internal and external meetings.
Helping supervise undergraduate, MSc, PhD students and staff.
Contributing to grant proposal development and writing to support the group’s mission.
Developing and maintaining documentation associated with the health, safety, and biosecurity of the research to preserve a safe working environment.
Assist with lab management (ordering, looking after equipment, sample inventories)
Perform outreach duties.
A PhD or equivalent in a relevant branch of biosciences.
A willingness to work outside normal working hours and to undertake travel worldwide.
Experience in immunology including flow cytometry, analysis of cellular and humoral responses, ELISPOT, proliferation assays, ELISA, cell sorting.
Evidence of building collaborative relationships.
Experience of flow cytometry and other immunological or molecular biology techniques.
Experience of working in a laboratory environment.
Evidence of networking skills with the ability to build effective collaborative relationships.
Computer literate, good knowledge of computer programs and experience in data presentation.
Generous Group Personal Pension Scheme and life cover (subject to age and earnings).
~25 days annual leave per annum, pro rata, plus 10.Buy and sell annual leave.
~ Option to carry over up to two weeks annual leave.
~ Pirbright gym with subsidised membership.
~ Pirbright Lifestyle Hub (employee discount site).
~ Cycle to work.
~ Childcare allowance.
~ Free onsite parking.
~ Electric car charging facilities.