Research and Development Technologist

2 days ago

Cambridge Cambridgeshire, United Kingdom LanceSoft UK Full time

Job Title: Technologist - Research & Development

Location: Cambridge, UK

Duration: 12 months+ extensions

Job Description:

  • Successful candidate's first day will be at the Slough site for induction, then to join the HM/team in Cambridge from day 2 onwards.
  • **At least 1 year lab experience in an academic and/or industrial setting required.**

Top 3 must have skills

  • Cell Culture (CHO desirable)
  • molecular biology - PCRs, sangers, NGS etc
  • Gene editing tools (CRISPR)

Key responsibilities:

  • Contribute to the delivery of new mammalian expression hosts and vector systems for the expression of complex therapeutic proteins.
  • Engineer mammalian cell lines (e.g. random integration, targeted integration, and gene editing – e.g. CRISPR-based systems).
  • Generate mammalian expression vectors using state-of-the-art assembly techniques.
  • Phenotypic characterization of edited cell lines with relevant assays (e.g. NGS, ddPCR, qPCR, and flow cytometry) and cell culture techniques (e.g., shake flask/ bioreactor).
  • Work closely with other groups within R&D to deliver solutions or improvements in recombinant protein. IN particular with R&D Process Development, Microbial Expression & Protein Analytics)
  • Actively keep abreast of relevant academic literature (e.g., cell engineering and expression technologies).

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